المؤلفون: Kit-Kay Mak, Zhang Shiming, Jun Sheng Low, Madhu Katyayani Balijepalli, Raghavendra Sakirolla, Albena T. Dinkova-Kostova, Ola Epemolu, Zulkefeli Mohd, Mallikarjuna Rao Pichika

المصدر: Molecules; Volume 27; Issue 15; Pages: 4992

مصطلحات موضوعية: Flavonoids, Lipopolysaccharides, Glycogen Synthase Kinase 3 beta, Kelch-Like ECH-Associated Protein 1, NF-E2-Related Factor 2, Organic Chemistry, Anti-Inflammatory Agents, NF-kappa B, Pharmaceutical Science, Nitric Oxide, Amides, Rats, Analytical Chemistry, Molecular Docking Simulation, Mice, Chemistry (miscellaneous), Drug Discovery, Animals, Cytokines, Humans, Molecular Medicine, Physical and Theoretical Chemistry, Heme Oxygenase-1, auranamide, patriscabratine, Melastoma malabathricum, NRF2, KEAP1, anti-inflammatory

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8826c704a8ff88a56dc443453de3304cTest

المؤلفون: Steven O′Reilly, Albena T. Dinkova-Kostova, John Henderson, Sharadha Dayalan Naidu, Stefan Przyborski, Richard Stratton

المصدر: Cells, 2021, Vol.10(8) [Peer Reviewed Journal]
Cells; Volume 10; Issue 8; Pages: 2053
Cells
Cells, Vol 10, Iss 2053, p 2053 (2021)

مصطلحات موضوعية: QH301-705.5, systemic sclerosis, NF-E2-Related Factor 2, medicine.medical_treatment, Down-Regulation, Article, Nrf2, Transforming Growth Factor beta1, Mice, Downregulation and upregulation, Fibrosis, medicine, NAD(P)H Dehydrogenase (Quinone), Animals, Humans, Biology (General), Interleukin 6, chemistry.chemical_classification, Mice, Knockout, Reactive oxygen species, Scleroderma, Systemic, biology, integumentary system, Interleukin-6, fibrosis, Connective Tissue Growth Factor, Succinates, General Medicine, Transforming growth factor beta, Fibroblasts, medicine.disease, C700, Connective tissue disease, Molecular biology, Antioxidant Response Elements, Up-Regulation, Heme oxygenase, MicroRNAs, Cytokine, chemistry, itaconate, biology.protein, metabolism, Collagen, Reactive Oxygen Species, Heme Oxygenase-1

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca68670e6790373ccb3a2ff9f8bbf0fTest
http://dro.dur.ac.uk/35213Test/

المؤلفون: Albena T. Dinkova-Kostova, Aiten M. Soliman, Mai H. Mekkawy, Mostafa M. Ghorab, Heba M. Karam, Maureen Higgins

المصدر: European Journal of Medicinal Chemistry

مصطلحات موضوعية: Male, Antioxidant, Stereochemistry, medicine.medical_treatment, Thio, Sulfonamide, 01 natural sciences, Antioxidants, Article, Nrf2, Docking, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Discovery, medicine, NAD(P)H Dehydrogenase (Quinone), Tumor Cells, Cultured, Moiety, Animals, Inducer, Quinazolinone, 030304 developmental biology, Quinazolinones, Diiodoquinazolinone, Pharmacology, chemistry.chemical_classification, 0303 health sciences, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, General Medicine, 0104 chemical sciences, Molecular Docking Simulation, Enzyme, chemistry, Radiomodulatory, Docking (molecular), Oxidative stress, NQO1, Acetamide

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d736d50f9c5871172e527050e1895228Test
https://pubmed.ncbi.nlm.nih.gov/32502866Test

المؤلفون: Albena T. Dinkova-Kostova, Filip Cvetko, Hiran A. Prag, Michael P. Murphy, Stuart T. Caldwell, Maureen Higgins, Takafumi Suzuki, Richard C. Hartley, Masayuki Yamamoto

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, GCLC, glutamate–cysteine ligase catalytic subunit, thiol oxidation, Mitochondrion, Biochemistry, FB, fractionation buffer, NQO1, NAD(P)H:quinone oxidoreductase-1, Mice, chemistry.chemical_compound, DNM1L, Superoxides, energy metabolism, Homeostasis, Hydrogen peroxide, Cells, Cultured, HO-1, heme oxygenase-1, NAC, N-acetyl-L-cysteine, SFN, sulforaphane, chemistry.chemical_classification, Kelch-Like ECH-Associated Protein 1, Nrf2, nuclear factor erythroid 2–related factor 2, respiratory system, DRP1, dynamin-related protein 1, Glutathione, Mitochondria, Cell biology, CDNB, 1-chloro-2,4-dinitrobenzene, Keap1, Kelch-like ECH-associated protein 1, TRX, thioredoxin, Thioredoxin, Oxidation-Reduction, Research Article, Signal Transduction, NF-E2-Related Factor 2, reactive oxygen species (ROS), Nrf2, MitoPQ, MitoParaquat, 03 medical and health sciences, MitoCDNB, CD, concentration required to double, ROS, reactive oxygen species, PGAM5, phosphoglycerate mutase family member 5, Animals, TRXR2, TRX reductase 2, Cysteine, Sulfhydryl Compounds, redox signaling, Molecular Biology, Reactive oxygen species, 030102 biochemistry & molecular biology, Cell Biology, ACN, acetonitrile, MitoCDNB, MitoChlorodinitrobenzoic acid, GSS, GSH synthetase, MEF, mouse embryonic fibroblast, KEAP1, 030104 developmental biology, chemistry, BSA, bovine serum albumin, MitoPQ

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0523882756133409621203d90cd5225Test
https://doi.org/10.1074/jbc.ra120.016551Test

المؤلفون: Lenka, Roubalová, Albena T, Dinkova-Kostova, David, Biedermann, Vladimír, Křen, Jitka, Ulrichová, Jiří, Vrba

المصدر: Fitoterapia

مصطلحات موضوعية: NF-E2-Related Factor 2, Glutamate-Cysteine Ligase, NQO1, NAD(P)H:quinone oxidoreductase 1, Gene Expression, ARE, antioxidant response element, Gapdh, glyceraldehyde-3-phosphate dehydrogenase, DMSO, dimethyl sulfoxide, SC, silychristin, Article, Nrf2, DHSD, 2,3-dehydrosilydianin, SB, silybin, Mice, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Silybum marianum, ROS, reactive oxygen species, Cell Line, Tumor, NAD(P)H Dehydrogenase (Quinone), Nrf2/NFE2L2, NF-E2 p45-related factor 2, Animals, Humans, Milk Thistle, DHSC, 2,3-dehydrosilychristin, SFN, sulforaphane, Molecular Structure, HMOX1, heme oxygenase-1, Membrane Proteins, SD, silydianin, GCLM, glutamate-cysteine ligase modifier subunit, Up-Regulation, Keap1, Kelch-like ECH-associated protein 1, Flavonolignans, Silybin, NQO1, DHSB, 2,3-dehydrosilybin, Heme Oxygenase-1, GCLC, glutamate-cysteine ligase catalytic subunit, Silymarin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::99487d2bc78654f7342479f183a8f101Test
https://pubmed.ncbi.nlm.nih.gov/28450126Test

المؤلفون: Lenka, Roubalová, David, Biedermann, Barbora, Papoušková, Jan, Vacek, Marek, Kuzma, Vladimír, Křen, Jitka, Ulrichová, Albena T, Dinkova-Kostova, Jiří, Vrba

المصدر: Chemico-Biological Interactions

مصطلحات موضوعية: Cell Survival, NF-E2-Related Factor 2, NQO1, NAD(P)H:quinone oxidoreductase 1, Methyl gallate, ARE, antioxidant response element, Gapdh, glyceraldehyde-3-phosphate dehydrogenase, DMSO, dimethyl sulfoxide, p38 Mitogen-Activated Protein Kinases, Mass Spectrometry, Article, Nrf2, Mice, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, ROS, reactive oxygen species, ERK, extracellular signal-regulated kinase, Genes, Reporter, Cell Line, Tumor, Quercetin-7-gallate, HO-1/Hmox1, heme oxygenase-1, NAD(P)H Dehydrogenase (Quinone), Animals, Humans, heterocyclic compounds, Nrf2, NF-E2 p45-related factor 2, Protein Kinase Inhibitors, Biotransformation, NAC, N-acetyl-l-cysteine, GCLM, glutamate-cysteine ligase modifier subunit, Keap1, Kelch-like ECH-associated protein 1, RAW 264.7 Cells, Metabolism, Gene Expression Regulation, Heme oxygenase-1, Enzyme Induction, JNK, c-Jun N-terminal kinase, Metabolome, p38 MAPK, p38 mitogen-activated protein kinase, Quercetin, Reactive Oxygen Species, GCLC, glutamate-cysteine ligase catalytic subunit, MAPK, mitogen-activated protein kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::7e6fbf86ca95d28c7e05d0f312bfa175Test
https://pubmed.ncbi.nlm.nih.gov/27777014Test

