المؤلفون: Minhye Chang, Sung-Ae Cho, Tae-Yun Sung, Seok-Jin Lee, Choon-Kyu Cho

المصدر: Anesthesia and Pain Medicine. 17:157-164

مصطلحات موضوعية: medicine.medical_specialty, business.industry, medicine.drug_class, Urinary system, Retrospective cohort study, General Medicine, Surgery, Desflurane, Anesthesia, Anesthetic, Heart rate, medicine, Antiemetic, medicine.symptom, business, Adverse effect, Postoperative nausea and vomiting, medicine.drug

الوصف: Background: The presence of a urinary catheter, postoperative pain, and postoperative nausea and vomiting are risk factors for emergence agitation (EA). Antimuscarinic agents have been the primary agents used for urinary catheter-related bladder discomfort prevention and treatment. Chlorpheniramine has antimuscarinic, antinociceptive, and antiemetic effects. This retrospective study investigated the effect of chlorpheniramine on EA prevention in patients following ureteroscopic stone surgery. Methods: Of 110 adult patients who underwent ureteroscopic stone surgery under general anesthesia between January and December 2019, the medical records of 93 patients were analyzed retrospectively. The patients were divided into control (n = 52) and chlorpheniramine (n = 41) groups according to they receipt of intravenous chlorpheniramine before the induction of anesthesia. The incidence and severity of EA were compared between the groups as primary and secondary endpoints, respectively. The effects of chlorpheniramine on the requirement for inhalation anesthetic (desflurane) during surgery, changes in mean blood pressure and heart rate during emergence, and adverse events were also compared. Results: The incidence (21.2% in the control group, 24.4% in the chlorpheniramine group) and severity of EA did not differ between groups. The intraoperative requirement for desflurane, changes in mean blood pressure and heart rate during emergence, and adverse events were also similar between groups. Conclusion: Chlorpheniramine did not affect EA in patients after ureteroscopic stone surgery.Trial registration: CRiS Registration number KCT0004879. Initial registration date was 3 April 2020 (Retrospectively registered).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afe33a6a87f5747300da116677d3ae5Test
https://doi.org/10.17085/apm.21066Test

المؤلفون: Minhye Change, Seok-Jin Lee, Tae-Yun Sung, Choon-Kyu Cho

المصدر: International Journal of Medical Sciences

مصطلحات موضوعية: Male, medicine.medical_specialty, rocuronium, Peak inspiratory pressure, law.invention, Fentanyl, surgery, Randomized controlled trial, law, Intubation, Intratracheal, Medicine, Humans, Orthopedic Procedures, Prospective Studies, Rocuronium, Aged, 80 and over, business.industry, Hand surgery, General Medicine, Hand, aged, Anesthesia, Orthopedic surgery, Anesthetic, Breathing, Neuromuscular Blockade, Female, Neuromuscular Blocking Agents, business, medicine.drug, Research Paper

الوصف: Background: The effects of neuromuscular blocking agents on the clinical performance of supraglottic airway devices and surgical condition in elderly patients undergoing hand surgery have not been established. We evaluated the effects of rocuronium on the clinical performance of an i-gel® supraglottic device and surgical condition in elderly patients undergoing orthopedic hand surgery. Methods: Patients aged 65-85 years were randomized to receive either rocuronium (rocuronium group) or saline (control group). We compared the rates of successful insertion of the i-gel on the first attempt as a primary outcome and also assessed the adequacy of i-gel maintenance during controlled ventilation, anesthetic requirement, surgical condition, and recovery time. Results: The rates of successful insertion of the i-gel on a first attempt were 93.1% in the rocuronium group versus 82.1% in the control group (P = 0.423). Peak inspiratory pressure (PIP) was lower in the rocuronium group than in the control group (15.2 vs. 17.9 cmH2O, respectively, P = 0.028). Spontaneous breathing was less common in the rocuronium group (24.1% vs. 57.1%, respectively, P = 0.011). The requirement of additional fentanyl to suppress spontaneous breathing or patient movement was less in the rocuronium group than in the control group (24.1% vs. 50.0%, respectively, P = 0.043). Surgical condition did not differ between the two groups. Recovery time was shorter in the rocuronium group than in the control group (8.4 vs. 9.9 min, respectively, P = 0.030). Conclusions: Rocuronium did not enhance the success rate of inserting the i-gel® or the surgical condition in elderly patients. However, using rocuronium reduced PIP, the frequency of spontaneous breathing, the requirement for additional fentanyl and patients' recovery time.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842646c88d8a478790f2a408ae10e867Test
http://europepmc.org/articles/PMC8100647Test

