نتائج البحث - "Michela Pasello"

1

A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy

المؤلفون: Roberta Mazzone, Piero Picci, Katia Scotlandi, Michela Pasello, Patrizia Nanni, Giordano Nicoletti, Maria Cristina Manara, Antonello Mai, Clara Guerzoni, Camilla Cristalli, Pier Luigi Lollini, Lorena Landuzzi, Sergio Valente, Giulia Stazi, Paola B. Arimondo, Clemens Zwergel

المساهمون: Istituto Ortopedico Rizzoli [Bologna, Italy], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Centre National de la Recherche Scientifique (CNRS), Department of Medicinal Chemistry and Technologies, Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], This work was funded by AIRC (IG 18451 to K. Scotlandi, IG 19162 to A. Mai), the Italian Ministry of Health (TRANSCAN_ project TORPEDO_ER-2015-23604059 to K. Scotlandi), Progetto Ateneo Sapienza (to A. Mai), PRIN 2016 (prot 20152TE5PK to A. Mai), and the NIH (R01GM114306 to A. Mai)., The authors thank Cristina Ghinelli for editing the manuscript., Manara, Maria Cristina, Valente, Sergio, Cristalli, Camilla, Nicoletti, Giordano, Landuzzi, Lorena, Zwergel, Clemen, Mazzone, Roberta, Stazi, Giulia, Arimondo, Paola B, Pasello, Michela, Guerzoni, Clara, Picci, Piero, Nanni, Patrizia, Lollini, Pier-Luigi, Mai, Antonello, Scotlandi, Katia

المصدر: Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, American Association for Cancer Research, 2018, 17 (9), pp.1881-1892. ⟨10.1158/1535-7163.MCT-17-0818⟩

مصطلحات موضوعية: 0301 basic medicine, Male, patient-derived xenograft (PDX), MESH: Osteosarcoma/genetics, MESH: Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Cellular differentiation, DNA Methyltransferase Inhibitor, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, chemotherapy, MESH: Mice, Knockout, 0302 clinical medicine, MESH: Osteosarcoma/drug therapy, Antineoplastic Combined Chemotherapy Protocols, MESH: Aminoquinolines/administration & dosage, MESH: Animals, MESH: Quinolines/chemistry, Enzyme Inhibitors, MESH: DNA (Cytosine-5-)-Methyltransferase 1/metabolism, Mice, Knockout, DNA methylation, Chemistry, 3. Good health, Tumor Burden, MESH: Benzamides/pharmacology, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Benzamides, oncology, Aminoquinolines, Quinolines, MESH: Cisplatin/administration & dosage, MESH: Bone Neoplasms/metabolism, Osteosarcoma, MESH: Doxorubicin/administration & dosage, epigenetic, MESH: Bone Neoplasms/genetics, medicine.drug, DNA (Cytosine-5-)-Methyltransferase 1, musculoskeletal diseases, MESH: Aminoquinolines/pharmacology, MESH: Cell Line, Tumor, DNA damage, MESH: Gene Expression Regulation, Neoplastic/drug effects, MESH: Tumor Burden/genetics, MESH: Xenograft Model Antitumor Assays, Bone Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, 03 medical and health sciences, Cell Line, Tumor, osteosarcoma, medicine, Animals, Humans, Doxorubicin, MESH: DNA (Cytosine-5-)-Methyltransferase 1/antagonists & inhibitors, MESH: Enzyme Inhibitors/chemistry, Cisplatin, MESH: Humans, Nucleoside inhibitor, medicine.disease, MESH: Enzyme Inhibitors/pharmacology, Xenograft Model Antitumor Assays, MESH: Male, MESH: Enzyme Inhibitors/administration & dosage, MESH: Bone Neoplasms/drug therapy, 030104 developmental biology, MESH: Osteosarcoma/metabolism, Cancer research, cancer research, MESH: DNA (Cytosine-5-)-Methyltransferase 1/genetics, MESH: Benzamides/administration & dosage, MESH: Tumor Burden/drug effects

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55d5482d55dc2ed43ad6818ec4cbf60Test
https://hal.archives-ouvertes.fr/hal-02383680Test

2

Irinotecan and temozolomide upfront and in relapsed Ewing sarcoma: A translational study on MGMT (O6-methylguanine–DNA methyltransferase) and ABCG2 (MGMTLiberati)

