المؤلفون: Yusuke Masuo, Hiroshi Arakawa, Yukio Kato, Noritaka Nakamichi, Takumi Kawanishi

المصدر: Journal of Pharmaceutical Sciences. 108:3130-3137

مصطلحات موضوعية: Male, ATP Binding Cassette Transporter, Subfamily B, medicine.drug_class, Administration, Oral, Pharmaceutical Science, 02 engineering and technology, Pharmacology, digestive system, 030226 pharmacology & pharmacy, Intestinal absorption, Tyrosine-kinase inhibitor, Mice, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Oral administration, medicine, ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, Humans, Intestinal Mucosa, Cholestasis, Intestinal permeability, Microvilli, Chemistry, Bile duct, Cell Membrane, Imatinib, 021001 nanoscience & nanotechnology, medicine.disease, Up-Regulation, Disease Models, Animal, medicine.anatomical_structure, Intestinal Absorption, Imatinib Mesylate, Administration, Intravenous, 0210 nano-technology, Tyrosine kinase, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4379142fc0d1120bf3cd16514e184426Test
https://doi.org/10.1016/j.xphs.2019.05.017Test

المؤلفون: Ikumi Tamai, Hiroshi Arakawa, Shijie Wen

المصدر: Biochemical and biophysical research communications. 581

مصطلحات موضوعية: Male, Gout, THP-1 Cells, Interleukin-1beta, Primary Cell Culture, Biophysics, Inflammation, Hyperuricemia, CD38, Nicotinamide adenine dinucleotide, Biochemistry, Models, Biological, chemistry.chemical_compound, Mice, medicine, Animals, Humans, Molecular Biology, chemistry.chemical_classification, Membrane Glycoproteins, Cluster of differentiation, Macrophages, hemic and immune systems, Cell Biology, medicine.disease, NAD, ADP-ribosyl Cyclase 1, Cell biology, Uric Acid, Mice, Inbred C57BL, Enzyme, chemistry, Gene Expression Regulation, Female, NAD+ kinase, medicine.symptom, Crystallization, Intracellular, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b952d5c585edbca1bd84e9bb0e4fbbTest
https://pubmed.ncbi.nlm.nih.gov/34637964Test

المؤلفون: Yusuke Kato, Marie Shinohara, Yukio Kato, Tomoki Nakatsuji, Manami Mitsuta, Yuuichi Oda, Takumi Kawanishi, Sylvia Leo, Keita Iino, Hiroshi Arakawa, Hiroshi Kimura, Wataru Nihei, Kenta Shinha, Shoen Kume, Tomomi Goto, Takumi Nishiuchi, Toshiyuki Kanamori, Kosuke Inamura, Nobuaki Shiraki, Masaki Nishikawa, Taku Satoh, Karin Araya, Shinji Sugiura, Kikuo Komori, Yasuyuki Sakai

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Drug, media_common.quotation_subject, Science, Induced Pluripotent Stem Cells, Drug Evaluation, Preclinical, 02 engineering and technology, Article, Mice, 03 medical and health sciences, Downregulation and upregulation, In vivo, Lab-On-A-Chip Devices, Pressure, Animals, Humans, Gene, media_common, Multidisciplinary, Chemistry, Biological techniques, Albumin, Metabolism, Microfluidic Analytical Techniques, 021001 nanoscience & nanotechnology, Coculture Techniques, In vitro, Cell biology, Human hepatocyte, 030104 developmental biology, Hepatocytes, Medicine, 0210 nano-technology, Biotechnology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e97fbbe5db5cadc517099519d2d84fTest
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100856406Test

المؤلفون: Hiroshi, Arakawa, Hiroyuki, Yamada, Kazutaka, Arai, Takumi, Kawanishi, Nobuhiro, Nitta, Sayaka, Shibata, Eiko, Matsumoto, Kentaro, Yano, Yukio, Kato, Takuya, Kumamoto, Ichio, Aoki, Takuo, Ogihara

