A Case of Successful Treatment of Gram-Negative Sepsis Associated with Toxic Myelosuppression in a Patient with HIV-Associated Non-Hodgkin’s Lymphoma
| العنوان: | A Case of Successful Treatment of Gram-Negative Sepsis Associated with Toxic Myelosuppression in a Patient with HIV-Associated Non-Hodgkin’s Lymphoma |
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| المؤلفون: | D. D. Morikov, V. V. Kartashova, M. M. Demchenkova, A. L. Khoroshikh |
| المصدر: | Acta Biomedica Scientifica, Vol 6, Iss 1, Pp 26-32 (2021) |
| بيانات النشر: | Scientific Сentre for Family Health and Human Reproduction Problems, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.medical_treatment, Science, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, law.invention, Sepsis, 03 medical and health sciences, 0302 clinical medicine, law, Internal medicine, medicine, hiv-associated non-hodgkin’s lymphoma, 030212 general & internal medicine, Renal replacement therapy, 0101 mathematics, myelosuppression, Chemotherapy, General Immunology and Microbiology, Septic shock, business.industry, nosocomial pneumonia, 010102 general mathematics, Immunosuppression, medicine.disease, Intensive care unit, Pneumonia, Pneumothorax, septic shock, business, renal replacement therapy |
| الوصف: | This article presents a clinical case of successful treatment of gram-negative sepsis in a patient with HIV-associated non-Hodgkin’s lymphoma. The patient was admitted to the intensive care unit in critical condition after the third course of polychemotherapy according to the ICE scheme. The severity of the condition was due to nosocomial pneumonia, septic shock, multiple organ failure, immunosuppression against the background of PCT and HIV infection, and the lack of specific treatment for HIV infection. Despite the absence of a positive blood culture throughout the entire treatment period, the diagnosis of sepsis was not in doubt, according to the criteria of the 2001 International Consensus Conference on Sepsis. The cause of the septic state was the combined effect of bacteria (Pseudomonas aeruginosa) and fungi (Candida albicans, Candida krusei) against the background of persistent HIV infection. The patient’s pneumonia was destructive and was twice aggravated by spontaneous pneumothorax. At the initial stage, intensive therapy led to positive dynamics. The severity of the systemic inflammatory response decreased, the acute respiratory insufficiency regressed, the X-ray pattern improved, and laboratory parameters stabilized. Despite the continued intensive therapy in the former volume on day 19, a sharply negative dynamics was noted, which led to a re-transfer of the patient to artificial ventilation of the lungs. The replacement of antibiotics and the specific treatment of HIV infection led to the patient’s recovery. In the future, chemotherapy was not carried out. Remission of the disease lasts six years. |
| اللغة: | Russian |
| تدمد: | 2587-9596 2541-9420 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09b4139463e75c7c834710e6ec4b5b7Test https://www.actabiomedica.ru/jour/article/view/2607Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c09b4139463e75c7c834710e6ec4b5b7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25879596 25419420 |
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