المؤلفون: D. D. Morikov, V. V. Kartashova, M. M. Demchenkova, A. L. Khoroshikh

المصدر: Acta Biomedica Scientifica, Vol 6, Iss 1, Pp 26-32 (2021)

مصطلحات موضوعية: medicine.medical_specialty, medicine.medical_treatment, Science, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, law.invention, Sepsis, 03 medical and health sciences, 0302 clinical medicine, law, Internal medicine, medicine, hiv-associated non-hodgkin’s lymphoma, 030212 general & internal medicine, Renal replacement therapy, 0101 mathematics, myelosuppression, Chemotherapy, General Immunology and Microbiology, Septic shock, business.industry, nosocomial pneumonia, 010102 general mathematics, Immunosuppression, medicine.disease, Intensive care unit, Pneumonia, Pneumothorax, septic shock, business, renal replacement therapy

الوصف: This article presents a clinical case of successful treatment of gram-negative sepsis in a patient with HIV-associated non-Hodgkin’s lymphoma. The patient was admitted to the intensive care unit in critical condition after the third course of polychemotherapy according to the ICE scheme. The severity of the condition was due to nosocomial pneumonia, septic shock, multiple organ failure, immunosuppression against the background of PCT and HIV infection, and the lack of specific treatment for HIV infection. Despite the absence of a positive blood culture throughout the entire treatment period, the diagnosis of sepsis was not in doubt, according to the criteria of the 2001 International Consensus Conference on Sepsis. The cause of the septic state was the combined effect of bacteria (Pseudomonas aeruginosa) and fungi (Candida albicans, Candida krusei) against the background of persistent HIV infection. The patient’s pneumonia was destructive and was twice aggravated by spontaneous pneumothorax. At the initial stage, intensive therapy led to positive dynamics. The severity of the systemic inflammatory response decreased, the acute respiratory insufficiency regressed, the X-ray pattern improved, and laboratory parameters stabilized. Despite the continued intensive therapy in the former volume on day 19, a sharply negative dynamics was noted, which led to a re-transfer of the patient to artificial ventilation of the lungs. The replacement of antibiotics and the specific treatment of HIV infection led to the patient’s recovery. In the future, chemotherapy was not carried out. Remission of the disease lasts six years.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09b4139463e75c7c834710e6ec4b5b7Test
https://www.actabiomedica.ru/jour/article/view/2607Test

المؤلفون: D. D. Morikov, A. V. Shelekhov, V. I. Gorbachev, V. V. Dvornichenko, A. G. Pavlov, S. I. Radostev, I. I. Osadchiy, T. G. Zyabreva

المصدر: Вестник анестезиологии и реаниматологии, Vol 16, Iss 5, Pp 24-30 (2019)

مصطلحات موضوعية: medicine.medical_specialty, RC86-88.9, business.industry, medicine.drug_class, Anesthetic management, Medical emergencies. Critical care. Intensive care. First aid, Critical Care and Intensive Care Medicine, medicine.disease, hyperthermic intraperitoneal chemotherapy, Resection, ovarian cancer, Anesthesiology and Pain Medicine, anesthetic aid, Anesthesia, Anesthesiology, Anesthetic, Emergency Medicine, medicine, cytoreductive surgery, Antiemetic, Hyperthermic intraperitoneal chemotherapy, In patient, Ovarian cancer, business, medicine.drug

الوصف: The objective of the study : to analyze the experience of anesthesia when performing cytoreductive surgeries using hyperthermic intraperitoneal chemotherapy in patients with advanced forms of ovarian cancer. Subjects and methods . A pilot study of anesthetic management was conducted in 30 patients with ovarian cancer who underwent multiorgan cytoreductive abdominal resection with hyperthermic intraperitoneal chemotherapy. Results . The risk of anesthesia was 5.18 ± 0.39 points (which corresponded to the III degree of risk) according to the recommendations of the Moscow Scientific Society of Anesthesiology Reanimatology (MSSAR). The total volume of infusion‒transfusion therapy (ITT) was 11.070,0 ± 2.243,5 ml. with the hour rate of 21.7 ± 6.1 ml/kg-1/h-1, due to increase in the volume of crystalloids. Important components of anesthetic management were the patient's thermal stability and antiemetic therapy. Conclusion . As a result of the study, it was revealed that anesthesia in patients during cytoreductive operations with HIPEC was fairly complex and required the participation of a well-trained anesthesiological team. The issue of choosing the scale to assess anesthetic risk due to the lack of optimal one for this type of operations, requires further research. Although in our opinion, the scale of anesthesiological risk of the Moscow Scientific Society of Anesthesiologists-Resuscitators is more preferable. In such operations, the volume of ITT should be increased primarily through balanced crystalloids.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c779db73efb30d794801d6c4b09ef42dTest
https://doi.org/10.21292/2078-5658-2019-16-5-24-30Test