المصدر: International journal of pharmaceutics. 586

مصطلحات موضوعية: Male, Symporters, Biological Transport, Dipeptides, Peptide Transporter 1, Fluorine-19 Magnetic Resonance Imaging, Mice, Inbred C57BL, Mice, HEK293 Cells, Neoplasms, Hepatocytes, Toxicity Tests, Acute, Animals, Humans, Tissue Distribution, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::c88955e3612a8d984bf95b9bf8ed3968Test
https://pubmed.ncbi.nlm.nih.gov/32622809Test

المؤلفون: Hiroshi Arakawa, Masayuki Kato, Sadamu Homma, Keiichi Ikeda, Masafumi Chiba, Hiroo Imazu, Kazuki Sumiyama, Tomohiro Kato

المصدر: Oncology Reports

مصطلحات موضوعية: Male, Endoscopic ultrasound, Cancer Research, Pathology, Pilot Projects, Mice, 0302 clinical medicine, Neoplasms, Cytology, Medicine, endoscopic ultrasound-guided fine needle aspiration, Aged, 80 and over, quantitative analysis, medicine.diagnostic_test, Area under the curve, clinical trial, Articles, General Medicine, Middle Aged, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Fine-needle aspiration, Oncology, 030220 oncology & carcinogenesis, Adenocarcinoma, Female, 030211 gastroenterology & hepatology, Adenoma, Adult, medicine.medical_specialty, Cytodiagnosis, 03 medical and health sciences, Cell Line, Tumor, pancreatic adenocarcinoma, Animals, Humans, Aged, Receiver operating characteristic, business.industry, Calcium-Binding Proteins, Cancer, medicine.disease, Xenograft Model Antitumor Assays, digestive system diseases, Confidence interval, Pancreatic Neoplasms, body regions, S100P protein, business, Nuclear medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dccda32e2b3b92a66c7db5c56b8052dTest
https://doi.org/10.3892/or.2017.5471Test

المؤلفون: Takuo Ogihara, Hajime Kojima, Satoshi Koyama, Kentaro Yano, Tomoko Jomura, Hiroshi Arakawa, Hiroki Kamioka, Yoko Idota

المصدر: Biologicalpharmaceutical bulletin. 40(7)

مصطلحات موضوعية: 0301 basic medicine, CYP2B6, Pharmaceutical Science, primary human hepatocyte, Pharmacology, 030226 pharmacology & pharmacy, 03 medical and health sciences, Mice, 0302 clinical medicine, Cytochrome P-450 Enzyme System, three-dimensional culture, Constitutive androstane receptor, medicine, Animals, Humans, Receptor, induction, drug-metabolizing enzyme, Cells, Cultured, Pregnane X receptor, biology, Chemistry, CYP1A2, General Medicine, 3T3 Cells, Aryl hydrocarbon receptor, Molecular biology, Enzyme assay, 030104 developmental biology, medicine.anatomical_structure, Pharmaceutical Preparations, spheroid, Hepatocyte, Enzyme Induction, biology.protein, Hepatocytes, Chemical and Drug Induced Liver Injury, drug-induced liver injury

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428cd03aa2a3a2437dba4f25066a428dTest
https://pubmed.ncbi.nlm.nih.gov/28674261Test

المؤلفون: Ken-ichi Fujita, Hiroshi Arakawa, Hiroo Ishida, Noritaka Nakamichi, Ramadan Abdelwahed, Yukio Kato, Waleed Elsayed Ahmed Ellawatty, Yusuke Masuo, Yasutsuna Sasaki, Erina Yamazaki

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 46(1)

مصطلحات موضوعية: Male, Indazoles, Liver cytology, medicine.drug_class, Pharmaceutical Science, Pharmacology, Transfection, 030226 pharmacology & pharmacy, Tyrosine-kinase inhibitor, Pazopanib, 03 medical and health sciences, Inhibitory Concentration 50, Mice, 0302 clinical medicine, Cyclosporin a, medicine, Animals, Humans, Tissue Distribution, IC50, Protein Kinase Inhibitors, Mice, Inbred ICR, Sulfonamides, Organic cation transport proteins, biology, Chemistry, Transporter, Metformin, Quaternary Ammonium Compounds, HEK293 Cells, Pyrimidines, Liver, 030220 oncology & carcinogenesis, biology.protein, Cyclosporine, Hepatocytes, Administration, Intravenous, medicine.drug, Octamer Transcription Factor-1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae1b06bb76353e211fbc039dbc11324Test
https://pubmed.ncbi.nlm.nih.gov/29089306Test