المؤلفون: Ji Yun Sung, Hong-Gu Joo

المصدر: Journal of the Preventive Veterinary Medicine. 45:13-17

مصطلحات موضوعية: chemistry.chemical_classification, Programmed cell death, Reactive oxygen species, Pharmacology, chemistry.chemical_compound, Paclitaxel, chemistry, Cell culture, Annexin, Fenbendazole, medicine, Propidium iodide, Fluorescein isothiocyanate, medicine.drug

الوصف: Fenbendazole (FBZ) is one of the safest anthelmintic drugs. FBZ has been found to have anti-cancer effects by destabilizing microtubules. In this study, a synergistic effect of paclitaxel (PA), a microtubule-stabilizing anti-cancer agent, and FBZ was investigated on HL-60 cells, a human leukemia cell line. The metabolic activity of cells significantly decreased and the nucleus morphology upon the treatment of FBZ and PA based on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assay and Hoechst 33342 staining, respectively. To investigate the involvement of reactive oxygen species (ROS), the metabolic activity of the cells after treatment of N-acetyl-L-cysteine (NAC) was measured. Indeed, NAC significantly increased the metabolic activity of the cells treated with FBZ and PA, suggesting that both drugs affect at least in part via ROS. Furthermore, FBZ and PA increased cell death in an annexin V- fluorescein isothiocyanate/propidium iodide staining assay. Taken together, FBZ and PA have a synergistic anti-cancer activity on HL-60 cells at a certain concentration. These results may provide researchers and clinicians in cancer-related fields with some valuable information to broaden the use of FBZ.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::97a3b5ba8e1f5c2153477723791a3c32Test
https://doi.org/10.13041/jpvm.2021.45.1.13Test

المؤلفون: Vanchiappan Aravindan, Palanichamy Sennu, Srinivasan Madhavi, Yun-Sung Lee

المصدر: ACS Nano. 14:10648-10654

مصطلحات موضوعية: Supercapacitor, Battery (electricity), Materials science, General Engineering, General Physics and Astronomy, 02 engineering and technology, Electrolyte, 010402 general chemistry, 021001 nanoscience & nanotechnology, Electrochemistry, 01 natural sciences, 0104 chemical sciences, law.invention, Capacitor, Chemical engineering, law, Electrode, medicine, General Materials Science, 0210 nano-technology, Mesoporous material, Activated carbon, medicine.drug

الوصف: We report the excellent charge storage performance of high-energy Li-ion capacitors (LIC) fabricated from the mesoporous Co3O4 nanosheets as the conversion-type battery component and Jack fruit (Artocarpus heterophyllus) derived activated carbon as a supercapacitor electrode, especially at high temperatures (50 and 40 °C). Prior to the fabrication, the electrochemical prelithiation strategy was applied to Co3O4 to alleviate the irreversibility and enrich the Li-ions for electrochemical reactions (Co0 + Li2O). The LIC delivered a maximum energy density of ∼118 Wh kg-1 at a high temperature of 50 °C. The significant difference is observed at a high rate of 2.6 kW kg-1 at 50 °C with excellent cycle stability up to 3000 cycles, with a retention of ∼87% compared with the LIC cycled at room temperature (∼74%). The magnificent electrochemical performance clearly demonstrates that the mesoporous structure and residual carbon synergistically facilitated the Li+/electron transport and hinder undesirable side reactions with electrolytes to realize high-energy density at high temperatures.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::8ab769bd46af68a4360695d17871c329Test
https://doi.org/10.1021/acsnano.0c04950Test

المؤلفون: Eun Yeong Nho, Jihyun Park, Dong-Sub Kim, Ji Young Suh, Nak-Yun Sung, Geon Kim, Sang-Yun Park, In-Jun Han, Ji Eom, Byung-Soo Lee

المصدر: Asian Journal of Beauty and Cosmetology. 18:235-247

مصطلحات موضوعية: Antioxidant, Chromatography, Chemistry, DPPH, Tyrosinase, medicine.medical_treatment, Elastase, General Medicine, Melanin, chemistry.chemical_compound, Collagenase, medicine, medicine.symptom, Cytotoxicity, Wrinkle, medicine.drug

