Development of an Aerobic Glycolysis Index for Predicting the Sorafenib Sensitivity and Prognosis of Hepatocellular Carcinoma

التفاصيل البيبلوغرافية
العنوان: Development of an Aerobic Glycolysis Index for Predicting the Sorafenib Sensitivity and Prognosis of Hepatocellular Carcinoma
المؤلفون: Yu Pan, Geng-yuan Hu, Shi Jiang, Shun-jie Xia, Hendi Maher, Zhong-jie Lin, Qi-jiang Mao, Jie Zhao, Liu-xin Cai, Ying-hua Xu, Jun-jie Xu, Xiu-jun Cai
المصدر: Frontiers in Oncology
Frontiers in Oncology, Vol 11 (2021)
سنة النشر: 2020
مصطلحات موضوعية: Sorafenib, Cancer Research, Poor prognosis, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, medicine.disease_cause, Treatment efficacy, Metabolic pathway, Oncology, Anaerobic glycolysis, Hepatocellular carcinoma, hepatocellar carcinoma, Cancer research, medicine, Biomarker (medicine), biomarker, prognosis, business, Carcinogenesis, aerobic glycolysis, RC254-282, medicine.drug, Original Research
الوصف: Hepatocellular carcinoma (HCC) is a deadly tumor with high heterogeneity. Aerobic glycolysis is a common indicator of tumor growth and plays a key role in tumorigenesis. Heterogeneity in distinct metabolic pathways can be used to stratify HCC into clinically relevant subgroups, but these have not yet been well-established. In this study, we constructed a model called aerobic glycolysis index (AGI) as a marker of aerobic glycolysis using genomic data of hepatocellular carcinoma from The Cancer Genome Atlas (TCGA) project. Our results showed that this parameter inferred enhanced aerobic glycolysis activity in tumor tissues. Furthermore, high AGI is associated with poor tumor differentiation and advanced stages and could predict poor prognosis including reduced overall survival and disease-free survival. More importantly, the AGI could accurately predict tumor sensitivity to Sorafenib therapy. Therefore, the AGI may be a promising biomarker that can accurately stratify patients and improve their treatment efficacy.
تدمد: 2234-943X
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472c7f488aa36dcece0279938463c0baTest
https://pubmed.ncbi.nlm.nih.gov/34094917Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....472c7f488aa36dcece0279938463c0ba
قاعدة البيانات: OpenAIRE