المؤلفون: Mileva, N., Nagumo, S., Mizukami, T., Sonck, J., Berry, C., Gallinoro, E., Monizzi, G., Candreva, A., Munhoz, D., Vassilev, D., Penicka, M., Barbato, E., De Bruyne, B., Collet, C.

المصدر: Journal of the American Heart Association, vol. 11, no. 7, pp. e023207

مصطلحات موضوعية: Coronary Angiography, Coronary Artery Disease/diagnostic imaging, Coronary Artery Disease/epidemiology, Coronary Vasospasm/diagnostic imaging, Coronary Vasospasm/epidemiology, Coronary Vessels/diagnostic imaging, Female, Humans, Male, Microcirculation, Microvascular Angina, Prevalence, angina with nonobstructive coronary artery disease, ischemia with no obstructive coronary artery disease, vasospastic angina

الوصف: Background A relevant proportion of patients with suspected coronary artery disease undergo invasive coronary angiography showing normal or nonobstructive coronary arteries. However, the prevalence of coronary microvascular disease (CMD) and coronary spasm in patients with nonobstructive coronary artery disease remains to be determined. The objective of this study was to determine the prevalence of coronary CMD and coronary vasospastic angina in patients with no obstructive coronary artery disease. Methods and Results A systematic review and meta-analysis of studies assessing the prevalence of CMD and vasospastic angina in patients with no obstructive coronary artery disease was performed. Random-effects models were used to determine the prevalence of these 2 disease entities. Fifty-six studies comprising 14 427 patients were included. The pooled prevalence of CMD was 0.41 (95% CI, 0.36-0.47), epicardial vasospasm 0.40 (95% CI, 0.34-0.46) and microvascular spasm 24% (95% CI, 0.21-0.28). The prevalence of combined CMD and vasospastic angina was 0.23 (95% CI, 0.17-0.31). Female patients had a higher risk of presenting with CMD compared with male patients (risk ratio, 1.45 [95% CI, 1.11-1.90]). CMD prevalence was similar when assessed using noninvasive or invasive diagnostic methods. Conclusions In patients with no obstructive coronary artery disease, approximately half of the cases were reported to have CMD and/or coronary spasm. CMD was more prevalent among female patients. Greater awareness among physicians of ischemia with no obstructive coronary arteries is urgently needed for accurate diagnosis and patient-tailored management.

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35301851; info:eu-repo/semantics/altIdentifier/eissn/2047-9980; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_50E3B2AAE3E00; https://serval.unil.ch/notice/serval:BIB_50E3B2AAE3E0Test; urn:issn:2047-9980; https://serval.unil.ch/resource/serval:BIB_50E3B2AAE3E0.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_50E3B2AAE3E00Test

الإتاحة: https://doi.org/10.1161/JAHA.121.023207Test
https://serval.unil.ch/notice/serval:BIB_50E3B2AAE3E0Test
https://serval.unil.ch/resource/serval:BIB_50E3B2AAE3E0.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_50E3B2AAE3E00Test

المؤلفون: Gallinoro, E., Bertolone, D.T., Mizukami, T., Paolisso, P., Bermpeis, K., Munhoz, D., Sakai, K., Seki, R., Ohashi, H., Esposito, G., Caglioni, S., Mileva, N., Leone, A., Candreva, A., Belmonte, M., Storozhenko, T., Viscusi, M.M., Vanderheyden, M., Wyffels, E., Bartunek, J., Sonck, J., Barbato, E., Collet, C., De Bruyne, B.

المصدر: JACC. Cardiovascular interventions, vol. 16, no. 22, pp. 2767-2777

مصطلحات موضوعية: Humans, Coronary Circulation, Fractional Flow Reserve, Myocardial, Thermodilution/methods, Reproducibility of Results, Treatment Outcome, Coronary Vessels, Microcirculation, CFR, FFR, angina, coronary artery disease, coronary flow, microvascular dysfunction

