يعرض 1 - 10 نتائج من 14 نتيجة بحث عن '"Iris T Chan"', وقت الاستعلام: 1.13s تنقيح النتائج
  1. 1
    A phase Ib open-label dose escalation study of the safety, pharmacokinetics, and pharmacodynamics of cobimetinib (GDC-0973) and ipatasertib (GDC-0068) in patients with locally advanced or metastatic solid tumors

    المؤلفون: Ilsung Chang, Johanna C. Bendell, Raymond D. Meng, Premal Patel, Sandra M. Sanabria-Bohórquez, Daniel C. Cho, Patricia LoRusso, Matthew Wongchenko, Geoffrey I. Shapiro, Iris T. Chan, Yibing Yan, Luna Musib

    المصدر: Investigational New Drugs. 39:163-174

    مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Oncology, Cobimetinib, medicine.medical_specialty, business.industry, Endometrial cancer, medicine.disease, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Breast cancer, Tolerability, Pharmacokinetics, chemistry, 030220 oncology & carcinogenesis, Internal medicine, Pharmacodynamics, medicine, Pharmacology (medical), business, Ovarian cancer, Adverse effect

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b9452c83b98676f0b80dbf0103f07238Test
    https://doi.org/10.1007/s10637-020-00975-6Test


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  2. 2
    Abstract PD5-10: A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-0927, in postmenopausal women with estrogen receptor positive (ER+) HER2-negative metastatic breast cancer (BC)

    المؤلفون: J.A. Perez Fidalgo, Luna Liu, Antonio González-Martín, U McCurry, J. Cortés, Margaret A. Gates, Jill Fredrickson, Lars Mueller, Xiaojing Wang, Jennifer O. Lauchle, Ingrid A. Mayer, EP Winer, Roland Morley, Jennifer M. Giltnane, Erika Hamilton, Sravanthi Cheeti, R Villanueva, Lori Friedman, Ander Urruticoechea, Maura N. Dickler, Eric W. Humke, Iris T. Chan, S Milan, Meritxell Bellet, Jill M. Spoerke, M. Martin, Aditya Bardia, Valentina Boni, Ciara Metcalfe, Robert Jinze Li

    المصدر: Cancer Research. 78:PD5-10

    مصطلحات موضوعية: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, medicine.drug_class, business.industry, Estrogen receptor, medicine.disease, Metastatic breast cancer, 03 medical and health sciences, 030104 developmental biology, Breast cancer, Pharmacokinetics, Estrogen, Internal medicine, Pharmacodynamics, medicine, Adverse effect, business, Estrogen receptor alpha

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b6d1e958cce9b58ebb9ab3905b547b39Test
    https://doi.org/10.1158/1538-7445.sabcs17-pd5-10Test


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  3. 3
    A first-in-human phase I study to evaluate the MEK1/2 inhibitor, cobimetinib, administered daily in patients with advanced solid tumors

    المؤلفون: Lee S. Rosen, Angela Shen, Amy Weise, Jonathan W. Goldman, A. Dimitrios Colevas, Alex A. Adjei, Salim Yazji, Hsin Ju Hsieh, Iris T. Chan, Patricia LoRusso, Branimir I. Sikic, Wen Wee Ma, Stuart Johnston

    المصدر: Investigational new drugs, vol 34, iss 5

    مصطلحات موضوعية: Male, 0301 basic medicine, MAP Kinase Kinase 2, MAP Kinase Kinase 1, Pharmacology, Gastroenterology, chemistry.chemical_compound, 0302 clinical medicine, Piperidines, Neoplasms, Cobimetinib, 80 and over, Pharmacology (medical), Melanoma, ras, Cancer, Aged, 80 and over, MEK inhibitor, Pharmacology and Pharmaceutical Sciences, Middle Aged, Rash, Treatment Outcome, Oncology, 6.1 Pharmaceuticals, 030220 oncology & carcinogenesis, Vomiting, Female, medicine.symptom, Proto-Oncogene Proteins B-raf, Adult, medicine.medical_specialty, Maximum Tolerated Dose, Class I Phosphatidylinositol 3-Kinases, Nausea, Clinical Trials and Supportive Activities, Antineoplastic Agents, Article, BRAF, Proto-Oncogene Proteins p21(ras), Vaccine Related, 03 medical and health sciences, Phase I, Pharmacokinetics, Clinical Research, Internal medicine, medicine, Humans, Oncology & Carcinogenesis, Adverse effect, Protein Kinase Inhibitors, Aged, business.industry, Evaluation of treatments and therapeutic interventions, Genes, ras, 030104 developmental biology, Genes, chemistry, Pharmacodynamics, Mutation, Azetidines, business