المؤلفون: Kusal T. G. Samarasinghe, Young Hoon Ahn, Philip A. Cole, Ying Zhang, A. Pheely, G. C. Van Hecke, Albena T. Dinkova-Kostova, Ivor J. Benjamin, Robert N. Cole, Tatiana Boronina, S. Dayalan Naidu

المصدر: British Journal of Cancer

مصطلحات موضوعية: Cancer Research, Molecular Sequence Data, Hsp90, Breast Neoplasms, HSP72 Heat-Shock Proteins, Cell Growth Processes, Biology, HSF1, NRF2, Hsp90 inhibitor, Mice, 03 medical and health sciences, chemistry.chemical_compound, Adenosine Triphosphate, 0302 clinical medicine, Cell Line, Tumor, Heat shock protein, Animals, Humans, Amino Acid Sequence, Cysteine, HSP90 Heat-Shock Proteins, Molecular Targeted Therapy, Sulfhydryl Compounds, Cysteine metabolism, 030304 developmental biology, Mice, Knockout, 0303 health sciences, Neoplasm Proteins, Up-Regulation, 3. Good health, Proteostasis, Oncology, chemistry, Biochemistry, Sulfoxides, 030220 oncology & carcinogenesis, Chaperone (protein), MCF-7 Cells, biology.protein, Female, Carbamates, Translational Therapeutics, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1597f50dd6ab1eaf2bac1a922b2242adTest
https://doi.org/10.1038/bjc.2013.710Test

المؤلفون: Sam Swift, Albena T. Dinkova-Kostova, Liam Baird, David Llères

المساهمون: Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)

المصدر: Biotechnology Advances
Biotechnology Advances, Elsevier, 2014, 32 (6), pp.1133-1144. ⟨10.1016/j.biotechadv.2014.03.004⟩

مصطلحات موضوعية: FLIM, Keap1, RBX1, [SDV]Life Sciences [q-bio], Bioengineering, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Applied Microbiology and Biotechnology, environment and public health, Nrf2, Cell Line, chemistry.chemical_compound, Mice, Fluorescence Resonance Energy Transfer, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Transcription factor, [SDV.BDD]Life Sciences [q-bio]/Development Biology, Binding Sites, Kelch-Like ECH-Associated Protein 1, Intracellular Signaling Peptides and Proteins, Signal transducing adaptor protein, respiratory system, Cell biology, Ubiquitin ligase, Rats, Förster resonance energy transfer, chemistry, NF-E2 Transcription Factor, p45 Subunit, Isothiocyanate, Research Review Paper, biology.protein, FRET, Cytoprotective enzymes, Signal transduction, Single-Cell Analysis, Sulforaphane, Biotechnology, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31380384f18f256d2657d8ed42bafedTest
https://hal.archives-ouvertes.fr/hal-03027057Test

المؤلفون: Stjepana, Kovac, Plamena R, Angelova, Kira M, Holmström, Ying, Zhang, Albena T, Dinkova-Kostova, Andrey Y, Abramov

المصدر: Biochimica et Biophysica Acta

مصطلحات موضوعية: Mice, Hairless, Keap1, Kelch-Like ECH-Associated Protein 1, NADPH oxidase, NF-E2-Related Factor 2, Intracellular Signaling Peptides and Proteins, NADPH Oxidases, ROS, NOX, respiratory system, digestive system, environment and public health, Article, Nrf2, Mitochondria, Mice, Cytosol, Animals, Reactive Oxygen Species

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::df45a0e67812789299dbd6b553ef55cdTest
https://pubmed.ncbi.nlm.nih.gov/25484314Test

المؤلفون: Joanne Walsh, Christopher E. Goldring, Alex Odermatt, B. Kevin Park, Luke M. Shelton, Tadashi Honda, Adam Lister, Albena T. Dinkova-Kostova, Denise V. Kratschmar, Ian M. Copple

المصدر: Toxicological Sciences

مصطلحات موضوعية: NF-E2-Related Factor 2, Pharmacology, In Vitro Techniques, Toxicology, digestive system, environment and public health, Nrf2, Cell Line, chemistry.chemical_compound, Mice, Therapeutic index, Potency, Animals, Humans, Inducer, Bardoxolone methyl, Chemistry, respiratory system, triterpenoids, KEAP1, Small molecule, Triterpenes, 3. Good health, Rats, therapeutic index, Signal transduction, Sulforaphane, Safety Evaluation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b416ab20c1d44af77421e435202ed583Test
https://pubmed.ncbi.nlm.nih.gov/24798383Test