المؤلفون: David G. Schatz, Jessica J. McDonald, Jean-Marie Buerstedde, Jukka Alinikula, Hiroshi Arakawa

المصدر: PLoS Biology
PLoS Biology, Vol 12, Iss 4, p e1001831 (2014)

مصطلحات موضوعية: B Cells, Transcription, Genetic, Lymphocyte Activation, Biochemistry, E-Box Elements, White Blood Cells, Gene Knockout Techniques, Mice, 0302 clinical medicine, Animal Cells, Nucleic Acids, Molecular Cell Biology, Biology (General), Immune Response, 0303 health sciences, B-Lymphocytes, Immune System Proteins, MEF2 Transcription Factors, General Neuroscience, NF-kappa B, Cytidine deaminase, 3. Good health, Enhancer Elements, Genetic, Cellular Types, General Agricultural and Biological Sciences, DNA modification, Research Article, QH301-705.5, Immune Cells, DNA transcription, Immunology, Green Fluorescent Proteins, Somatic hypermutation, Biology, General Biochemistry, Genetics and Molecular Biology, Antibodies, Cell Line, Affinity maturation, 03 medical and health sciences, Immunoglobulin kappa-Chains, Immunoglobulin lambda-Chains, Cytidine Deaminase, Genetics, Animals, Humans, Enhancer, Uracil-DNA Glycosidase, Gene, Transcription factor, 030304 developmental biology, Blood Cells, Binding Sites, General Immunology and Microbiology, Biology and life sciences, Point mutation, Proteins, DNA, Cell Biology, Molecular biology, Mutation, Gene expression, Somatic Hypermutation, Immunoglobulin, Chickens, Sequence Alignment, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a2c7f03381e457777efb988037e9aaTest
http://europepmc.org/articles/PMC3972084Test

المؤلفون: Shunichi Takeda, Hiroshi Arakawa

المصدر: International Immunology. 8:1319-1328

مصطلحات موضوعية: Time Factors, Transgene, Immunology, Cell, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Gene Expression, Receptors, Antigen, B-Cell, Mice, Transgenic, Mice, medicine, Animals, Gene Rearrangement, B-Lymphocyte, Light Chain, Immunology and Allergy, B cell, B-Lymphocytes, biology, Immunoglobulin mu-Chains, Chemistry, Hematopoietic Stem Cell Transplantation, Cell Differentiation, General Medicine, Gene rearrangement, Hematopoietic Stem Cells, Molecular biology, Mice, Inbred C57BL, Haematopoiesis, medicine.anatomical_structure, Immunoglobulin M, biology.protein, Immunoglobulin heavy chain, Antibody, Stem cell

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b2311ac1614a0585cc55e37a53ac78Test
https://doi.org/10.1093/intimm/8.8.1319Test

المؤلفون: Alena Bencsik-Theilen, Minli Wang, Emil Mladenov, Katja Paul, Theresa Bednar, George Iliakis, Hiroshi Arakawa

المصدر: Nucleic Acids Research
Nucleic Acids Res. 40, 2599-2610 (2012)

مصطلحات موضوعية: DNA Replication, DNA Ligases, Cell Survival, Medizin, Eukaryotic DNA replication, Biology, Xenopus Proteins, LIG1, Cell Line, DNA Ligase ATP, Gene Knockout Techniques, Control of chromosome duplication, Genetics, EMBRYONIC LETHALITY, DEFECTIVE NEUROGENESIS, MAMMALIAN-CELLS, EXCISION-REPAIR, GENE, NUCLEAR, RECOMBINATION, PROTEIN, SITES, MICE, Animals, Poly-ADP-Ribose Binding Proteins, chemistry.chemical_classification, DNA ligase, DNA clamp, Okazaki fragments, Nucleic Acid Enzymes, DNA replication, Molecular biology, Mitochondria, chemistry, Gene Targeting, Mutation, Genes, Lethal, Chickens, Nucleotide excision repair

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a927ebd6cc5f3c184fdfbd57e8ec03edTest
https://www.ncbi.nlm.nih.gov/pubmed/22127868Test