Importance of genetic screens in precision oncology
| العنوان: | Importance of genetic screens in precision oncology |
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| المؤلفون: | Ziva Pogacar, Antonio Mulero-Sánchez, Loredana Vecchione |
| المصدر: | ESMO Open ESMO Open, Vol 4, Iss 3 (2019) |
| بيانات النشر: | Elsevier BV, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Computer science, Review, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, targeted therapy, lcsh:RC254-282, synthetic lethality, Cancer treatment, Oncology, mechanisms of resistance, Precision oncology, precision oncology, medicine, Medical physics, genetic screens, Predictive biomarker, Genetic screen |
| الوصف: | Precision oncology aims to distinguish which patients are eligible for a specific treatment in order to achieve the best possible outcome. In the last few years, genetic screens have shown their potential to find the new targets and drug combinations as well as predictive biomarkers for response and/or resistance to cancer treatment. In this review, we outline how precision oncology is changing over time and describe the different applications of genetic screens. Finally, we present some practical examples that describe the utility and the limitations of genetic screens in precision oncology. |
| تدمد: | 2059-7029 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4de52844baa970d91c8d0a0e788d79Test https://doi.org/10.1136/esmoopen-2019-000505Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5e4de52844baa970d91c8d0a0e788d79 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20597029 |
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