الوصف: Purpose: In this study, we aim to study the functionality of multiple effects of peptide collagen and naturally derived compounds through in vitro experiments and human application tests. Method: Cytotoxicity of inner beauty film (IBF), pro-collagen generation ability, elastase and collagenase inhibition, DPPH radical scavenging and tyrosinase inhibition ability were measured, and skin improvement, through in vitro and human application test. Results: Cytotoxicity was not confirmed up to 1000 μg/mL. Elastase inhibition was 7.2% at a concentration of 125 μg/mL, and collagenase showed an inhibition rate of 16.3% at 31.3 μg/mL. The pro-collagen synthesis showed expression of 34%, compared with the negative control when the concentration was 62.5 μg/mL. The antioxidant activity of 250 μg/mL and whitening effect of 62.5 μg/mL are showed in the Results section, and there was no observed deformation or color change even after confirming the stability for 6 months. Even in the human clinical study, the wrinkle improvement before and after using the IBF was 32.2% at maximum, skin melanin and brown spot improvement was 32.5%, pore improvement was 31.5%, and skin density improvement was 12.8%, as shown in the Results section. Conclusion: Therefore, the IBF containing the complex of peptide collagen and naturally derived compounds has a positive effect on wrinkle improvement, skin melanin and brown spot improvement, skin pore improvement, and skin density improvement, as well as exhibiting antioxidant and whitening effects. As a result, IBF can be developed as a key material for cosmetics and foods.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::2b76446db6de5db3e6aadbe6331de10dTest
https://doi.org/10.20402/ajbc.2020.0028Test

المؤلفون: Eun-Ji Song, Na Rae Shin, Young-Do Nam, Han Seok Choi, Hee-Bok Kim, Dong-Woo Lim, Yun Sung Lim, Jing-Hua Wang, Hojun Kim, Shambhunath Bose

المصدر: The FASEB Journal. 34:8686-8701

مصطلحات موضوعية: Male, 0301 basic medicine, endocrine system, medicine.medical_specialty, endocrine system diseases, medicine.medical_treatment, Population, Thyroid Gland, Levothyroxine, Physiology, Biology, Prevotellaceae, Gut flora, Biochemistry, Rats, Sprague-Dawley, Feces, 03 medical and health sciences, 0302 clinical medicine, Hypothyroidism, RNA, Ribosomal, 16S, Internal medicine, Genetics, medicine, Animals, education, Molecular Biology, education.field_of_study, Bacteria, Bacteroidetes, business.industry, Microbiota, Thyroid, Thyroidectomy, biology.organism_classification, Gastrointestinal Microbiome, Rats, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Metagenomics, Propylthiouracil, Thyroid function, business, 030217 neurology & neurosurgery, Biotechnology, medicine.drug

الوصف: Background: The role of gut microbiota in metabolic diseases has recently been widely verified. Thyroid hormones are essential for the regulation of energy homeostasis and metabolic processes. However, the relationship between thyroid function and host gut microbial communities is not properly understood. Method: To determine whether and how gut microbiota is associated with thyroid function, metagenomics analysis of the bacterial population in fecal samples of rat models of hyperthyroidism (induced by levothyroxine) and hypothyroidism (induced by propylthiouracil or thyroidectomy) was conducted through 16SrRNA gene sequencing. Finding: Our results revealed that all thyroid dysfunction models were definitely established and gut microbial composition varied according to different thyroid functional status. The relative abundance of Ruminococcus was significantly higher in the hyperthyroidism group (HE) vs both the normal and hypothyroidism (HO) groups while S24-7 was significantly higher in the HO group compared to both the normal and HE groups. The relative abundance of Prevotellaceae and Prevotella were significantly lower in the HO group vs the normal. Firmicutes and Oscillospira was significantly higher in the SHO (surgery-induced hypothyroidism) group than the SHAM group, while Prevotellaceae andPrevotella showed lower abundance in the SHO group compared to the SHAM group. Interpretation: This is the first perspective study of the relationship between thyroid gland and gut microbiota using Next Generation Sequencing-based microbial identification technology. We demonstrated that thyroid status and function influenced the gut microbial composition, and the results presented here can be used as reference in future studies to identify potential mechanism(s) by which thyroid modulates gut microbial population. Funding Statement: This work was supported by a National Research Foundation (NRF) of Korea Grant funded by the Korean Government (NRF- 2019R1A2B5B01070365). This work was also supported by the Main Research Program (E0170602-02) of the Korea Food Research Institute (KFRI) funded by the Ministry of Science and ICT. Declaration of Interests: The authors declare no conflict of interest. Ethics Approval Statement: The animal experimental protocol was approved by the Institutional Animal Care and Use Committee of Dongguk University (approval no. 2015-08128) and all experiments were conducted in accordance with the Guide for the Care and Use of Laboratory Animals

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113e6a1904506b52f19bc83ba749b8daTest
https://doi.org/10.1096/fj.201903091rrTest

المؤلفون: Tae-Yun Sung, Sung-Ae Cho, Choon-Kyu Cho, Seok-Jin Lee, Duk-Kyung Kim

المصدر: Annals of Geriatric Medicine and Research, Vol 23, Iss 4, Pp 204-211 (2019)
Annals of geriatric medicine and research

مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, business.industry, geriatric assessment, Sedation, lcsh:R, lcsh:Medicine, Surgical procedures, anesthesia, lcsh:Geriatrics, dissent and disputes, lcsh:RC952-954.6, Age groups, Anesthetic, Orthopedic surgery, medicine, Original Article, Local anesthesia, Geriatrics and Gerontology, medicine.symptom, Adverse effect, business, Reporting system, medicine.drug

الوصف: Background Although the average age of patients undergoing surgical procedures or anesthesia is increasing, differences in anesthesia-related injuries among different age groups have been not reported. This study compared older and younger patients on the basis of disputes regarding anesthesia-related injuries referred to the Korean Society of Anesthesiologists (KSA). Methods We retrospectively analyzed disputes regarding anesthesia-related injuries referred to the KSA between 2009 and 2018. After excluding duplicates, incomplete data, local anesthesia cases, and patients aged ≤18 or 55–64 years, the subjects were divided into older (≥65 years) and younger (19–54 years) age groups. The parameters included in the KSA database were compared between these two groups. Results The 115 cases included in the study included 28 and 87 cases from the older and younger groups, respectively. The proportions of preventable cases of anesthesia-related adverse events differed significantly between the older (25%) and younger groups (48.3%). The most common medical disputes in the older group were related to general anesthesia, orthopedic surgery, local hospitals, and anesthesiologist, whereas those in the younger group were related to sedation, plastic surgery, local clinics, and non-anesthesiologists. Conclusion In addition to understanding the differences in anesthesia characteristics according to age group, it is also necessary to develop means for reducing preventable anesthesia-related adverse events. Furthermore, we must continue to register anesthesia-related disputes, and a voluntary reporting system should be established to prevent anesthesia-related accidents.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76776eb9ab3300918c7bb853daea691eTest
http://www.e-agmr.org/upload/pdf/agmr-19-0026.pdfTest

المؤلفون: Tae-Yun Sung, Hong Seuk Yang, Jae-Ho Lee, Ha Jung Kim, Jae Moon Choi, Yong Beom Kim, Jung Woo Han, Yong Seop Shin, Jin Sun Kim

المصدر: Anesthesia and Pain Medicine

مصطلحات موضوعية: Neuromuscular Blockade, business.industry, Neuromuscular Physiology and Pharmacology, Pyridostigmine bromide, General Medicine, Neuromuscular Blocking Agents, Neuromuscular monitoring, Vial, Sugammadex, Neostigmine, Pyridostigmine, Neuromuscular blocking agents, Clinical Research, Anesthesia, medicine, Rocuronium, business, medicine.drug

الوصف: Background Neuromuscular blocking agents (NMBAs) and neuromuscular monitoring in anesthetic management are integral for endotracheal intubation, better visualization of the surgical field, and prevention of residual neuromuscular blockade and pulmonary complications. Sugammadex is a drug that reduces risk of residual neuromuscular blockade, with more rapid recovery compared to anticholinesterase. The purpose of this study was to investigate current usage status of NMBAs and antagonist with neuromuscular monitoring, among anesthesiologists in Korea. Methods Anesthesiologists working in Korea were invited to participate in an online survey via email January 2-February 28, 2018. The questionnaire consisted of 45 items, including preferred NMBAs, antagonists, neuromuscular monitoring, and complications related to the use sugammadex. A total of 174 responses were analyzed. Results Rocuronium was a commonly used NMBA for endotracheal intubation (98%) of hospitals, and maintenance of anesthesia (83.3%) in of hospitals. Sugammadex, pyridostigmine, and neostigmine were used in 89.1%, 87.9%, and 45.4% of hospitals. Neuromuscular monitoring was employed in 79.3% of hospitals; however only 39.7% of hospitals used neuromuscular monitoring before antagonist administration. Usual dosage range of sugammadex was 2.1-4 mg/kg in 35.1% of hospitals, within 2 mg/kg in 34.5% of hospitals, and 1 vial regardless of body weight in 22.4% of hospitals. Sugammadexrelated complications were encountered by 14.9% of respondents. Conclusions This survey indicates several minor problems associated with the use of antagonists and neuromuscular monitoring. However, most anesthesiologists appear to have appropriate information regarding the usage of NMBAs and sugammadex.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfaa0068990b1f415cdf316b025f53aTest
http://europepmc.org/articles/PMC7713803Test