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361923aa9fba431e1a3e3e602c6cb5c0Test
    https://doi.org/10.1007/s10637-016-0374-3Test


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  4. 4
    Combination of vemurafenib and cobimetinib in patients with advanced BRAFV600-mutated melanoma: a phase 1b study

    المؤلفون: Rene Gonzalez, Adil Daud, Ming Yin, Omid Hamid, Peter D. Boasberg, Karl D. Lewis, Anna C. Pavlick, Luna Musib, Igor Puzanov, Grant A. McArthur, Theodore F. Logan, Damien Kee, Thomas F. Gajewski, Antoni Ribas, Lawrence E. Flaherty, Iris T. Chan, Bartosz Chmielowski, Nicholas Choong

    المصدر: The Lancet Oncology. 15:954-965

    مصطلحات موضوعية: Male, Indoles, Skin Neoplasms, Pharmacology, Gastroenterology, chemistry.chemical_compound, Piperidines, Medicine, Prospective Studies, Infusions, Intravenous, Vemurafenib, Melanoma, Sulfonamides, MEK inhibitor, Middle Aged, Rash, Survival Rate, Treatment Outcome, Oncology, Drug Therapy, Combination, Female, medicine.symptom, medicine.drug, Adult, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Maximum Tolerated Dose, Risk Assessment, Disease-Free Survival, Drug Administration Schedule, Internal medicine, Humans, Neoplasm Invasiveness, Adverse effect, Protein Kinase Inhibitors, Survival rate, Aged, Neoplasm Staging, Cobimetinib, Dose-Response Relationship, Drug, business.industry, Patient Selection, Dabrafenib, medicine.disease, chemistry, Mutation, Azetidines, business, Follow-Up Studies

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f37e6205efc353876207a88d307180Test
    https://doi.org/10.1016/s1470-2045Test(14)70301-8


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  5. 5
    Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant

    المؤلفون: Junko Aimi, Steven Gendreau, Peter Schmid, Ian E. Krop, Meng Chen, Stephen T. Johnston, Mark R. Lackner, Garret Hampton, Mika K. Derynck, Kimberly Walter, Jiaheng Qiu, Lukas C. Amler, Heidi Savage, Timothy R. Wilson, Iris T. Chan, Jill M. Spoerke

    المصدر: Nature Communications
    Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)

    مصطلحات موضوعية: 0301 basic medicine, Oncology, DNA Mutational Analysis, General Physics and Astronomy, Drug resistance, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, Breast, skin and connective tissue diseases, Fulvestrant, Aged, 80 and over, Sulfonamides, Multidisciplinary, Estradiol, DNA, Neoplasm, Middle Aged, Metastatic breast cancer, 030220 oncology & carcinogenesis, Female, medicine.drug, Adult, medicine.medical_specialty, Indazoles, medicine.drug_class, Class I Phosphatidylinositol 3-Kinases, Science, Breast Neoplasms, General Biochemistry, Genetics and Molecular Biology, Article, Disease-Free Survival, 03 medical and health sciences, Internal medicine, medicine, Humans, Clinical significance, Allele frequency, Protein Kinase Inhibitors, Aged, Aromatase inhibitor, business.industry, Estrogen Receptor alpha, Estrogens, General Chemistry, medicine.disease, Clinical trial, body regions, 030104 developmental biology, Endocrinology, Drug Resistance, Neoplasm, Mutation, Estrogen Receptor Antagonists, business, Estrogen receptor alpha

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9793ee4d0117eafc5f817a18176c60Test
    http://europepmc.org/articles/PMC4869259Test


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  6. 6
    Dogs Are More Sensitive to Antagonists of Inhibitor of Apoptosis Proteins Than Rats and Humans: A Translational Toxicokinetic/Toxicodynamic Analysis

    المؤلفون: Elizabeth Blackwood, Patricia LoRusso, Joseph A. Ware, S. Gail Eckhardt, Wayne J. Fairbrother, Iris T. Chan, Rebecca Erickson, Stephen E. Gould, Andrew J. Wagner, John A. Flygare, Ron Yu, Ronald Steigerwalt, Kristina West, Walter C. Darbonne, Harvey Wong, Cornelis E. A. C. Hop, Michael Mamounas, Nageshwar Budha

    المصدر: Toxicological Sciences. 130:205-213

    مصطلحات موضوعية: Male, medicine.medical_specialty, Apoptosis Inhibitor, medicine.medical_treatment, Population, Drug Evaluation, Preclinical, Context (language use), Biology, Pharmacology, Toxicology, Inhibitor of apoptosis, Models, Biological, Inhibitor of Apoptosis Proteins, Rats, Sprague-Dawley, Dogs, Species Specificity, Cyclohexanes, Internal medicine, medicine, Animals, Humans, Pyrroles, education, education.field_of_study, Caspase Inhibitors, Rats, XIAP, Cytokine, Endocrinology, Apoptosis, Area Under Curve, Injections, Intravenous, Cytokines, Female, Tumor necrosis factor alpha, Half-Life

