نتائج البحث - "Thiazepines"

1

Elobixibat, an ileal bile acid transporter inhibitor, ameliorates non-alcoholic steatohepatitis in mice

المؤلفون: Keiji Yokoyama, Kazuhide Takata, Yotaro Uchida, Takahiro Nagata, Motoko Kawashima, Yasuaki Takeyama, Ryo Yamauchi, Shotaro Sakisaka, Fumihito Hirai, Takashi Tanaka, Hiromi Fukuda, Naoaki Tsuchiya, Satoshi Shakado, Hidetoshi Takedatsu, Takanori Kitaguchi, Tomotaka Higashi, Eri Yamauchi, Daisuke Morihara

المصدر: Hepatology International. 15:392-404

مصطلحات موضوعية: medicine.medical_specialty, Thiazepines, medicine.drug_class, Gut flora, Proinflammatory cytokine, Mice, 03 medical and health sciences, 0302 clinical medicine, Ileum, Non-alcoholic Fatty Liver Disease, Fibrosis, Internal medicine, medicine, Animals, Mesenteric lymph nodes, Membrane Glycoproteins, Hepatology, biology, Tight junction, Bile acid, business.industry, nutritional and metabolic diseases, Dipeptides, biology.organism_classification, medicine.disease, Intestinal epithelium, Mice, Inbred C57BL, Disease Models, Animal, medicine.anatomical_structure, Endocrinology, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Steatohepatitis, Carrier Proteins, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cbd61ff6065448966533f805af88c22Test
https://doi.org/10.1007/s12072-020-10107-0Test

2

The benefit of elobixibat in chronic constipation is associated with faecal deoxycholic acid but not effects of altered microbiota

المصدر: Alimentary Pharmacology & Therapeutics. 52:821-828

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Organic anion transporter 1, Colon, Thiazepines, medicine.drug_class, Organic Anion Transporters, Sodium-Dependent, Gut flora, digestive system, Gastroenterology, Bile Acids and Salts, Feces, 03 medical and health sciences, chemistry.chemical_compound, fluids and secretions, 0302 clinical medicine, Elobixibat, Internal medicine, medicine, Humans, Pharmacology (medical), Prospective Studies, 030212 general & internal medicine, Defecation, Aged, Chronic constipation, Symporters, Hepatology, biology, Bile acid, business.industry, Microbiota, digestive, oral, and skin physiology, Deoxycholic acid, Dipeptides, Middle Aged, biology.organism_classification, chemistry, Symporter, biology.protein, Female, 030211 gastroenterology & hepatology, business, Constipation, Deoxycholic Acid

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f454e52d53ce6a7ce6f339d395141bTest
https://doi.org/10.1111/apt.15950Test

3

Mu opioid receptors on hippocampal GABAergic interneurons are critical for the antidepressant effects of tianeptine

المؤلفون: John E. Pintar, Brigitte L. Kieffer, Cory Langreck, Elizabeth A. Pekarskaya, Alexander Z. Harris, Steven G. Grinnell, Katherine M. Nautiyal, Florence Allain, Jaena Han, Valerie M. Magalong, Valentine Andreu, Jonathan A. Javitch, René Hen

المساهمون: Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie (NCPS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Civil de Strasbourg, RGA-13-003

المصدر: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021, ⟨10.1038/s41386-021-01192-2⟩
Neuropsychopharmacology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f43c2ef1072141f27ceffaf631c574Test
https://hal.archives-ouvertes.fr/hal-03408174Test

4

Selective inhibition of the C-domain of ACE (angiotensin-converting enzyme) combined with inhibition of NEP (neprilysin): a potential new therapy for hypertension

المؤلفون: Augusto C. Montezano, Tomasz J. Guzik, Karla B Neves, Marko Poglitsch, Francisco J. Rios, Lauren B. Arendse, Rhian M. Touyz, Delyth Graham, Rheure Alves-Lopes, Dominik Skiba, Adam Harvey, Edward D. Sturrock

المصدر: Hypertension (Dallas, Tex. : 1979)

مصطلحات موضوعية: 0301 basic medicine, Pyridines, Thiazepines, medicine.drug_class, Antihypertensive Treatment, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Mice, Transgenic, Vascular permeability, 030204 cardiovascular system & hematology, Pharmacology, Sacubitril, neprilysin, Mice, 03 medical and health sciences, 0302 clinical medicine, Lisinopril, Renin, Internal Medicine, medicine, Animals, Antihypertensive drug, Antihypertensive Agents, omapatrilat, business.industry, Aminobutyrates, Biphenyl Compounds, Body Weight, Original Articles, Angiotensin II, vasodilatation, 030104 developmental biology, Blood pressure, Liver, Hypertension, ACE inhibitor, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Omapatrilat, permeability, business, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8afd3013f11178a080b96fbfbaecb1fTest
https://eprints.gla.ac.uk/245083/1/245083.pdfTest

5

Combined ASBT Inhibitor and FGF15 Treatment Improves Therapeutic Efficacy in Experimental Nonalcoholic Steatohepatitis

المؤلفون: Wen-Xing Ding, Lijie Gu, Wenyi Luo, Rachel R. Sharp, Tiangang Li, Kenneth Jones, Cheng Chen, Huaiwen Wang, David J. Matye, Jacob E. Friedman

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1001-1019 (2021)

مصطلحات موضوعية: 0301 basic medicine, Male, CYP7A1, Thiazepines, RC799-869, AST, aspartate aminotransferase, Pharmacology, GSK672, GSK2330672, Mice, Bile Acids, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, CYP7A1, cholesterol 7a-hydroxylase, ANOVA, analysis of variance, Original Research, ASBT, apical sodium-bile acid transporter, Bile acid, TG, triglyceride, Intestinal lipid absorption, Fatty liver, Gastroenterology, NASH, Diseases of the digestive system. Gastroenterology, Dependovirus, cholesterol, and fructose diet, Combined Modality Therapy, FGF-15, fibroblast growth factor-15, Cholesterol, Treatment Outcome, NAFL, nonalcoholic fatty liver, Liver Fibrosis, 030211 gastroenterology & hepatology, NASH, nonalcoholic steatohepatitis, medicine.drug_class, Genetic Vectors, Fructose, Cholesterol 7 alpha-hydroxylase, SEM, standard error of the mean, digestive system, Bile Acids and Salts, 03 medical and health sciences, Methylamines, FXR, farnesoid X receptor, ALT, alanine aminotransferase, medicine, Animals, Hepatology, business.industry, FGF15, Gene Expression Profiling, RNA-seq, RNA sequencing, FGF19, Genetic Therapy, medicine.disease, HFCFr diet, high fat, Fibroblast Growth Factors, Fatty Liver, Disease Models, Animal, 030104 developmental biology, Gene Expression Regulation, NAS, NASH activity score, Steatohepatitis, Steatosis, business