التفاصيل البيبلوغرافية
| العنوان: |
Managing Metastatic Melanoma in 2022: A Clinical Review. |
| المؤلفون: |
Switzer, Benjamin, Puzanov, Igor, Skitzki, Joseph J., Hamad, Lamya, Ernstoff, Marc S. |
| المصدر: |
JCO Oncology Practice; May2022, Vol. 18 Issue 5, p335-352, 18p |
| مصطلحات موضوعية: |
MELANOMA prognosis, PUBLIC health surveillance, CYTOKINES, MELANOMA, METASTASIS, TREATMENT effectiveness, HUMAN microbiota, DECISION making in clinical medicine, IMMUNOTHERAPY, DISEASE risk factors |
| مصطلحات جغرافية: |
UNITED States |
| مستخلص: |
Cutaneous melanoma remains the most lethal of the primary cutaneous neoplasms, and although the incidence of primary melanoma continues to rise, the mortality from metastatic disease remains unchanged, in part through advances in treatment. Major developments in immunomodulatory and targeted therapies have provided robust improvements in response and survival trends that have transformed the clinical management of patients with metastatic melanoma. Additional advances in immunologic and cancer cell biology have contributed to further optimization in (1) risk stratification, (2) prognostication, (3) treatment, (4) toxicity management, and (5) surveillance approaches for patients with an advanced melanoma diagnosis. In this review, we provide a comprehensive overview of the historical and future advances regarding the translational and clinical implications of advanced melanoma and share multidisciplinary recommendations to aid clinicians in the navigation of current treatment approaches for a variety of patient cohorts. [ABSTRACT FROM AUTHOR] |
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Copyright of JCO Oncology Practice is the property of American Society of Clinical Oncology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
