دورية أكاديمية
Apolipoprotein M and Risk of Type 2 Diabetes
| العنوان: | Apolipoprotein M and Risk of Type 2 Diabetes |
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| المؤلفون: | Hajny, Stefan, Christoffersen, Mette, Dalila, Nawar, Nielsen, Lars B., Tybjærg-Hansen, Anne, Christoffersen, Christina |
| المصدر: | Hajny , S , Christoffersen , M , Dalila , N , Nielsen , L B , Tybjærg-Hansen , A & Christoffersen , C 2020 , ' Apolipoprotein M and Risk of Type 2 Diabetes ' , Journal of Clinical Endocrinology and Metabolism , vol. 105 , no. 9 , pp. 3046-3057 . https://doi.org/10.1210/clinem/dgaa433Test |
| سنة النشر: | 2020 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | Apolipoproteins, Genetics, Mendelian randomization, Type 2 diabetes |
| الوصف: | Context: Recent studies have discovered a role of apolipoprotein M (apoM) in energy metabolism, and observational analyses in humans suggest an association with type 2 diabetes. The causal relationship remains however elusive. Objective: To investigate whether reduced plasma apoM concentrations are causally linked to increased risk of type 2 diabetes. Design: Prospective study design analyzed by Mendelian randomization. Setting and participants: Two cohorts reflecting the Danish general population: the Copenhagen City Heart Study (CCHS, n = 8589) and the Copenhagen General Population Study (CGPS; n = 93 857). Observational analyses included a subset of participants from the CCHS with available plasma apoM (n = 725). Genetic analyses included the complete cohorts (n = 102 446). During a median follow-up of 16 years (CCHS) and 8 years (CGPS), 563 and 2132 participants developed type 2 diabetes. Main outcome measures: Plasma apoM concentration, genetic variants in APOM, and type 2 diabetes. Results: First, we identified an inverse correlation between plasma apoM and risk of type 2 diabetes in a subset of participants from the CCHS (hazard ratio between highest vs lowest quartile (reference) = 0.32; 95% confidence interval = 0.1-1.01; P for trend = .02). Second, genotyping of specific single nucleotide polymorphisms in APOM further revealed a 10.8% (P = 6.2 × 10 –5 ) reduced plasma apoM concentration in participants with variant rs1266078. Third, a meta-analysis including data from 599 451 individuals showed no association between rs1266078 and risk of type 2 diabetes. Conclusions: The present study does not appear to support a causal association between plasma apoM and risk of type 2 diabetes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1210/clinem/dgaa433 |
| الإتاحة: | https://doi.org/10.1210/clinem/dgaa433Test https://pure.au.dk/portal/da/publications/apolipoprotein-m-and-risk-of-type-2-diabetesTest(455b6f35-60bc-4f3f-98f9-8da6580dac43).html http://www.scopus.com/inward/record.url?scp=85089128391&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.369B156D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1210/clinem/dgaa433 |
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