Vitamin D metabolism and profiling in veterinary species
| العنوان: | Vitamin D metabolism and profiling in veterinary species |
|---|---|
| المؤلفون: | Natalie Z.M. Homer, Emma Hurst, Richard J. Mellanby |
| المصدر: | Hurst, E, Homer, N Z M & Mellanby, R 2020, ' Vitamin D metabolism and profiling in veterinary species ', Metabolites, vol. 10, no. 9 . https://doi.org/10.3390/metabo10090371Test Metabolites Metabolites, Vol 10, Iss 371, p 371 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Veterinary medicine, 040301 veterinary sciences, Endocrinology, Diabetes and Metabolism, Metabolite, lcsh:QR1-502, Single sample, vitamin D, Review, Biology, Biochemistry, lcsh:Microbiology, 0403 veterinary science, 03 medical and health sciences, chemistry.chemical_compound, Vitamin D+Metabolites, free vitamin D, Liquid chromatography–mass spectrometry, Lc ms ms, Vitamin D and neurology, C3-epimers, LC-MS/MS, Molecular Biology, Vitamin D metabolism, comparative, 04 agricultural and veterinary sciences, veterinary, Clinical Practice, 030104 developmental biology, 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, chemistry, 24,25-dihydroxyvitamin-D, profiling |
| الوصف: | The demand for vitamin D analysis in veterinary species is increasing with the growing knowledge of the extra-skeletal role vitamin D plays in health and disease. The circulating 25-hydroxyvitamin-D (25(OH)D) metabolite is used to assess vitamin D status, and the benefits of analysing other metabolites in the complex vitamin D pathway are being discovered in humans. Profiling of the vitamin D pathway by liquid chromatography tandem mass spectrometry (LC-MS/MS) facilitates simultaneous analysis of multiple metabolites in a single sample and over wide dynamic ranges, and this method is now considered the gold-standard for quantifying vitamin D metabolites. However, very few studies report using LC-MS/MS for the analysis of vitamin D metabolites in veterinary species. Given the complexity of the vitamin D pathway and the similarities in the roles of vitamin D in health and disease between humans and companion animals, there is a clear need to establish a comprehensive, reliable method for veterinary analysis that is comparable to that used in human clinical practice. In this review, we highlight the differences in vitamin D metabolism between veterinary species and the benefits of measuring vitamin D metabolites beyond 25(OH)D. Finally, we discuss the analytical challenges in profiling vitamin D in veterinary species with a focus on LC-MS/MS methods. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c337bca8e3ac0a00f14a6578eda26939Test https://hdl.handle.net/20.500.11820/19b03e5b-5f11-4510-bd66-e67f4279b648Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c337bca8e3ac0a00f14a6578eda26939 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |