المؤلفون: Ann M. Decker, Catherine M. Kotz, Vijayakumar Mavanji, Tiffany L. Langston, Dehui Zhang, Yanan Zhang, Danni L. Harris, David A. Perrey

المصدر: J Med Chem

مصطلحات موضوعية: Male, Agonist, medicine.drug_class, medicine.medical_treatment, Intraperitoneal injection, CHO Cells, Molecular Dynamics Simulation, Pharmacology, 01 natural sciences, Article, Mice, Structure-Activity Relationship, 03 medical and health sciences, Cricetulus, Orexin Receptors, Drug Discovery, medicine, Animals, Structure–activity relationship, Wakefulness, 030304 developmental biology, Sulfonamides, 0303 health sciences, Molecular Structure, biology, Chemistry, biology.organism_classification, medicine.disease, Small molecule, 0104 chemical sciences, Orexin, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Female, Sleep, Narcolepsy

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931ff980a0192e08e857b44e3b894b07Test
https://doi.org/10.1021/acs.jmedchem.1c00841Test

المؤلفون: Corey Strickland, Christina Minnick, Michael J. Breslin, Srivanya Tummala, Kaspar Hollenstein, Alexei Brooun, Vanessa L. Rada, Shawn J. Stachel, Beata Zamlynny, Kira A. Armacost, Dawn L. Hall, Li Xiao, Terrence P. McDonald, Chuan Hong, Kern Jeffrey, Scott A. Hollingsworth, Stephen M. Soisson, Julie A. O'Brien, Andrea T. Partridge, Jennifer M. Shipman, Michael T. Rudd, Noel Byrne

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications

مصطلحات موضوعية: Agonist, Protein Conformation, alpha-Helical, medicine.drug_class, Science, Genetic Vectors, General Physics and Astronomy, Aminopyridines, Gene Expression, Peptide, Plasma protein binding, Pharmacology, Molecular Dynamics Simulation, General Biochemistry, Genetics and Molecular Biology, Article, G protein-coupled receptors, Cryoelectron microscopy, Orexin Receptors, medicine, Escherichia coli, Humans, Protein Interaction Domains and Motifs, Cloning, Molecular, chemistry.chemical_classification, Sulfonamides, Multidisciplinary, Binding Sites, Chemistry, HEK 293 cells, digestive, oral, and skin physiology, General Chemistry, Azepines, Triazoles, medicine.disease, Small molecule, Orexin receptor, Recombinant Proteins, Orexin, HEK293 Cells, Sleep Aids, Pharmaceutical, Orexin Receptor Antagonists, Protein Conformation, beta-Strand, Peptides, Narcolepsy, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e52de5a726dc2d15e8ae787fb1b0817Test
https://doaj.org/article/71020c0fdeec442e80fbd53a66967a19Test

المؤلفون: Mostafa Lavaie, Alireza Komaki, Masoumeh Gholami, Mohammad Taghi Joghataei, Masoumeh Kourosh-Arami, Zohreh Najafi

المصدر: International Journal of Neuroscience. 132:67-76

مصطلحات موضوعية: Narcotics, 0301 basic medicine, medicine.drug_class, Narcotic Antagonists, (+)-Naloxone, Pharmacology, Nociceptive Pain, 03 medical and health sciences, 0302 clinical medicine, SB-334867, Animals, Urea, Medicine, Naphthyridines, Rats, Wistar, Benzoxazoles, Behavior, Animal, Morphine, Naloxone, business.industry, General Neuroscience, Antagonist, General Medicine, Receptor antagonist, Rats, Substance Withdrawal Syndrome, Blockade, Orexin, Disease Models, Animal, 030104 developmental biology, Nociception, Orexin Receptor Antagonists, business, Morphine Dependence, 030217 neurology & neurosurgery, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844c4f26276b4eea3e3af400fd7eee19Test
https://doi.org/10.1080/00207454.2020.1802266Test

المؤلفون: Jalal Zaringhalam, Shahrbanoo Oryan, Kobra Askari, Akram Eidi, Abbas Haghparast

المصدر: European Journal of Pain. 25:2266-2277

مصطلحات موضوعية: medicine.drug_class, Pain, Pharmacology, mental disorders, medicine, Noxious stimulus, Animals, Rats, Wistar, Receptor, Orexins, business.industry, musculoskeletal, neural, and ocular physiology, Ventral Tegmental Area, TCS-OX2-29, Receptor antagonist, Rats, Orexin, Ventral tegmental area, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Nociception, nervous system, Analgesia, business, psychological phenomena and processes, Tail flick test, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7ddb066c1978153eef3578c4bde04fTest
https://doi.org/10.1002/ejp.1840Test

المؤلفون: Konishi Toru, Kurazumi Takuya, Takko Chiharu, Kato Tomokazu, Iwasaki Ken-ichi, Ogawa Yojiro

المصدر: Journal of Nihon University Medical Association. 80:107-114

مصطلحات موضوعية: Agonist, Cerebral circulation, Benzodiazepine, Cerebral blood flow, medicine.drug_class, business.industry, Suvorexant, medicine, General Medicine, Pharmacology, business, Receptor, Orexin receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::218f9ab1f1a9477bb7cf87031617427bTest
https://doi.org/10.4264/numa.80.3_107Test

المؤلفون: Junji Furukawa, Chika Higashi, Shunsuke Maehara, Takashi Takeuchi, Takumi Ota, Natsuko Yuge

المصدر: Neuropsychopharmacology Reports

مصطلحات موضوعية: Male, Agonist, medicine.drug_class, Administration, Oral, CHO Cells, Pharmacology, OX1 receptor, Rats, Sprague-Dawley, Cricetulus, Orexin Receptors, In vivo, Cricetinae, medicine, Animals, Humans, Pharmacology (medical), sleep, Receptor, Orexins, Chemistry, Antagonist, Electroencephalography, Original Articles, OX2 receptor, Receptor antagonist, In vitro, Rats, Bioavailability, Orexin, Psychiatry and Mental health, Clinical Psychology, orexin, Original Article, Orexin Receptor Antagonists

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb587ea061a73b9b03f49de9c18959cTest
https://doi.org/10.1002/npr2.12105Test

المؤلفون: Benjamin Berger, Jasper Dingemanse, Priska Kaufmann, Annelize Koch

المصدر: The Journal of Clinical Pharmacology. 60:931-941

مصطلحات موضوعية: Adult, Male, Hydrocortisone, CYP3A, medicine.drug_class, Midazolam, Urinary system, Pharmacology, 030226 pharmacology & pharmacy, Drug Administration Schedule, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Orexin Receptors, medicine, Cytochrome P-450 CYP3A, Humans, Drug Interactions, Pharmacology (medical), Adverse effect, business.industry, Middle Aged, Receptor antagonist, Healthy Volunteers, Orexin, Area Under Curve, 030220 oncology & carcinogenesis, Concomitant, Cytochrome P-450 CYP3A Inhibitors, Orexin Receptor Antagonists, business, Biomarkers, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a45b1401d368d57cd1f5de0f8b1f73Test
https://doi.org/10.1002/jcph.1588Test

المؤلفون: Tadashi Saigusa, Masami Yamaguchi, Manabu Ishikawa, Yuri Aono

المصدر: Neuropsychopharmacology Reports. 40:30-38

مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, medicine.drug_class, Chemistry, Inhibitory postsynaptic potential, Receptor antagonist, Orexin receptor, Psychiatry and Mental health, Clinical Psychology, Orexin-A, Endocrinology, Nociception, medicine.anatomical_structure, nervous system, Dorsal root ganglion, Internal medicine, Hyperalgesia, medicine, Pharmacology (medical), Sciatic nerve, medicine.symptom

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5eac72e3908bb928f3992efda4eea0b2Test
https://doi.org/10.1002/npr2.12094Test

المؤلفون: Shunsuke Maehara, Takumi Ota, Junji Furukawa

المصدر: Pharmacological Reports. 71:1147-1150

مصطلحات موضوعية: Male, Agonist, medicine.medical_specialty, medicine.drug_class, Aminopyridines, Neuropeptide, Rats, Sprague-Dawley, 03 medical and health sciences, Orexin-A, 0302 clinical medicine, SB-334867, Orexin Receptors, Internal medicine, mental disorders, medicine, Animals, Urea, Naphthyridines, Receptor, Pharmacology, Benzoxazoles, Orexins, Sulfonamides, Chemistry, Neuropeptides, digestive, oral, and skin physiology, Antagonist, General Medicine, Receptor antagonist, Rats, Orexin, Endocrinology, nervous system, 030220 oncology & carcinogenesis, Locomotion, hormones, hormone substitutes, and hormone antagonists, psychological phenomena and processes, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5733e0058e411aba039f6523e0f641Test
https://doi.org/10.1016/j.pharep.2019.06.018Test

المؤلفون: Tetsuya Shiga, Yusuke Osakabe, Sho Horikoshi, Hiroshi Hoshino, Hirooki Yabe, Kazuko Kanno, Itaru Miura, Haruka Ochiai

المصدر: Journal of psychopharmacology (Oxford, England). 35(12)

مصطلحات موضوعية: Adult, Male, Side effect, medicine.drug_class, Mismatch negativity, Pharmacology, Lorazepam, 03 medical and health sciences, Benzodiazepines, Young Adult, 0302 clinical medicine, Discrimination, Psychological, Medicine, Humans, Pharmacology (medical), Cognitive Dysfunction, 030212 general & internal medicine, Cognitive decline, Benzodiazepine, business.industry, Suvorexant, Antagonist, Electroencephalography, Azepines, Triazoles, Event-Related Potentials, P300, Orexin receptor, Psychiatry and Mental health, Tolerability, Auditory Perception, Evoked Potentials, Auditory, Female, Orexin Receptor Antagonists, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67dee48dc49baa60fe2b41d5127f1512Test
https://pubmed.ncbi.nlm.nih.gov/34330170Test