المؤلفون: Manabu Yamashita, Sohsuke Yamada, Akihiro Shioya, Satoko Nakada, Hiroshi Minato, Mariko Nakano, Xin Guo, Nozomu Kurose

المصدر: Diagnostic Pathology, Vol 13, Iss 1, Pp 1-4 (2018)
Diagnostic Pathology

مصطلحات موضوعية: Male, Pathology, medicine.medical_specialty, Skin Neoplasms, Histology, Biopsy, Fine-Needle, Case Report, Pathology and Forensic Medicine, Metastasis, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, Predictive Value of Tests, Cytology, Proliferating pilomatricoma, Carcinoma, lcsh:Pathology, Humans, Medicine, Diagnostic Errors, Cell Proliferation, business.industry, Nodule (medicine), Pilomatricoma, General Medicine, Middle Aged, Pilomatrixoma, medicine.disease, Hair follicle, Magnetic Resonance Imaging, Basophilic cells, Parotid Neoplasms, Parotid gland, Basophilic, medicine.anatomical_structure, Shadow cells, 030220 oncology & carcinogenesis, medicine.symptom, Hair Diseases, business, lcsh:RB1-214

الوصف: Background Pilomatricoma is a relatively common benign cutaneous adnexal neoplasm with differentiation towards the hair matrix, inner sheath of hair follicle and hair cortex. Proliferating pilomatricoma is a rare variant of pilomatricoma that can rapidly increase and may be misidentified as a malignant tumor. We herein report the cytopathological findings of proliferating pilomatricoma misdiagnosed as a malignant parotid tumor. Case presentation A 64-year-old man noticed an acne-like nodule in the left parotid region. It was painless, but it increased to a maximum diameter of 4.5 cm over 2 years. Clinically, left parotid gland carcinoma was suspected, and fine-needle aspiration cytology was performed. Clusters of epithelial cells were observed in a necrotic background, and malignant epithelial cells derived from salivary glands were suspected. Histologically, the resected tumor was diagnosed as proliferating pilomatricoma composed of basophilic cells and shadow cells apart from the parotid gland. However, on a re-evaluation of the cytological specimens, the irregular-shaped epithelial cells were considered to be from basophilic cells. Shadow cells with nuclear disappearance were also confirmed. Tumor recurrence and metastasis have not been observed in the four years since surgery. Conclusion The present case was first interpreted as a malignant parotid gland tumor, but it was actually a benign skin appendage tumor. Pilomatricoma sometimes rapidly increases and may be mistaken for a malignant tumor. Although it is critical to recognize not only basophilic cells but also shadow cells, it cannot be diagnosed by cytological findings. The final diagnosis should be made on excision specimen only.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f886aa478ea0ddf148497d20660f8f9bTest
http://link.springer.com/article/10.1186/s13000-018-0738-4Test

المؤلفون: Hiroko Ikeda, Keishi Mizuguchi, Satoko Nakada, Tsubasa Shimoda

المصدر: The Journal of the Japanese Society of Clinical Cytology. 59:251-252

مصطلحات موضوعية: business.industry, Mixed adenoneuroendocrine carcinoma, Cancer research, medicine, medicine.disease, business, Metastasis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::34b5742cc049f20cdb858ec72d3c60d0Test
https://doi.org/10.5795/jjscc.59.251Test

المؤلفون: Jun Kinoshita, Satoko Nakada, Sachio Fushida, Hiroto Saito, Mari Shimada, Hidehiro Tajima, Koichi Okamoto, Yasutsugu Mizuno, Hideki Moriyama, Keishi Nakamura, Takahisa Yamaguchi, Shiro Terai, Itasu Ninomiya

المصدر: SAGE Open Medical Case Reports
SAGE Open Medical Case Reports, Vol 9 (2021)

