المؤلفون: Maria Antonietta Mazzei, Gabriele Lucii, Giulio Bagnacci, Valerio Nardone, Franco Roviello, Gian Luca Baiocchi, Letizia Di Giacomo, Paolo Tini, Paolo Morgagni, Frida Pittiani, Gianni Mura, Daniele Marrelli, Francesco Gentili, Luca Volterrani

المساهمون: Mazzei, M. A., Di Giacomo, L., Bagnacci, G., Nardone, V., Gentili, F., Lucii, G., Tini, P., Marrelli, D., Morgagni, P., Mura, G., Baiocchi, G. L., Pittiani, F., Volterrani, L., Roviello, F.

المصدر: Quant Imaging Med Surg

مصطلحات موضوعية: medicine.medical_specialty, medicine.medical_treatment, Stomach neoplasms, Population, Logistic regression, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine, Radiology, Nuclear Medicine and imaging, education, Neoadjuvant therapy, Tumor Regression Grade, education.field_of_study, Receiver operating characteristic, business.industry, Cancer, Retrospective cohort study, medicine.disease, 030220 oncology & carcinogenesis, Cohort, Original Article, Radiology, business, Multidetector computed tomography (MDCT)

الوصف: BACKGROUND: To predict response to neoadjuvant chemotherapy (NAC) of gastric cancer (GC), prior to surgery, would be pivotal to customize patient treatment. The aim of this study is to investigate the reliability of computed tomography (CT) texture analysis (TA) in predicting the histo-pathological response to NAC in patients with resectable locally advanced gastric cancer (AGC). METHODS: Seventy (40 male, mean age 63.3 years) patients with resectable locally AGC, treated with NAC and radical surgery, were included in this retrospective study from 5 centers of the Italian Research Group for Gastric Cancer (GIRCG). Population was divided into two groups: 29 patients from one center (internal cohort for model development and internal validation) and 41 from other four centers (external cohort for independent external validation). Gross tumor volume (GTV) was segmented on each pre- and post-NAC multidetector CT (MDCT) image by using a dedicated software (RayStation), and 14 TA parameters were then extrapolated. Correlation between TA parameters and complete pathological response (tumor regression grade, TRG1), was initially investigated for the internal cohort. The univariate significant variables were tested on the external cohort and multivariate logistic analysis was performed. RESULTS: In multivariate logistic regression the only significant TA variable was delta gray-level co-occurrence matrix (GLCM) contrast (P=0.001, Nagelkerke R(2): 0.546 for the internal cohort and P=0.014, Nagelkerke R(2): 0.435 for the external cohort). Receiver operating characteristic (ROC) curves, generated from the logistic regression of all the patients, showed an area under the curve (AUC) of 0.763. CONCLUSIONS: Post-NAC GLCM contrast and dissimilarity and delta GLCM contrast TA parameters seem to be reliable for identifying patients with locally AGC responder to NAC.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3626ed4c77f2d018c0b73eacd30b1baTest
https://doi.org/10.21037/qims-20-683Test

المؤلفون: Evan W Nardone, Michael P. Savage, Paul Walinsky, Nicholas J. Ruggiero, David L. Fischman, Melissa McCarey, Brandon M Madsen, Alec Vishnevsky

المصدر: World Journal of Cardiology

مصطلحات موضوعية: medicine.medical_specialty, Acute coronary syndrome, Coronary stents, Restenosis, business.industry, medicine.medical_treatment, Saphenous vein grafts, Coronary artery bypass grafting, Percutaneous coronary intervention, Stent, medicine.disease, Angina, Chronic total occlusion, Bypass surgery, Retrospective Study, Internal medicine, Conventional PCI, medicine, Cardiology, cardiovascular diseases, Myocardial infarction, Cardiology and Cardiovascular Medicine, business, Mace

الوصف: BACKGROUND Percutaneous coronary intervention (PCI) of diseased saphenous vein grafts (SVG) continues to pose a clinical challenge. Current PCI guidelines give a class III recommendation against performing PCI on chronically occluded SVG. However, contemporary outcomes after SVG intervention have incrementally improved with distal protection devices, intracoronary vasodilators, drug-eluting stents, and prolonged dual antiplatelet therapy. AIM To reassess the procedural and long-term outcomes of PCI for totally occluded SVG with contemporary techniques. METHODS This was a retrospective observational study conducted at a single university hospital. The study population consisted of 35 consecutive patients undergoing PCI of totally occluded SVG. Post-procedure dual antiplatelet therapy was continued for a minimum of one year and aspirin was continued indefinitely. Clinical outcomes were assessed at a mean follow-up of 1221 ± 1038 d. The primary outcome was freedom from a major adverse cardiac event (MACE) defined as the occurrence of any of the following: death, myocardial infarction, stroke, repeat bypass surgery, repeat PCI, or graft reocclusion. RESULTS The study group included 29 men and 6 women with a mean age of 69 ± 12 years. Diabetes was present in 14 (40%) patients. All patients had Canadian Heart Classification class III or IV angina. Clinical presentation was an acute coronary syndrome in 34 (97%) patients. Mean SVG age was 12 ± 5 years. Estimated duration of occlusion was acute (< 24 h) in 34% of patients, subacute (> 24 h to 30 d) in 26%, and late (> 30 d) in 40%. PCI was initially successful in 29/35 SVG occlusions (83%). Total stent length was 52 ± 35 mm. Intraprocedural complications of distal embolization or no-reflow occurred in 6 (17%) patients. During longer term follow-up, MACE-free survival was only 30% at 3 years and 17% at 5 years. CONCLUSION PCI of totally occluded SVG can be performed with a high procedural success rate. However, its clinical utility remains limited by poor follow-up outcomes.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d84447e415be1837c8d127c313e2e6Test
https://doi.org/10.4330/wjc.v13.i9.493Test

المؤلفون: Bruno Beomonte Zobel, Antonella Bianchi, Marco Parillo, Carlo Cosimo Quattrocchi, Carlo De Cicco Nardone, Carlo Altomare

المصدر: Journal of Endometriosis and Pelvic Pain Disorders. 13:262-265

مصطلحات موضوعية: medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Endometriosis, Computed tomography, medicine.disease, medicine.anatomical_structure, Laparotomy, Rare case, Medicine, Implant, Radiology, Canal of Nuck, business, Surgical treatment

الوصف: Introduction: Endometriosis is a common and chronic gynaecological condition but the implant in the canal of Nuck constitutes a very unusual state with an estimated prevalence of 0.3%–0.6% of all endometriosis cases. The canal of Nuck is an abnormal patent pouch of parietal peritoneum extending anteriorly from the round ligament of the uterus into the labia majora, thus represents a communication between the peritoneal cavity and the female inguinal canal. This condition may permit the seeding of endometriotic tissue in the inguinal soft tissues, becoming a possible cause of inguinal swelling or pain. Case description: A 43-years-old woman presented with painful swelling in her left groin. Ultrasound and a subsequent pelvic computed tomography showed a cystic lesion as for a Nuck’s canal encysted hydrocele. The patient underwent an anterior open surgery and the histologic examination revealed an endometrium-like tissue in the cystic wall. Conclusion: In women presenting with painful swelling of the groin, despite its rarity, endometriosis of the Nuck’s canal must be differentiated from other more common pathologies like hernias, varicoceles, neoplasms, and lymphadenopathies. Imaging can aid in differential diagnosis, but the final diagnosis is entrusted to histology, which enable to exclude an underlying malignancy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::11c8cbbed15eac1343116103cc90a9bbTest
https://doi.org/10.1177/22840265211037235Test

المؤلفون: Cristian Toraci, Jessica Imbrescia, Andrea Emanuele Guerini, Alessandro Magli, Salvatore Cappabianca, Luigi Spiazzi, Silvia Lucchini, Giulia Volpi, Alfonso Reginelli, Valerio Nardone, Paolo Borghetti, Stefano Maria Magrini

المساهمون: Borghetti, P., Toraci, C., Imbrescia, J., Volpi, G., Lucchini, S., Guerini, A. E., Magli, A., Spiazzi, L., Reginelli, A., Cappabianca, S., Magrini, S. M., Nardone, V.

المصدر: Annals of Nuclear Medicine. 35:1174-1176

مصطلحات موضوعية: Oncology, medicine.medical_specialty, 2019-20 coronavirus outbreak, Single Photon Emission Computed Tomography Computed Tomography, Lung Neoplasms, Coronavirus disease 2019 (COVID-19), SARS-CoV-2, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), medicine.medical_treatment, MEDLINE, COVID-19, General Medicine, medicine.disease, Radiation therapy, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, Lung cancer, business, Human

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9346920b7b205659f97e95887898481aTest
https://doi.org/10.1007/s12149-021-01662-zTest

المؤلفون: Chappell, E., Kohns Vasconcelos, M., Goodall, R. L., Galli, L., Goetghebuer, T., Noguera-Julian, A., Rodrigues, L. C., Scherpbier, H., Smit, C., Bamford, A., Crichton, S., Navarro, M. L., Ramos, J. T., Warszawski, J., Spolou, V., Chiappini, E., Venturini, E., Prata, F., Kahlert, C., Marczynska, M., Marques, L., Naver, L., Thorne, C., Gibb, D. M., Giaquinto, C., Judd, A., Collins, I. J., Goodall, R., Rodrigues, L., Duff, C., Gomezpena, D., Jackson, C., Lundin, R., Mangiarini, L., Milanzi, E., Nardone, A., Hainaut, M., Van der Kelen, E., Delforge, M., Le Chenadec, J., Ramos, E., Dialla, O., Wack, T., Laurent, C., Ait si Selmi, L., Leymarie, I., Ait Benali, F., Brossard, M., Boufassa, L., Floch-Tudal, C., Firtion, G., Hau, I., Chace, A., Bolot, P., Blanche, S., Granier, M., Labrune, P., Lachassine, E., Dollfus, C., Levine, M., Fourcade, C., Heller-Roussin, B., Runel-Belliard, C., Tricoire, J., Monpoux, F., Chirouze, C., Reliquet, V., Brouard, J., Kebaili, K., Fialaire, P., de Villeneuve, A., Lalande, M., de Flandres, J., Mazingue, F., Partisani, M. L., de Martino, M., Angelo Tovo, P., Gabiano, C., Carloni, I., Larovere, D., Baldi, F., Miniaci, A., Pession, A., Badolato, R., Panto, G., Anastasio, E., Montagnani, C., Bianchi, L., Allodi, A., Di Biagio, A., Grignolo, S., Giacomet, V., Marchisio, P., Banderali, G., Tagliabue, C., Cellini, M., Bruzzese, E., Di Costanzo, P., Lo Vecchio, A., Dona, D., Rampon, O., Romano, A., Dodi, I., Esposito, S., Zuccaro, V., Zanaboni, D., Consolini, R., Bernardi, S., Genovese, O., Cristiano, L., Mazza, A., Garazzino, S., Mignone, F., Silvestro, E., Portelli, V., Kinderziekenhuis, E., van der Kuip, M., Pajkrt, D., Scherpbier, H. J., de Boer, C., Weijsenfeld, A. M., Jurriaans, S., Back, N. K. T., Zaaijer, H. L., Berkhout, B., Cornelissen, M. T. E., Schinkel, C. J., Wolthers, K. C., Fraaij, P. L. A., van Rossum, A. M. C., Vermont, C. L., van der Knaap, L. C., Visser, E., Boucher, C. A. B., Koopmans, M. P. G., van Kampen, J. J. A., Henriet, S. S. V., van Aerde, M. K., Strik-Albers, R., Rahamat-Langendoen, J., Stelma, F. F., Burger, D., Scholvinck, E. H., de Groot-de Jonge, H., Niesters, H. G. M., van Leer-Buter, C. C., Knoester, M., Bont, L. J., Geelen, S. P. M., Loeffen, Y. G. T., Wolfs, T. F. W., Nauta, N., Schuurman, R., Hofstra, L. M., Wensing, A. M. J., Reiss, P., Zaheri, S., Boyd, A. C., Bezemer, D. O., van Sighem, A. I., Wit, F. W. M. N., Hillebregt, M. M. J., Woudstra, T. J., Bergsma, D., van de Sande, L., Rutkens, T., van der Vliet, S., Lelivelt, K. J., Scheijgrond, A., de Groot, L., van den Akker, M., Bakker, Y., EI Berkaoui, A., Bezemer, M., Bretin, N., Djoechro, E., Groters, M., Kruijne, E., Lodewijk, C., Lucas, E., Munjishvili, L., Paling, F., Peeck, B., Ree, C., Regtop, R., Ruijs, Y., Schoorl, M., Schnorr, P., Tuijn, E., Veenenberg, L., Visser, K. M., Witte, E. C., Popielska, J., Pokorska-Spiewak, M., Oldakowska, A., Zawadka, K., Coupland, U., Doroba, M., Teixeira, C., Fernandes, A., Soler-Palacin, P., Antoinette Frick, M., Perez-Hoyos, S., Mur, A., Lopez, N., Mendez, M., Mayol, L., Vallmanya, T., Calavia, O., Garcia, L., Coll, M., Pineda, V., Rius, N., Rovira, N., Duenas, J., Fortuny, C., Jose Mellado, M., Escosa, L., Garcia Hortelano, M., Sainz, T., Gonzalez-Tome, M. I., Rojo, P., Blazquez, D., Prieto-Tato, L., Epalza, C., Tomas Ramos, J., Guillen, S., Saavedra, J., Santos, M., Santiago, B., de Ory, S. J., Carrasco, I., Munoz-Fernandez, M. A., Angel Roa, M., Penin, M., Martinez, J., Badillo, K., Onate, E., Pocheville, I., Garrote, E., Colino, E., Gomez Sirvent, J., Garzon, M., Roman, V., Angulo, R., Neth, O., Falcon, L., Terol, P., Luis Santos, J., Moreno, D., Lendinez, F., Peromingo, E., Uberos, J., Ruiz, B., Grande, A., Jose Romero, F., Perez, C., Lillo, M., Losada, B., Herranz, M., Bustillo, M., Collado, P., Antonio Couceiro, J., Vila, L., Calvino, C., Isabel Piqueras, A., Oltra, M., Gavilan, C., Montesinos, E., Dapena, M., Alvarez, C., Jimenez, B., Gloria Andres, A., Marugan, V., Ochoa, C., Alfayate, S., Isabel Menasalvas, A., del Prado, Y. R., Navernaver, L., Soeria-Atmadja, S., Belfrage, E., Hagas, V., Aebi-Popp, K., Anagnostopoulos, A., Battegay, M., Baumann, M., Bernasconi, E., Boni, J., Braun, D. L., Bucher, H. C., Calmy, A., Cavassini, M., Ciuffi, A., Crisinel, P. A., Duppenthaler, A., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Francini, K., Furrer, H., Fux, C. A., Gunthard, H. F., Haerry, D., Hasse, B., Hirsch, H. H., Hoffmann, M., Hosli, I., Huber, M., Kaiser, L., Keiser, O., Klimkait, T., Kottanattu, L., Kouyos, R. D., Kovari, H., Ledergerber, B., Martinetti, G., Martinez de Tejada, B., Marzolini, C., Metzner, K. J., Muller, N., Nicca, D., Paioni, P., Pantaleo, G., Perreau, M., Polli, C., Rauch, A., Rudin, C., Scherrer, A. U., Schmid, P., Speck, R., Stockle, M., Sultan-Beyer, L., Tarr, P., Thanh Lecompte, M., Trkola, A., Vernazza, P., Wagner, N., Wandeler, G., Weber, R., Yerly, S., Lyall, H., Butler, K., Doerholt, K., Doherty, C., Foster, C., Harrison, I., Kenny, J., Klein, N., Letting, G., Mcmaster, P., Murau, F., Nsangi, E., Prime, K., Riordan, A., Shackley, F., Shingadia, D., Storey, S., Tudor-Williams, G., Turkova, A., Welch, S., Cook, C., Dobson, D., Fairbrother, K., Prevost, M. L., Van Looy, N., Peters, H., Francis, K., Thrasyvoulou, L., Fidler, K., Bernatoniene, J., Manyika, F., Sharpe, G., Subramaniam, B., Hague, R., Price, V., Flynn, J., Cardoso, A., Abou - Rayyah, M., Yeadon, S., Segal, S., Hawkins, S., Dowie, M., Bandi, S., Percival, E., Eisenhut, M., Duncan, K., Anguvaa, L., Wren, L., Flood, T., Pickering, A., Murphy, C., Daniels, J., Lees, Y., Thompson, F., Williams, A., Williams, B., Pope, S., Libeschutz, S., Cliffe, L., Southall, S., Freeman, A., Freeman, H., Christie, S., Gordon, A., Rosie Hague, D., Clarke, L., Jones, L., Brown, L., Greenberg, M., Benson, C., Ibberson, L., Patel, S., Hancock, J., Sharland, M., Lyall, E. G. H., Seery, P., Kirkhope, N., Raghunanan, S., Callaghan, A., Bridgwood, A., Evans, J., Blake, E., Yannoulias, A.

المساهمون: Department of Sciences for Woman and Child's Health, Florence University, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Paediatric Infectious Diseases / Rheumatology / Immunology, Amsterdam institute for Infection and Immunity, Infectious diseases, AII - Infectious diseases, Amsterdam Reproduction & Development (AR&D), Medical Microbiology and Infection Prevention, Gastroenterology and Hepatology, Global Health, APH - Aging & Later Life, Biomedical Engineering and Physics, ACS - Atherosclerosis & ischemic syndromes, 1, Elizabeth Chappell, 2 3 4, Malte Kohns Vasconcelo, L Goodall 1, Ruth, 5, Luisa Galli, 6, Tessa Goetghebuer, 9 10, Antoni Noguera-Julian 7 8, C Rodrigues 2, Laura, Scherpbier 11, Henriette, Smit 12, Colette, 1 13 14, Alasdair Bamford, 1, Siobhan Crichton, Luisa Navarro 10 15 16 17, Marissa, T Ramos 18, Jose, Warszawski 19 20, Josiane, Spolou 21, Vana, 5, Elena Chiappini, 5, Elisabetta Venturini, Prata 22, Filipa, Kahlert 23, Christian, Marczynska 24, Magdalena, Marques 25, Laura, Naver 26, Lar, Thorne 14, Claire, M Gibb 1, Diana, Giaquinto 27, Carlo, 1, Ali Judd, 1, Intira Jeannie Collin, Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC), European, Goodall, Ruth, Rodrigues, Laura, Duff, Charlotte, Gomezpena, Daniel, Jackson, Charlotte, Lundin, Rebecca, Mangiarini, Laura, Milanzi, Edith, Nardone, Alessandra, Hainaut, Marc, Van der Kelen, Evelyne, Delforge, Marc, Le Chenadec, Jerome, Ramos, Elisa, Dialla, Olivia, Wack, Thierry, Laurent, Corine, Ait Si Selmi, Lamya, Leymarie, Isabelle, Ait Benali, Fazia, Brossard, Maud, Boufassa, Leila, Floch-Tudal, Corinne, Firtion, Ghislaine, Hau, Isabelle, Chace, Anne, Bolot, Pascal, Blanche, Stéphane, Granier, Michèle, Labrune, Philippe, Lachassine, Eric, Dollfus, Catherine, Levine, Martine, Fourcade, Corinne, Heller-Roussin, Brigitte, Runel-Belliard, Camille, Tricoire, Joëlle, Monpoux, Fabrice, Chirouze, Catherine, Reliquet, Véronique, Brouard, Jacque, Kebaili, Kamila, Fialaire, Pascale, de Villeneuve, Arnaud, Lalande, Muriel, de Flandres, Jeanne, Mazingue, Françoise, Luisa Partisani, Maria, de Martino, Maurizio, Angelo Tovo, Pier, Gabiano, Clara, Carloni, Ine, Larovere, Domenico, Baldi, Francesco, Miniaci, Angela, Pession, Andrea, Badolato, Raffaele, Pantò, Grazia, Anastasio, Elisa, Montagnani, Carlotta, Bianchi, Leila, Allodi, Alessandra, Di Biagio, Antonio, Grignolo, Sara, Giacomet, Vania, Marchisio, Paola, Banderali, Giuseppe, Tagliabue, Claudia, Cellini, Monica, Bruzzese, Eugenia, DI COSTANZO, Pasquale, LO VECCHIO, Andrea, Donà, Daniele, Rampon, Osvalda, Romano, Amelia, Dodi, Icilio, Esposito, Susanna, Zuccaro, Valentina, Zanaboni, Domenico, Consolini, Rita, Bernardi, Stefania, Genovese, Orazio, Cristiano, Letizia, Mazza, Antonio, Garazzino, Silvia, Mignone, Federica, Silvestro, Erika, Portelli, Vincenzo, Pediatric surgery, Pediatrics, Virology

المصدر: HIV Medicine
HIV Medicine, Wiley, 2021, ⟨10.1111/hiv.13177⟩
HIV medicine. Wiley-Blackwell
Hiv Medicine, 23, 2, pp. 186-196
Hiv Medicine, 23, 186-196
van der Kuip, M 2021, ' Children living with HIV in Europe: do migrants have worse treatment outcomes? ', HIV Medicine . https://doi.org/10.1111/hiv.13177Test
HIV MEDICINE
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
HIV Medicine, 23(2), 186-196. Wiley-Blackwell Publishing Ltd

مصطلحات موضوعية: children, Europe, HIV, migrant, mortality, Adolescent, Child, Humans, Treatment Outcome, Viral Load, Anti-HIV Agents, HIV Infections, Transients and Migrants, medicine.medical_treatment, Human immunodeficiency virus (HIV), lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], medicine.disease_cause, 0302 clinical medicine, Medicine, Pharmacology (medical), 030212 general & internal medicine, health care economics and organizations, Health Policy, Hazard ratio, virus diseases, Immunosuppression, Infectious Diseases, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, population characteristics, 0305 other medical science, Viral load, geographic locations, education, 03 medical and health sciences, Acquired immunodeficiency syndrome (AIDS), SDG 3 - Good Health and Well-being, 030505 public health, business.industry, Proportional hazards model, medicine.disease, Confidence interval, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Observational study, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Demography

الوصف: Contains fulltext : 249078.pdf (Publisher’s version ) (Open Access) OBJECTIVES: To assess the effect of migrant status on treatment outcomes among children living with HIV in Europe. METHODS: Children aged

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95d753ffd01848240447cbb0ec01dddTest
http://hdl.handle.net/2318/1870163Test

المؤلفون: Alba Fiorentino, Valerio Nardone, Carlo Greco, V. Salvestrini, Fabiana Gregucci, Giuseppe Carlo Iorio, Paolo Borghetti, F. De Felice, Isacco Desideri

المساهمون: Salvestrini, V., Iorio, G. C., Borghetti, P., De Felice, F., Greco, C., Nardone, V., Fiorentino, A., Gregucci, F., Desideri, I.

مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, radiotherapy planning, Time Factors, Heart Diseases, Side effect, Intensity-modulated radiotherapy, medicine.medical_treatment, Breast Neoplasms, breast cancer, cardiac toxicity, deep inspiration breath hold, intensity-modulated radiotherapy, late effects, late sequelae, modern RT, secondary cancer, breast neoplasms, breath holding, female, heart diseases, humans, inhalation, radiation injuries, radiotherapy planning, computer-assisted, time factors, cancer survivors, radiotherapy, Breath Holding, Breast cancer, Cancer Survivors, Cardiac toxicity, medicine, Humans, Radiation Injuries, Intensive care medicine, Deep inspiration breath-hold, Radiotherapy, Deep inspiration breath hold, Treatment choices, business.industry, Radiotherapy Planning, Computer-Assisted, General Medicine, Limiting, medicine.disease, Radiation therapy, Inhalation, Oncology, Late effect, computer-assisted, Modern RT, Life expectancy, Female, Secondary cancer, business, Late sequelae

الوصف: Introduction: One of the most feared side effects of radiotherapy (RT) in the setting of breast cancer (BC) patients is cardiac toxicity. This side effect can jeopardize the quality of life (QoL) of long-term survivors. The impact of modern techniques of RT such as deep inspiration breath hold (DIBH) have dramatically changed this setting. We report and discuss the results of the literature overview of this paper. Materials and methods: Literature references were obtained with a PubMed query, hand searching, and clinicaltrials.gov. Results: We reported and discussed the toxicity of RT and the improvements due to the modern techniques in the setting of BC patients. Conclusions: BC patients often have a long life expectancy, thus the RT should aim at limiting toxicities and at the same time maintaining the same high cure rates. Further studies are needed to evaluate the risk–benefit ratio to identify patients at higher risk and to tailor the treatment choices.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde7a74d7a512c72873bdfdc88f54bf2Test
https://hdl.handle.net/11591/483768Test

المؤلفون: Domenico Azzarello, Antonio Nesci, Valerio Nardone, Pierfrancesco Tassone, Diana Giannarelli, Amalia Luce, Luciano Mutti, Irene Di Meo, Alfonso Reginelli, Rocco Giannicola, Rita Emilena Saladino, Luigi Pirtoli, Daniele Caracciolo, Vito Barbieri, Maria Rosaria Rizzo, Pierosandro Tagliaferri, P. Correale, Pierpaolo Pastina, Giovanna Bianco, Caterina Romeo, Michele Caraglia, Salvatore Cappabianca, Antonio Giordano, Antonia Consuelo Falzea

المساهمون: Nardone, V., Giannicola, R., Giannarelli, D., Saladino, R. E., Azzarello, D., Romeo, C., Bianco, G., Rizzo, M. R., Di Meo, I., Nesci, A., Pastina, P., Falzea, A. C., Caracciolo, D., Reginelli, A., Caraglia, M., Luce, A., Mutti, L., Giordano, A., Cappabianca, S., Pirtoli, L., Barbieri, V., Tassone, P., Tagliaferri, P., Correale, P.

المصدر: Life
Volume 11
Issue 11
Life, Vol 11, Iss 1235, p 1235 (2021)

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Science, medicine.medical_treatment, Inflammation, Systemic inflammation, General Biochemistry, Genetics and Molecular Biology, Article, real-world evidence study, Atezolizumab, Internal medicine, medicine, Lung cancer, Ecology, Evolution, Behavior and Systematics, immunosenescence, business.industry, metastatic non-small-cell lung cancer, Paleontology, Immunotherapy, Immunosenescence, immune checkpoint blockade, medicine.disease, inflammatory markers, Immune checkpoint, age, Space and Planetary Science, Inflammatory marker, immunotherapy, Nivolumab, medicine.symptom, business

الوصف: An immune checkpoint blockade with mAbs to PD-1 and PD-L1 is an expanding therapeutic option for mNSCLC patients. This treatment strategy is based on the use of mAbs able to restore the anti-tumor activity of intratumoral T cells inhibited by PD-1 binding to PD-L1/2 on tumor and inflammatory cells. It has been speculated that a chronic status of systemic inflammation as well as the immunosenescence physiologically occurring in elderly patients may affect the efficacy of the treatment and the occurrence of irAEs. We performed a multi-institutional retrospective study aimed at evaluating the effects of these mAbs (nivolumab or atezolizumab) in 117 mNSCLC patients younger (90 cases) and older (27 cases) than 75 years in correlation with multiple inflammatory parameters (NLR, CRP, ESR, LDH and PCT). No differences were observed when the cohorts were compared in terms of the frequency of PFS, OS, inflammatory markers and immune-related adverse events (irAEs). Similarly, the occurrence of irAEs was strictly correlated with a prolonged OS survival in both groups. On the contrary, a negative correlation between the high baseline levels of inflammatory markers and OS could be demonstrated in the younger cohort only. Overall, PD-1/PD-L1-blocking mAbs were equally effective in young and elderly mNSCLC patients
however, the detrimental influence of a systemic inflammation at the baseline was only observed in young patients, suggesting different aging-related inflammation immunoregulative effects.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b90d15be9d66293659e0c07af4932c1Test
http://europepmc.org/articles/PMC8621400Test

المؤلفون: Raffaele Nardone, Leopold Saltuari, Viviana Versace, Eugen Trinka, Luca Sebastianelli, Francesco Brigo, Stefan Golaszewski, Paolo Manganotti

المساهمون: Nardone, Raffaele, Sebastianelli, Luca, Versace, Viviana, Brigo, Francesco, Golaszewski, Stefan, Manganotti, Paolo, Saltuari, Leopold, Trinka, Eugen

المصدر: Brain Research Bulletin. 159:44-52

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, disorders of consciousne, Traumatic brain injury, medicine.medical_treatment, Disorders of consciousness, auditory dysfunction, behavioral disciplines and activities, Neuroprotection, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Brain Injuries, Traumatic, medicine, Animals, Humans, Cognitive Dysfunction, disorders of consciousness, Depression (differential diagnoses), Neurorehabilitation, Depression, business.industry, traumatic brain injury, General Neuroscience, repetitive transcranial magnetic stimulation, Cognition, medicine.disease, Transcranial Magnetic Stimulation, Transcranial magnetic stimulation, Disease Models, Animal, 030104 developmental biology, nervous system, cognitive disturbances, cognitive disturbance, depression, Consciousness Disorders, medicine.symptom, business, 030217 neurology & neurosurgery, Tinnitus

الوصف: We provide here the first systematic review on the studies dealing with repetitive transcranial magnetic stimulation (rTMS) for traumatic brain injury (TBI) in animals and humans. Several experimental studies in animal models have explored with promising results the use of rTMS to enhance neuroprotection and recovery after TBI. However, there are surprisingly few studies that have obtained substantial evidence regarding effects of rTMS in humans with TBI, many of them are case reports investigating the heterogeneous conditions linked to TBI. The most studies have investigated the effects of rTMS in subjects with post-traumatic depression and variable effects have been observed. rTMS has been proposed as an experimental approach for the treatment of disorders of consciousness (DOC), but in subjects with TBI therapeutic effects on DOC have also been variously documented. Beneficial effects have been reported in subjects with cognitive/emotional disturbances and auditory dysfunction (tinnitus and hallucinations), although the results are somewhat conflicting. rTMS applied over the left prefrontal cortex may relieve, at least transiently, post-traumatic headache. Isolated rTMS studies have been performed in TBI patients with motor impairment, chronic dizziness or pain. Especially whether provided in combination, rTMS and neurorehabilitation may be synergistic in the potential to translate experimental findings in the clinical practice. In order to reach definitive conclusions, well-designed randomized controlled studies with larger patient samples, improved design and optimized rTMS setup, are warranted to verify and corroborate the initial promising findings.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87fbd75f4b078086f44fe8b0231a64cTest
https://doi.org/10.1016/j.brainresbull.2020.03.016Test

المؤلفون: Roberta Grassi, Luca Boldrini, Valerio Nardone, Davide Franceschini, Daniela Greto, Carlotta Becherini, Isacco Desideri, Mauro Loi, Ilaria Morelli

المساهمون: Nardone, V., Boldrini, L., Franceschini, D., Morelli, I., Becherini, C., Loi, M., Greto, D., Desideri, I., Grassi, R.

المصدر: Cancers
Cancers, Vol 13, Iss 3590, p 3590 (2021)

مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, Colorectal cancer, medicine.medical_treatment, Review, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Radiomics, Internal medicine, Medicine, Lung cancer, RC254-282, Neoadjuvant therapy, texture analysis, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Esophageal cancer, medicine.disease, Radiation therapy, neoadjuvant radiotherapy, radiomics, 030220 oncology & carcinogenesis, Sarcoma, Radiomic, business, Chemoradiotherapy

