التفاصيل البيبلوغرافية
| العنوان: |
Clinical and microbiological characterization of Aerococcus urinae bacteraemias at Helsinki metropolitan area, Finland. |
| المؤلفون: |
Sihvonen, Reetta, Turunen, Maria, Lehtola, Laura, Pakarinen, Laura, Grönroos, Juha O., Rantakokko-Jalava, Kaisu, Pätäri-Sampo, Anu |
| المصدر: |
European Journal of Clinical Microbiology & Infectious Diseases; May2022, Vol. 41 Issue 5, p751-760, 10p |
| مصطلحات موضوعية: |
CEFUROXIME, MICROBIAL sensitivity tests, ANTI-infective agents, CEFTRIAXONE, URINARY organs, METROPOLITAN areas, MEDICAL records |
| مصطلحات جغرافية: |
HELSINKI (Finland), FINLAND |
| مستخلص: |
Our objective was to assess the incidence of bacteraemic Aerococcus urinae cases at Helsinki metropolitan area, Finland, from a 6-year study period (2013 to 2018) and to further characterize available cases. The study evaluates the outcome of commonly used cefuroxime treatment and determinate a set of A. urinae in vitro antimicrobial susceptibilities for benzylpenicillin, cefuroxime, and ceftriaxone. Clinical records of A. urinae bacteraemic patients were reviewed retrospectively. Antimicrobial susceptibility testing was performed by disk diffusion, gradient test, and broth microdilution for 139–141 clinical A. urinae isolates. Clinical data of 72/77 patients were combined with the in vitro susceptibilities. We found an increasing number of bacteraemic A. urinae cases within 6-year study period (p = 0.01). The patients were mainly elderly males, and all suffered from underlying conditions. A total of 27.3% of cases (21/77) showed polymicrobial blood cultures. Thirty-day mortality was 22.1%. Cefuroxime was the initial empiric antimicrobial agent given for 66/76 of the patients and treatment outcome was favorable for 20/22 patients who received cefuroxime at least up to day 5. All isolates were susceptible to benzylpenicillin and cefuroxime interpreted by EUCAST breakpoints for Aerococci and PK-PD breakpoints, respectively. MIC determinations gave variable results for ceftriaxone, 2.1–2.9% of the isolates were resistant. To conclude, it seems that the number of bacteraemic Aerococcus urinae cases is increasing at Helsinki metropolitan area, Finland, reflecting the growing blood culture sampling. Clinical A. urinae isolates were susceptible to cefuroxime in vitro. Treatment data indicate that empirical cefuroxime started for possibly urinary tract -derived community-acquired bacteraemia covers A. urinae. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
