المؤلفون: Sohier, Pierre, Legrand, Léa, Aktary, Zackie, Grill, Christine, Delmas, Véronique, Bernex, Florence, Reyes-Gomez, Edouard, Larue, Lionel, Vergier, Béatrice

المصدر: Pigment Cell and Melanoma Research, 31 (3), 423 - 431 (2018-05)

مصطلحات موضوعية: histopathology, Ink4a, melanocyte, melanoma, melanoma model, Pten, Ras, transgenic mice, β-catenin, Amino Acid Substitution, Animals, Mice, Transgenic, Monomeric GTP-Binding Proteins, Mutation, Missense, Biochemistry, Genetics and Molecular Biology (all), Oncology, Dermatology, General Biochemistry, Genetics and Molecular Biology, Life sciences, biophysics & molecular biology, Sciences du vivant, Biochimie, biophysique & biologie moléculaire

الوصف: peer reviewed ; Genetically engineered mouse models offer essential opportunities to investigate the mechanisms of initiation and progression in melanoma. Here, we report a new simplified histopathology classification of mouse melanocytic lesions in Tyr::NRASQ 61K derived models, using an interactive decision tree that produces homogeneous categories. Reproducibility for this classification system was evaluated on a panel of representative cases of murine melanocytic lesions by pathologists and basic scientists. Reproducibility, measured as inter-rater agreement between evaluators using a modified Fleiss’ kappa statistic, revealed a very good agreement between observers. Should this new simplified classification be adopted, it would create a robust system of communication between researchers in the field of mouse melanoma models.

العلاقة: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fpcmr.12677Test; urn:issn:1755-1471; urn:issn:1755-148X; https://orbi.uliege.be/handle/2268/291202Test; info:hdl:2268/291202; https://orbi.uliege.be/bitstream/2268/291202/1/Pigment%20Cell%20Melanoma%20Res%20-%202017%20-%20Sohier%20-%20A%20histopathological%20classification%20system%20of%20Tyr%20%20NRASQ61K%20murine%20melanocytic.pdfTest; scopus-id:2-s2.0-85038850233; info:pmid:29224244

الإتاحة: https://doi.org/10.1111/pcmr.12677Test
https://orbi.uliege.be/handle/2268/291202Test
https://orbi.uliege.be/bitstream/2268/291202/1/Pigment%20Cell%20Melanoma%20Res%20-%202017%20-%20Sohier%20-%20A%20histopathological%20classification%20system%20of%20Tyr%20%20NRASQ61K%20murine%20melanocytic.pdfTest

المؤلفون: Sohier, Pierre^1,2,3, Legrand, Léa^4,5, Aktary, Zackie^1,2,3, Grill, Christine^1,2,3, Delmas, Véronique^1,2,3, Bernex, Florence⁶, Reyes‐Gomez, Edouard^7,8,9, Larue, Lionel^1,2,3 lionel.larue@curie.fr, Vergier, Béatrice^4,5

المصدر: Pigment Cell & Melanoma Research. May2018, Vol. 31 Issue 3, p423-431. 10p.

مصطلحات موضوعية: *SQUAMOUS cell carcinoma, *MELANOMA, *MELANOCYTES, *SKIN cancer, *BIOPSY

مستخلص: Summary: Genetically engineered mouse models offer essential opportunities to investigate the mechanisms of initiation and progression in melanoma. Here, we report a new simplified histopathology classification of mouse melanocytic lesions in Tyr::NRASQ61K derived models, using an interactive decision tree that produces homogeneous categories. Reproducibility for this classification system was evaluated on a panel of representative cases of murine melanocytic lesions by pathologists and basic scientists. Reproducibility, measured as inter‐rater agreement between evaluators using a modified Fleiss’ kappa statistic, revealed a very good agreement between observers. Should this new simplified classification be adopted, it would create a robust system of communication between researchers in the field of mouse melanoma models. [ABSTRACT FROM AUTHOR]