المؤلفون: A. V. Shelekhov, V. V. Dvornichenko, S. I. Radostev, D. D. Morikov, R. I. Rasulov, I. V. Ushakova, A. A. Medvednikov, A. G. Zaharov, R. N. Demonov, O. V. Gladkova, N. M. Chernorubashkina

المصدر: Sibirskij Onkologičeskij Žurnal, Vol 17, Iss 3, Pp 58-63 (2018)

مصطلحات موضوعية: Cancer Research, Study groups, medicine.medical_specialty, business.industry, Group ii, peritoneal carcinomatosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, ovarian cancer, medicine.disease, Peritoneal carcinomatosis, Surgery, 03 medical and health sciences, 0302 clinical medicine, Oncology, Regional cancer, 030220 oncology & carcinogenesis, medicine, cytoreductive surgery, 030212 general & internal medicine, Cytoreductive surgery, Ovarian cancer, business, hipec, RC254-282

الوصف: We present our experience in using cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for ovarian cancer patients treated at Irkutsk Regional Cancer Center. All patients were divided into 2 groups. Group I consisted of 15 patients, who underwent cytoreductive surgery only. Group II comprised 17 patients, who underwent surgery and HIPEC. The main eligibility criteria for this study were verified peritoneal carcinomatosis and resectable ovarian cancer. The primary analysis of these groups included: preoperative period, length of operation, postoperative length of stay, and postoperative complications. The technique of performing HIPEC using Performer HT® (RAND, Medolla (MO), Italy) was completely described. Further study is required to estimate the difference in overall and disease-free survival between study groups.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2909c78d53c8053a3e2ac6d31982014Test
https://www.siboncoj.ru/jour/article/view/764Test

المؤلفون: R. I. Rasulov, A. A. Muratov, V. V. Dvornichenko, D. D. Morikov, Y. K. Batoroev, G. I. Songolov

المصدر: Transplantologiâ, Vol 9, Iss 2, Pp 118-124 (2017)

مصطلحات موضوعية: medicine.medical_specialty, medicine.medical_treatment, Immunology, Ischemia, Locally advanced, Liposarcoma, extracorporeal surgery, Extracorporeal, non-organ retroperitoneal tumor, Cytology, nephrectomy, medicine, Immunology and Allergy, Transplantation, Rehabilitation, business.industry, medicine.disease, Nephrectomy, Autotransplantation, Surgery, liposarcoma, Medicine, business, kidney autotransplantation

الوصف: The paper presents the analysis of 5 clinical cases that demonstrate the potential of using organ-saving technologies in surgery of locally advanced retroperitoneal sarcomas. The clinical example shows step by step the technique of organ-preserving surgical intervention: an extended tumour nephrectomy followed by the extracorporeal precise dissection of the kidney from the tumor bulk with inducing a reversible pharmaco-cold ischemia and the isolated kidney autotransplantation into a heterotopic position with regard to intraoperative rapid cytology monitoring results. The article describes the characteristics of anesthesia, the early postoperative period, subsequent rehabilitation, and prophylactic medical screening of this group of patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c3942329f3c0170eca9f704574bc9fTest
https://doi.org/10.23873/2074-0506-2017-9-2-118-124Test

المؤلفون: V.V. Dvornichenko, A.V. Shelekhov, D. D. Morikov, S.I. Radostev, R. I. Rasulov, A.A. Medvednikov, N. A. Nikolaeva

المصدر: Onkologiya. Zhurnal imeni P.A.Gertsena. 9:5

مصطلحات موضوعية: Oncology, medicine.medical_specialty, business.industry, Internal medicine, Medicine, Treatment results, business, Ovarian cancer, medicine.disease, Peritoneal carcinomatosis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::84df26e8668e8ad8f1260e5a0af8cd8fTest
https://doi.org/10.17116/onkolog202090615Test