المساهمون: Palmerini, Emanuela, Pasello, Michela, Jones, Robin Lewi, Manara, Maria Cristina, Fagioli, Franca, Grignani, Giovanni, Longhi, Alessandra, Cesari, Marilena, Abate, Massimo Eraldo, Paioli, Anna, Setola, Elisabetta, Hakim, Rossella, D'Ambrosio, Lorenzo, Parra, Alessandro, Sebastian, Asaftei Dorin, Righi, Alberto, Morandi, Luca, Donati, Davide Maria, Ferrari, Stefano, Scotlandi, Katia

المصدر: Journal of Clinical Oncology. 38:e23564-e23564

مصطلحات موضوعية: Cancer Research, Temozolomide, O6-methylguanine, Abcg2, biology, business.industry, medicine.disease, DNA methyltransferase, Irinotecan, Oncology, medicine, Recurrent Ewing Sarcoma, Cancer research, biology.protein, Sarcoma, business, neoplasms, Ewing sarcoma, medicine.drug

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d7274810c6f7e0ac1e3b6f6a775eecTest
https://doi.org/10.1200/jco.2020.38.15_suppl.e23564Test

3

Does MGMT (O6-methylguanine–DNA methyltransferase) have a role in metastatic Ewing sarcoma (ES) patients (pts) undergoing temozolomide (TMZ) and irinotecan (IRI)?

المؤلفون: Franca Fagioli, Alessandra Longhi, Emanuela Palmerini, Asaftei sebastian Dorin, Marilena Cesari, Massimo Eraldo Abate, Giovanni Grignani, Emanuela Marchesi, Robin L. Jones, Michela Pasello, Lorenzo D'Ambrosio, Maria Cristina Manara, Alessandro Parra, Katia Scotlandi, Piero Picci, Anna Paioli, Stefano Ferrari

المساهمون: Emanuela Palmerini, Michela Pasello, Robin Lewis Jone, Maria Cristina Manara, Alessandro Parra, Piero Picci, Giovanni Grignani, Emanuela Marchesi, Marilena Cesari, Alessandra Longhi, Massimo Abate, Anna Paioli, Lorenzo D'Ambrosio, Franca Fagioli, Asaftei sebastian Dorin, Stefano Ferrari, Katia Scotlandi

المصدر: Journal of Clinical Oncology. 35:11030-11030

مصطلحات موضوعية: metastatic Ewing sarcoma, Cancer Research, Temozolomide, O6-methylguanine, business.industry, medicine.disease, DNA methyltransferase, digestive system diseases, Irinotecan, chemistry.chemical_compound, Oncology, Metastatic Ewing Sarcoma, chemistry, medicine, Cancer research, business, neoplasms, Gene, DNA, Glioblastoma, medicine.drug

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1ba64b57a3f74ef4d1ea7e9f02655aTest
https://doi.org/10.1200/jco.2017.35.15_suppl.11030Test

4

Overcoming Glutathione S-Transferase P1–Related Cisplatin Resistance in Osteosarcoma

المؤلفون: Piero Picci, Anna Maria Caccuri, Michela Pasello, Francesca Michelacci, Isabella Scionti, Claudia Maria Hattinger, Katia Scotlandi, Monia Zuntini, Massimo Serra

المصدر: Cancer Research. 68:6661-6668

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcccef02adf6dec90f480524d2cab5ddTest
https://doi.org/10.1158/0008-5472.can-07-5840Test

5

CD99 triggering in Ewing sarcoma delivers a lethal signal through p53 pathway reactivation and cooperates with doxorubicin

المؤلفون: Piero Picci, Diego Moricoli, Mario Terracciano, Mario P. Colombo, Claudia Chiodoni, Pier Luigi Lollini, Maurizio Cianfriglia, Mauro Magnani, Katia Scotlandi, Sabrina Dominici, Marika Sciandra, Clara Guerzoni, Valentina Fiori, Mara Gellini, Michela Pasello, Maria Cristina Manara, Pier Maria Fornasari, Giordano Nicoletti

المساهمون: Guerzoni, C., Fiori, V., Terracciano, M., Manara, M.C., Moricoli, D., Pasello, M., Sciandra, M., Nicoletti, G., Gellini, M., Dominici, S., Chiodoni, C., Fornasari, P.M., Lollini, P.-L., Colombo, M.P., Picci, P., Cianfriglia, M., Magnani, M., Scotlandi, K.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research. 21(1)