الوصف: Coronary flow reserve (CFR) and microvascular resistance reserve (MRR) can, in principle, be derived by any method assessing coronary flow. The aim of this study was to compare CFR and MRR as derived by continuous (CFR cont and MRR cont ) and bolus thermodilution (CFR bolus and MRR bolus ). A total of 175 patients with chest pain and nonobstructive coronary artery disease were studied. Bolus and continuous thermodilution measurements were performed in the left anterior descending coronary artery. MRR was calculated as the ratio of CFR to fractional flow reserve and corrected for changes in systemic pressure. In 102 patients, bolus and continuous thermodilution measurements were performed in duplicate to assess test-retest reliability. Mean CFR bolus was higher than CFR cont (3.47 ± 1.42 and 2.67 ± 0.81 [P < 0.001], mean difference 0.80, upper limit of agreement 3.92, lower limit of agreement -2.32). Mean MRR bolus was also higher than MRR cont (4.40 ± 1.99 and 3.22 ± 1.02 [P < 0.001], mean difference 1.2, upper limit of agreement 5.08, lower limit of agreement -2.71). The correlation between CFR and MRR values obtained using both methods was significant but weak (CFR, r = 0.28 [95% CI: 0.14-0.41]; MRR, r = 0.26 [95% CI: 0.16-0.39]; P < 0.001 for both). The precision of both CFR and MRR was higher when assessed using continuous thermodilution compared with bolus thermodilution (repeatability coefficients of 0.89 and 2.79 for CFR cont and CFR bolus , respectively, and 1.01 and 3.05 for MRR cont and MRR bolus , respectively). Compared with bolus thermodilution, continuous thermodilution yields lower values of CFR and MRR accompanied by an almost 3-fold reduction of the variability in the measured results.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38030361; info:eu-repo/semantics/altIdentifier/eissn/1876-7605; https://serval.unil.ch/notice/serval:BIB_681376CA1588Test; urn:issn:1936-8798

الإتاحة: https://doi.org/10.1016/j.jcin.2023.09.027Test
https://serval.unil.ch/notice/serval:BIB_681376CA1588Test

المؤلفون: Gallinoro, E., Bertolone, D.T., Fernandez-Peregrina, E., Paolisso, P., Bermpeis, K., Esposito, G., Gomez-Lopez, A., Candreva, A., Mileva, N., Belmonte, M., Mizukami, T., Fournier, S., Vanderheyden, M., Wyffels, E., Bartunek, J., Sonck, J., Barbato, E., Collet, C., De Bruyne, B.

المصدر: EuroIntervention, vol. 19, no. 2, pp. e155-e166

مصطلحات موضوعية: Humans, Coronary Circulation, Fractional Flow Reserve, Myocardial, Thermodilution, Microcirculation, Reproducibility of Results, Vascular Resistance, Cardiac Catheterization, Coronary Vessels, Coronary Angiography

الوصف: A bolus thermodilution-derived index of microcirculatory resistance (IMR) has emerged as the standard for assessing coronary microvascular dysfunction (CMD). Continuous thermodilution has recently been introduced as a tool to quantify absolute coronary flow and microvascular resistance directly. Microvascular resistance reserve (MRR) derived from continuous thermodilution has been proposed as a novel metric of microvascular function, which is independent of epicardial stenoses and myocardial mass. We aimed to assess the reproducibility of bolus and continuous thermodilution in assessing coronary microvascular function. Patients with angina and non-obstructive coronary artery disease (ANOCA) at angiography were prospectively enrolled. Bolus and continuous intracoronary thermodilution measurements were obtained in duplicate in the left anterior descending artery (LAD). Patients were randomly assigned in a 1:1 ratio to undergo either bolus thermodilution first or continuous thermodilution first. A total of 102 patients were enrolled. The mean fractional flow reserve (FFR) was 0.86±0.06. Coronary flow reserve (CFR) calculated with continuous thermodilution (CFR cont ) was significantly lower than bolus thermodilution-derived CFR (CFR bolus ; 2.63±0.65 vs 3.29±1.17; p<0.001). CFR cont showed a higher reproducibility than CFR bolus (variability: 12.7±10.4% continuous vs 31.26±24.85% bolus; p<0.001). MRR showed a higher reproducibility than IMR (variability 12.4±10.1% continuous vs 24.2±19.3% bolus; p<0.001). No correlation was found between MRR and IMR (r=0.1, 95% confidence interval: -0.09 to 0.29; p=0.305). In the assessment of coronary microvascular function, continuous thermodilution demonstrated significantly less variability on repeated measurements than bolus thermodilution.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36809253; info:eu-repo/semantics/altIdentifier/eissn/1969-6213; https://serval.unil.ch/notice/serval:BIB_744ECA946B06Test; urn:issn:1774-024X

الإتاحة: https://doi.org/10.4244/EIJ-D-22-00772Test
https://serval.unil.ch/notice/serval:BIB_744ECA946B06Test

المؤلفون: Candreva, A., Gallinoro, E., Fernandez Peregrina, E., Sonck, J., Keulards, DCJ, Van't Veer, M., Mizukami, T., Pijls, NHJ, Collet, C., De Bruyne, B.

المصدر: Catheterization and cardiovascular interventions, vol. 100, no. 2, pp. 199-206

مصطلحات موضوعية: Automation, Coronary Circulation, Coronary Vessels, Humans, Hyperemia, Microcirculation, Thermodilution/methods, Treatment Outcome, Vascular Resistance, continuous intracoronary thermodilution, coronary flow reserve, coronary physiology, microvascular function, microvascular resistance reserve

الوصف: Microvascular resistance reserve (MRR) as derived from continuous intracoronary thermodilution specifically quantifies microvasculature function. As originally described, the technique necessitates reinstrumentation of the artery and manual reprogramming of the infusion pump when performing resting and hyperemic measurements. To simplify and to render this procedure operator-independent, we developed a fully automated method. The aim of the present study is to validate the automated procedure against the originally described one. For the automated procedure, an infusion pump was preprogrammed to allow paired resting-hyperemic thermodilution assessment without interruption. To validate the accuracy of this new approach, 20 automated measurements were compared to those obtained in the same vessels with conventional paired resting-hyperemic thermodilution measurements (i.e., with a sensor pullback at each infusion rate and manual reprogramming of the infusion pump). A close correlation between the conventional and the automated measuring technique was found for resting flow (Q rest : r = 0.89, mean bias = 2.52; SD = 15.47), hyperemic flow (Q hyper : r = 0.88, mean bias = -2.65; SD = 27.96), resting microvascular resistance (R μ-rest : r = 0.90, mean bias = 52.14; SD = 228.29), hyperemic microvascular resistance R μ-hyper : r = 0.92, mean bias = 12.95; SD = 57.80), and MRR (MRR: r = 0.89, mean bias = 0.04, SD = 0.59). Procedural time was significantly shorter with the automated method (5'25″ ± 1'23″ vs. 4'36″ ± 0'33″, p = 0.013). Continuous intracoronary thermodilution-derived measurements of absolute flow, absolute resistance, and MRR can be fully automated. This further shortens and simplifies the procedure when performing paired resting-hyperemic measurements.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35723684; info:eu-repo/semantics/altIdentifier/eissn/1522-726X; https://serval.unil.ch/notice/serval:BIB_71C8B96660D6Test; urn:issn:1522-1946

الإتاحة: https://doi.org/10.1002/ccd.30244Test
https://serval.unil.ch/notice/serval:BIB_71C8B96660D6Test

المؤلفون: Fournier, S., Keulards, DCJ, van 't Veer, M., Colaiori, I., Di Gioia, G., Zimmermann, F.M., Mizukami, T., Nagumo, S., Kodeboina, M., El Farissi, M., Zelis, J.M., Sonck, J., Collet, C., Pijls, NHJ, De Bruyne, B.

المصدر: EuroIntervention, vol. 17, no. 4, pp. e309-e316

مصطلحات موضوعية: Coronary Angiography, Coronary Circulation, Coronary Vessels/diagnostic imaging, Humans, Microcirculation, Reference Values, Thermodilution, Vascular Resistance

الوصف: Absolute hyperaemic coronary blood flow (Q, in mL/min) and resistance (R, in Wood units [WU]) can be measured invasively by continuous thermodilution. The aim of this study was to assess normal reference values of Q and R. In 177 arteries (69 patients: 25 controls, i.e., without identifiable coronary atherosclerosis; 44 patients with mild, non-obstructive atherosclerosis), thermodilution-derived hyperaemic Q and total, epicardial, and microvascular absolute resistances (Rtot, Repi, and Rmicro) were measured. In 20 controls and 29 patients, measurements were obtained in all three major coronary arteries, thus allowing calculations of Q and R for the whole heart. In 15 controls (41 vessels) and 25 patients (71 vessels), vessel-specific myocardial mass was derived from coronary computed tomography angiography. Whole heart hyperaemic Q tended to be higher in controls compared to patients (668±185 vs 582±138 mL/min, p=0.068). In the left anterior descending coronary artery (LAD), hyperaemic Q was significantly higher (293±102 mL/min versus 228±71 mL/min, p=0.004) in controls than in patients. This was driven mainly by a difference in Repi (43±23 vs 83±41 WU, p=0.048), without significant differences in Rmicro. After adjustment for vessel-specific myocardial mass, hyperaemic Q was similar in the three vascular territories (5.9±1.9, 4.9±1.7, and 5.3±2.1 mL/min/g, p=0.44, in the LAD, left circumflex and right coronary artery, respectively). The present report provides reference values of absolute coronary hyperaemic Q and R. Q was homogeneously distributed in the three major myocardial territories but the large ranges of observed hyperaemic values of flow and of microvascular resistance preclude their clinical use for inter-patient comparison.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33016881; info:eu-repo/semantics/altIdentifier/eissn/1969-6213; https://serval.unil.ch/notice/serval:BIB_8A46898C06C4Test; urn:issn:1774-024X

الإتاحة: https://doi.org/10.4244/EIJ-D-20-00684Test
https://serval.unil.ch/notice/serval:BIB_8A46898C06C4Test

المؤلفون: Ohki, E., Kato, S., Ohgo, H., Mizukami, T., Fukuda, M., Tamai, H., Okamura, Y., Matsumoto, M., Suzuki, H., Yokoyama, H., Ishii, H.

المصدر: Alcoholism: Clinical & Experimental Research; May1998 Supplement S3, Vol. 22, p129S-132S, 1p