مصطلحات موضوعية: Medicine (General), Pathology, medicine.medical_specialty, Stromal cell, Case Report, ovarian metastasis, Metastasis, 03 medical and health sciences, Ovarian tumor, R5-920, 0302 clinical medicine, Medicine, Gastric Gastrointestinal Stromal Tumor, Stromal tumor, Gastrointestinal tract, business.industry, Imatinib, General Medicine, medicine.disease, imatinib, neo adjuvant chemotherapy, 030220 oncology & carcinogenesis, Pelvic tumor, 030211 gastroenterology & hepatology, business, GIST, medicine.drug

الوصف: Gastrointestinal stromal tumors are common mesenchymal tumors of the gastrointestinal tract. The major site of metastasis for gastrointestinal stromal tumors is the liver or peritoneum, while metastasis to the ovary is exceptionally rare. A 53-year-old woman visited the hospital for bloating and anorexia and was diagnosed with a huge gastric gastrointestinal stromal tumor and peritoneal metastasis in the pelvis on upper gastrointestinal endoscopy and abdominal enhanced computed tomography. After administration of imatinib, the tumor was significantly reduced, and we performed laparoscopic pelvic tumor resection and open proximal gastrectomy with transverse colectomy. Intraoperatively, the pelvic tumor was found to be an ovarian tumor. Microscopic examination confirmed a gastric gastrointestinal stromal tumor with ovarian metastasis. In conclusion, we experienced a rare case of gastric gastrointestinal stromal tumor with ovarian metastasis. Preoperative administration of imatinib was successful and radical resection was achieved. Although pelvic tumors are difficult to differentiate preoperatively, the possibility of ovarian metastasis from gastrointestinal stromal tumor should be considered.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d27807d08c50ef91a985974dba0527bTest
https://doi.org/10.1177/2050313x211012511Test

المؤلفون: Masaaki Kobayashi, Yasuo Sasagawa, Satoko Nakada, Yukihiko Kohda, Mitsutoshi Nakada

المصدر: Surgical Neurology International; 2022, Vol. 13, p1-3, 3p

مصطلحات موضوعية: PROSTATE cancer, PROSTATE, MENINGIOMA, MAGNETIC resonance imaging, METASTASIS, CARCINOMA

مستخلص: Background: Prostate carcinoma rarely metastasizes to the central nervous system. However, when it does, a dural lesion is a common and possible misdiagnosis of meningioma. Here, we describe a case of a 77-year-old man with dural metastasis from prostate carcinoma of the tuberculum sellae. Case Description: The patient was diagnosed with prostate carcinoma 7 years previously and was well-controlled by hormone therapy. He was incidentally found to have a suprasellar tumor and underwent endoscopic endonasal transsphenoidal surgery because of rapid tumor growth and worsening visual impairment. Since his serum prostate-specific antigen (PSA) level was within the normal range, malignant meningioma was suspected based on the magnetic resonance imaging (MRI) and the course. However, the pathological findings revealed dural metastasis from prostate carcinoma. He received radiation therapy, and the tumor disappeared on MRI. His visual impairment improved without recurrence. This case report highlights that dural metastasis of the tuberculum sellae arose despite the patient's PSA level being within the normal range, and a single metastasis to the dura was found. Conclusion: In patients with a history of prostate carcinoma or older men, careful follow-up considering the possibility of metastasis is required when a dural lesion is found. [ABSTRACT FROM AUTHOR]

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المؤلفون: Takayuki Nojima, Hiroshi Minato, Satoko Nakada

المصدر: Brain tumor pathology. 33(3)

مصطلحات موضوعية: Adult, Male, endocrine system, Cancer Research, Solitary fibrous tumor, Pathology, medicine.medical_specialty, Time Factors, Adolescent, NAB2/STAT6 Fusion Gene, Biology, Metastasis, Fusion gene, 03 medical and health sciences, Exon, Young Adult, 0302 clinical medicine, parasitic diseases, medicine, Meningeal Neoplasms, Humans, Child, Genetic Association Studies, Aged, Hemangiopericytoma, Aged, 80 and over, NAB2, integumentary system, Meninges, Genetic Variation, General Medicine, respiratory system, Middle Aged, medicine.disease, Repressor Proteins, medicine.anatomical_structure, Oncology, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Solitary Fibrous Tumors, Cancer research, Female, Neurology (clinical), Gene Fusion, STAT6 Transcription Factor, 030217 neurology & neurosurgery, Follow-Up Studies