المؤلفون: Tae-Yun Sung, Choon-Kyu Cho, Gwan Woo Ku, Young Seok Jee, Sung-Ae Cho, Seok-Jin Lee, Inho Huh

المصدر: Korean Journal of Anesthesiology, Vol 75, Iss 1, Pp 71-78 (2022)

مصطلحات موضوعية: medicine.medical_treatment, Urinary Bladder, anesthesia, Urinary Catheters, Urinary catheterization, Dexamethasone, law.invention, Pacu, catheters, Emergence Delirium, Randomized controlled trial, law, Anesthesiology, medicine, Humans, RD78.3-87.3, Prospective Studies, Prospective cohort study, Saline, catheterization, Pain, Postoperative, biology, business.industry, Incidence (epidemiology), biology.organism_classification, Catheter, Anesthesiology and Pain Medicine, Anesthesia, incidence, business, medicine.drug

الوصف: Background: Catheter-related bladder discomfort (CRBD) is common in patients with a urinary catheter and is a risk factor for emergence agitation (EA). The mainstay of CRBD management is anticholinergics. Dexamethasone inhibits acetylcholine release. This study aimed to evaluate the effects of dexamethasone on postoperative CRBD and EA.Methods: In this prospective study, 90 patients undergoing urological surgery requiring urinary catheterization were allocated randomly to one of two groups (each n = 45). Before induction of anesthesia, the dexamethasone group received 10 mg (2 ml) of dexamethasone intravenously, while the control group received 2 ml of saline in the same manner. The incidence and severity of CRBD were assessed 0, 1, 2, and 6 h after the patient arrived in the post-anesthesia care unit (PACU) as the primary outcomes. The incidence and severity of EA were also compared during emergence and recovery from anesthesia as secondary outcomes.Results: The incidences of CRBD in the control group and dexamethasone group at 0, 1, 2, and 6 h postoperatively were 28.9% and 15.6%, 55.6% and 55.6%, 57.8% and 46.7%, and 53.3% and 51.1%, respectively. The incidence and severity of CRBD assessed at 0, 1, 2, and 6 h postoperatively did not show intergroup differences. The incidence and severity of EA in the operating room and PACU also showed no difference between the groups.Conclusions: Dexamethasone (10 mg) administered before induction of anesthesia did not further reduce the incidence or severity of CRBD or EA in patients undergoing urological surgery.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5253f68194972e552c852b9a07b5a3cTest
https://pubmed.ncbi.nlm.nih.gov/34551471Test

المؤلفون: Yeon Hee Lee, Ju Mi Kim, Sung Bok Lee, Jae Yun Sung, Jong-uk Lee

المصدر: BMC Complementary Medicine and Therapies
BMC Complementary Medicine and Therapies, Vol 21, Iss 1, Pp 1-4 (2021)

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Antifungal Agents, medicine.medical_treatment, 030106 microbiology, Acupuncture Therapy, Self Administration, Case Report, Undiagnosed Diseases, Other systems of medicine, 03 medical and health sciences, Diabetes mellitus, Candida albicans, Incision and drainage, medicine, Acupuncture, Humans, Abscess, Fluconazole, biology, business.industry, Facial abscess, Candidiasis, Type 2 Diabetes Mellitus, Middle Aged, medicine.disease, biology.organism_classification, Surgery, 030104 developmental biology, Diabetes Mellitus, Type 2, Complementary and alternative medicine, Fungal abscess, Drainage, Female, business, Surgical incision, RZ201-999, medicine.drug

الوصف: Background Facial abscess caused by Candida albicans infection is a rare condition even in immunocompromised patients, and only a few cases have been reported. To our knowledge, this is the first case of multiple facial candidal abscesses caused by self-administered acupuncture in an undiagnosed diabetes mellitus patient. Case presentation A 57-year-old woman who had self-acupuncture treatment 2 weeks previously, presented with a 1-week history of progressive left eyelid swelling, erythema, and pain. Despite the antibiotic treatment, the lesion progressed. Surgical incision and drainage was performed and Candida albicans was isolated from the obtained pus culture. The patient was diagnosed with type 2 diabetes mellitus based on a random serum glucose level of 350 mg/dl and 9.2% HbA1c. The abscess resolved after seven incision and drainage cycles and 4 weeks of intravenous fluconazole treatment with an appropriate control of diabetes mellitus. Conclusion Unusual organisms and underlying immunocompromised condition should be suspected in cases of recurrent abscess showing an inadequate response to antibiotic treatment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3f0f0a0f3bed4379d146568681b300Test
https://doi.org/10.1186/s12906-021-03343-wTest