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a21d76a5ce1a57ccfb2adfbd4f06d84Test
    https://doi.org/10.1093/toxsci/kfs235Test


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  7. 7
    Successful Treatment of Angioinvasive Aspergillosis During Prolonged Neutropenia with Liposomal Amphotericin, Voriconazole, and Caspofungin

    المؤلفون: Susan S. Huang, Lindsey R. Baden, Richard Stone, Iris T. Chan

    المصدر: Huang, SS; Chan, IT; Stone, RM; & Baden, LR. (2002). Successful treatment of angioinvasive aspergillosis during prolonged neutropenia with liposomal amphotericin, voriconazole, and caspofungin. Infectious Diseases in Clinical Practice, 11(6), 355-358. doi: 10.1097/01.idc.0000078754.71576.ce. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8ts5f2sjTest

    مصطلحات موضوعية: Microbiology (medical), Voriconazole, medicine.medical_specialty, business.industry, Neutropenia, Aspergillosis, medicine.disease, Gastroenterology, chemistry.chemical_compound, Infectious Diseases, chemistry, Internal medicine, medicine, Liposomal amphotericin, Caspofungin, business, medicine.drug

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb7288dba25d705db44360b4b7351ccTest
    https://doi.org/10.1097/01.idc.0000078754.71576.ceTest


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  8. 8
    Abstract PD6-03: High prevalence and clonal heterogeneity of ESR1 mutations (mt) in circulating tumor DNA (ctDNA) from patients (pts) enrolled in FERGI, a randomized phase II study testing pictilisib (GDC-0941) in combination with fulvestrant (F) in pts that failed a prior aromatase inhibitor (AI)

    المؤلفون: Steven Gendreau, Stephen T. Johnston, Ian E. Krop, Mika K. Derynck, J Qui, Peter Schmid, Kimberly Walter, G. Hampton, Lukas C. Amler, Mark R. Lackner, Jill M. Spoerke, Iris T. Chan

    المصدر: Cancer Research. 76:PD6-03

    مصطلحات موضوعية: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Pathology, medicine.drug_class, Luma, Phases of clinical research, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Internal medicine, medicine, Digital polymerase chain reaction, Allele frequency, Aromatase inhibitor, Fulvestrant, business.industry, medicine.disease, body regions, 030104 developmental biology, 030220 oncology & carcinogenesis, business, Estrogen receptor alpha, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a043109642edc056cb6c72ccb8e4db08Test
    https://doi.org/10.1158/1538-7445.sabcs15-pd6-03Test


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  9. 9
    Abstract CT231: A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader GDC-0810 (ARN-810) in postmenopausal women with estrogen receptor+ HER2-, advanced/metastatic breast cancer

    المؤلفون: Carlos L. Arteaga, Edna Chow-Maneval, Eric P. Winer, Aditya Bardia, Maura N. Dickler, José Baselga, Meng Chen, Jeff Hager, Ingrid A. Mayer, Iris T. Chan, Peter J. Rix

    المصدر: Cancer Research. 75:CT231-CT231

    مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, Aromatase inhibitor, business.industry, medicine.drug_class, Estrogen receptor, medicine.disease, Metastatic breast cancer, Endocrinology, Breast cancer, Estrogen, Internal medicine, Pharmacodynamics, Medicine, business, Adverse effect, Estrogen receptor alpha

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::24e6dded178e4d5a4c8750155d8c6fd0Test
    https://doi.org/10.1158/1538-7445.am2015-ct231Test


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  10. 10
    Abstract B75: A first in-human phase I study to evaluate the MEK1/2 inhibitor GDC-0623 in patients with advanced solid tumors

    المؤلفون: Johanna C. Bendell, Steve Eppler, Thomas J. Semrad, Mary Gates, Anthony B. El-Khoueiry, Iris T. Chan, Ilsung Chang, Luna Musib, Isabelle Rooney, Carla Kurkjian

    المصدر: Molecular Cancer Therapeutics. 12:B75-B75

    مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, business.industry, Nausea, Peripheral edema, Gastroenterology, Rash, Regimen, Oncology, Pharmacokinetics, Internal medicine, medicine, Vomiting, Dosing, medicine.symptom, business, Adverse effect

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::2cc191fc4833bf0f15ffa13e121ed1c7Test
    https://doi.org/10.1158/1535-7163.targ-13-b75Test


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