Metabolic portraits of breast cancer by HR MAS MR spectroscopy of intact tissue samples
| العنوان: | Metabolic portraits of breast cancer by HR MAS MR spectroscopy of intact tissue samples |
|---|---|
| المؤلفون: | Tone Frost Bathen, Leslie R. Euceda, Tonje Husby Haukaas, Guro F. Giskeødegård |
| المصدر: | Metabolites Metabolites, Vol 7, Iss 2, p 18 (2017) 2:18 |
| بيانات النشر: | MDPI AG, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, In vivo magnetic resonance spectroscopy, Pathology, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, lcsh:QR1-502, HR MAS MR spectroscopy, Translational research, Review, amino acid metabolism, Biology, Biochemistry, lcsh:Microbiology, 03 medical and health sciences, breast cancer, 0302 clinical medicine, Metabolomics, Breast cancer, medicine, Molecular Biology, medicine.diagnostic_test, Magnetic resonance imaging, glycolysis, medicine.disease, 030104 developmental biology, choline phospholipids, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Reprogramming, Ex vivo |
| الوصف: | Despite progress in early detection and therapeutic strategies, breast cancer remains the second leading cause of cancer-related death among women globally. Due to the heterogeneity and complexity of tumor biology, breast cancer patients with similar diagnosis might have different prognosis and response to treatment. Thus, deeper understanding of individual tumor properties is necessary. Cancer cells must be able to convert nutrients to biomass while maintaining energy production, which requires reprogramming of central metabolic processes in the cells. This phenomenon is increasingly recognized as a potential target for treatment, but also as a source for biomarkers that can be used for prognosis, risk stratification and therapy monitoring. Magnetic resonance (MR) metabolomics is a widely used approach in translational research, aiming to identify clinically relevant metabolic biomarkers or generate novel understanding of the molecular biology in tumors. Ex vivo proton high-resolution magic angle spinning (HR MAS) MR spectroscopy is widely used to study central metabolic processes in a non-destructive manner. Here we review the current status for HR MAS MR spectroscopy findings in breast cancer in relation to glucose, amino acid and choline metabolism. © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0Test/). |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe8ecb4cd32faa1af2962add7f68d8cTest http://hdl.handle.net/11250/2500376Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ebe8ecb4cd32faa1af2962add7f68d8c |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |