Effect of terminal N-substitution in 2-oxo-1,2-dihydroquinoline-3-carbaldehyde thiosemicarbazones on the mode of coordination, structure, interaction with protein, radical scavenging and cytotoxic activity of copper(ii) complexesElectronic supplementary information (ESI) available: Crystal packing diagram of the unit cell showing hydrogen bonding of 1, 2, 3and 4(Figures S1–S4), Emission spectra of binding of 1, 2and 3with Protein (Figures S5–S7), Absorption spectra of binding of 1, 2and 3with Protein (Figures S8–S10), Synchronous spectra (Δλ = 15 nm) of binding of 1, 2, 3and 4with Protein (Figures S11–S14), Synchronous spectra (Δλ = 60 nm) of binding of 1, 2and 3with Protein (Figures S15–S17). CCDC reference numbers 763001, 763002, 772056 and 772085. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c0dt01657h

التفاصيل البيبلوغرافية
العنوان:	Effect of terminal N-substitution in 2-oxo-1,2-dihydroquinoline-3-carbaldehyde thiosemicarbazones on the mode of coordination, structure, interaction with protein, radical scavenging and cytotoxic activity of copper(ii) complexesElectronic supplementary information (ESI) available: Crystal packing diagram of the unit cell showing hydrogen bonding of 1, 2, 3and 4(Figures S1–S4), Emission spectra of binding of 1, 2and 3with Protein (Figures S5–S7), Absorption spectra of binding of 1, 2and 3with Protein (Figures S8–S10), Synchronous spectra (Δλ = 15 nm) of binding of 1, 2, 3and 4with Protein (Figures S11–S14), Synchronous spectra (Δλ = 60 nm) of binding of 1, 2and 3with Protein (Figures S15–S17). CCDC reference numbers 763001, 763002, 772056 and 772085. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c0dt01657h
المؤلفون:	Duraisamy Senthil Raja¹, Ganesan Paramaguru², Nattamai S. P. Bhuvanesh¹, Joseph H. Reibenspies¹, Rajalingam Renganathan², Karuppannan Natarajan¹
المصدر:	Dalton Transactions: An International Journal of Inorganic Chemistry. Apr2011, Vol. 40 Issue 17, p4548-4559. 12p.
مصطلحات موضوعية:	THIOSEMICARBAZONES, SUBSTITUTION reactions, MOLECULAR structure, COPPER, METAL complexes, LIGANDS (Chemistry), COORDINATION compounds, X-ray diffraction
مستخلص:	Four 2-oxo-1,2-dihydroquinoline-3-carbaldehyde N-substituted thiosemicarbazone ligands (H2-OQtsc-R, where R = H, Me, Et or Ph) and their corresponding new copper(ii) complexes [CuCl2(H2-OQtsc-H)]·2H2O (1), [CuCl2(H2-OQtsc-Me)]·2H2O (2), [CuCl2(H2-OQtsc-Et)(CH3OH)]Cl (3) and [CuCl(H-OQtsc-Ph)]·CH3OH (4) have been synthesized in order to correlate the effect of terminal N-substitution on coordination behaviour, structure and biological activity. Single crystal X-ray diffraction studies revealed that the complexes 1, 2and 3have square pyramidal geometry around the central metal ion. In the complexes 1and 2, the copper ion is coordinated by the ligand with ONS donor atoms, one chloride ion in apical position and the other chloride in the basal plane. Complex 3consists of [CuCl2(H2-OQtsc-Et)(CH3OH)]+cation and a chloride as counter ion. The copper ion is coordinated by the ligand with ONS donor atoms and by one chloride ion in the basal plane. One methanol molecule is bonded through its neutral oxygen in the apical position. Complex 4is square planar with the ligand coordinating through uni-negative tridentate ONS−and by one chloride ion in the basal plane. The binding of complexes with lysozyme protein was carried out by fluorescence spectroscopy. Investigations of antioxidation properties showed that all the copper(ii) complexes have strong radical scavenging properties. The cytotoxicity of the complexes 3and 4against NIH 3T3 and HeLa cell lines showed that synergy between the metal and ligands results in a significant enhancement in the cell death with IC50of ∼10–40 μM. A size dependence of substitution at terminal N in the thiosemicarbazones on the biological activities of the complexes has been observed. [ABSTRACT FROM AUTHOR]
قاعدة البيانات:	Academic Search Index

الوصف
تدمد:	14779226
DOI:	10.1039/c0dt01657h