الوصف: Investigations on the NAB2–STAT6 fusion gene in solitary fibrous tumors (SFTs) and hemangiopericytomas (HPCs) have increased since its discovery in 2013. Although several SFTs reported without NAB2–STAT6 fusion gene analysis, we reviewed 546 SFTs/HPCs with NAB2–STAT6 fusion gene analysis in this study and investigated differences between the gene variants. In total, 452 cases tested positive for the NAB2–STAT6 fusion gene, with more than 40 variants being detected. The most frequent of these were NAB2 exon 6-STAT6 exon 16/17/18 and NAB2 exon 4-STAT6 exon 2/3, with the former occurring most frequently in SFTs in meninges, soft tissues, and head and neck; the latter predominated in SFTs in the pleura and lung. There was no difference between the histology of SFTs and fusion gene variants. A follow-up analysis of SFTs showed that 51 of 202 cases had a recurrence, with 18 of 53 meningeal SFTs having a local recurrence and/or metastasis within 0–19 years. In meninges and soft tissue, SFTs with the NAB2 exon 6-STAT6 exon 16/17/18 tended to recur more frequently than SFTs with the NAB2 exon 4-STAT6 exon 2/3. Clinicopathological data, including yearly follow-ups, are required for meningeal SFTs/HPCs to define the correlation of variants of NAB2–STAT6 fusion gene.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b706ffaf4ef712579d5841c3bb2c7cTest
https://pubmed.ncbi.nlm.nih.gov/27271270Test

المؤلفون: Hiroko Ikeda, Takashi Kato, Hiroshi Minato, Takuya Akai, Norio Yamamoto, Tsutomu Takegami, Masako Kobayashi, Nozomu Kurose, Takayuki Nojima, Yasuo Sasagawa, Satoko Nakada

المصدر: Brain tumor pathology. 32(4)

مصطلحات موضوعية: Adult, Male, endocrine system, Cancer Research, Solitary fibrous tumor, Pathology, medicine.medical_specialty, Lung Neoplasms, Bone Neoplasms, NAB2/STAT6 Fusion Gene, Biology, Skull Base Neoplasms, Metastasis, Fusion gene, Exon, parasitic diseases, medicine, Humans, Nuclear atypia, Cerebellar Neoplasms, Aged, Hemangiopericytoma, Cranial Fossa, Middle, integumentary system, General Medicine, Exons, respiratory system, medicine.disease, Primary tumor, Immunohistochemistry, Repressor Proteins, Oncology, Cancer research, Female, Neurology (clinical), Gene Fusion, STAT6 Transcription Factor

الوصف: We present two cases of meningeal solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) with immunohistochemistry of STAT6 and analysis of NAB2–STAT6 fusion genes. Case 1 was a 37-year-old male with a left middle fossa tumor; case 2 was a 68-year-old female with a cerebellar tumor. They showed late metastasis to the lung or bone 8 or 13 years, respectively, after the first surgery. Histology of both primary and metastatic tumors showed a cellular hemangiopericytomatous pattern with nuclear atypia. The primary tumors showed nuclear staining of STAT6, but both metastatic tumors showed nuclear and cytoplasmic STAT6. DNA sequencing revealed two kinds of NAB2–STAT6 fusion genes. One consisted of exon 6 of NAB2, intron 6 of NAB2, and the middle of exon 17 of STAT6 (observed in the primary and metastatic tumors of case 1); the other consisted of exon 6 of NAB2 and the beginning of exon 17 of STAT6 (observed in the metastatic tumor of case 2). The primary tumor of case 2 had both fusion genes. To the best of our knowledge, we are the first to report NAB2–STAT6 fusion gene analysis in primary and metastatic meningeal SFT/HPCs and a case showed different fusion gene status in the metastatic tumor.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f6bc7803924c6806c712f65d72bda6Test
https://pubmed.ncbi.nlm.nih.gov/25893823Test