الوصف: Simple Summary This review based on a literature search aims at showing the impact of Texture Analysis in the prediction of response to neoadjuvant radiotherapy and/or chemoradiotherapy. The manuscript explores radiomics approaches in different fields of neoadjuvant radiotherapy, including esophageal cancer, lung cancer, sarcoma and rectal cancer in order to shed a light in the setting of neoadjuvant radiotherapy that can be used to tailor the best subsequent therapeutical strategy. Abstract Introduction: Neoadjuvant radiotherapy is currently used mainly in locally advanced rectal cancer and sarcoma and in a subset of non-small cell lung cancer and esophageal cancer, whereas in other diseases it is under investigation. The evaluation of the efficacy of the induction strategy is made possible by performing imaging investigations before and after the neoadjuvant therapy and is usually challenging. In the last decade, texture analysis (TA) has been developed to help the radiologist to quantify and identify the parameters related to tumor heterogeneity, which cannot be appreciated by the naked eye. The aim of this narrative is to review the impact of TA on the prediction of response to neoadjuvant radiotherapy and or chemoradiotherapy. Materials and Methods: Key references were derived from a PubMed query. Hand searching and ClinicalTrials.gov were also used. Results: This paper contains a narrative report and a critical discussion of radiomics approaches in different fields of neoadjuvant radiotherapy, including esophageal cancer, lung cancer, sarcoma, and rectal cancer. Conclusions: Radiomics can shed a light on the setting of neoadjuvant therapies that can be used to tailor subsequent approaches or even to avoid surgery in the future. At the same, these results need to be validated in prospective and multicenter trials.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3637222f8ea2f88baa87e7d486614107Test
http://europepmc.org/articles/PMC8303203Test

المؤلفون: F. Sasso, Elio Biffali, Anna Testa, Fabiana Castiglione, Francesco Manfellotto, Caterina D’Onofrio, Nicola Imperatore, Olga Maria Nardone, Alba Rocco, Roberto de Sire, Pasquale De Luca, Giovanni Annona

المساهمون: Nardone, O. M., Manfellotto, F., D'Onofrio, C., Rocco, A., Annona, G., Sasso, F., De Luca, P., Imperatore, N., Testa, A., de Sire, R., Biffali, E., Castiglione, F.

المصدر: Nutrients
Volume 13
Issue 4
Nutrients, Vol 13, Iss 1290, p 1290 (2021)

مصطلحات موضوعية: Adult, Male, Breath Test, medicine.medical_specialty, medicine.medical_treatment, Population, Lactose, lcsh:TX341-641, Polymorphism, Single Nucleotide, Inflammatory bowel disease, Gastroenterology, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, inflammatory bowel disease, Internal medicine, Elimination diet, Genotype, Prevalence, medicine, Humans, Prospective Studies, Genetic Testing, lactase polymorphism, education, Lactase, Breath test, Lactose intolerance, education.field_of_study, Nutrition and Dietetics, medicine.diagnostic_test, business.industry, Middle Aged, Inflammatory Bowel Diseases, medicine.disease, Prospective Studie, lactose intolerance, Breath Tests, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, business, lcsh:Nutrition. Foods and food supply, Hydrogen breath test, Human, Hydrogen, Food Science, hydrogen breath test

الوصف: Many patients with inflammatory bowel disease (IBD) restrict dairy products to control their symptoms. The aim of the study was to investigate the prevalence of lactose intolerance assessed with hydrogen breath test (H-BT) in IBD patients in clinical remission compared to a sex, age and BMI matched control population. We further detected the prevalence of three single nucleotide polymorphisms of the lactase (LCT) gene: the lactase non persistence LCT-13910 CC (wildtype) and the intermediate phenotype LCT-22018 CT and LCT-13910 AG
finally, we assess the correlation between genotype and H-BT. A total of 54 IBD patients and 69 control who underwent clinical evaluation, H-BT and genetic test were enrolled. H-BT was positive in 64.8% IBD patients and 62.3% control (p = 0.3). The wild-type genotype was found in 85.2% IBD patients while CT-22018, AG-13910 and CT-22018/AG-13910 polymorphisms were found in 9.3%, 1.8% and 3.7%. In the control group, the wild-type genotype, CT-22018, AG-13910 and CT-22018/AG-13910 polymorphisms were found in 87%, 5.8%, 5.8% and 1.4% of cases, respectively. Therefore, the wild-type and polymorphisms’ prevalence did not differ between IBD population and control group (85.2% vs. 87%, p = 0.1) (14.8% vs. 13%, p = 0.7). The correlation between positive H-BT and genetic analysis showed that the wild-type genotype was associated with higher rate of lactose intolerance in the total population (OR 5.31, 95%CI 1.73–16.29, p = 0.003) and in the IBD (OR 7.61, 95%CI 1.36–42.7, p = 0.02). The prevalence of lactose intolerance in IBD patients did not differ from that of control. Despite suggestive symptoms, about 1/3 of IBD patients are not lactose intolerant, thus not needing “a priori” elimination diet. This may encourage a rationale and balanced dietary management in IBD.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1508d6b25f01830609335fc701352053Test
http://europepmc.org/articles/PMC8070715Test