المؤلفون: Ichiro Shiojima, Kazuya Takehana, Kei Yoshioka, Koichiro Matsumura, Shun Morishita, Hiroki Takahashi, Naoki Taniguchi, Munemitsu Otagaki, Masahiko Takagi, Yoshihiro Yamamoto

المصدر: Heart and Vessels. 34:607-615

مصطلحات موضوعية: Male, medicine.medical_specialty, Time Factors, Acute decompensated heart failure, Tolvaptan, 030204 cardiovascular system & hematology, Patient Readmission, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, medicine, Humans, 030212 general & internal medicine, Aged, Heart Failure, Dose-Response Relationship, Drug, Proportional hazards model, business.industry, Incidence (epidemiology), Sodium, Hazard ratio, Stroke Volume, Prognosis, medicine.disease, Confidence interval, Cardiac surgery, Survival Rate, Heart failure, Acute Disease, Female, Cardiology and Cardiovascular Medicine, business, Antidiuretic Hormone Receptor Antagonists, Follow-Up Studies, medicine.drug

الوصف: Inconsistent results have been reported concerning the effect of tolvaptan treatment on long-term prognostic outcomes in patients with acute decompensated heart failure (ADHF) and data are limited on prognostic factors affecting this patient population. We investigated prognostic factors influencing long-term clinical outcomes in patients with ADHF treated with tolvaptan in a real-world setting. A total of 263 consecutive patients hospitalized for ADHF and treated with tolvaptan were retrospectively enrolled. The patients were stratified into those who developed the combined event of cardiac death or rehospitalization for worsening heart failure within 1 year (n = 108) and those who were free of this combined event within 1 year (n = 155). Adjusted multivariate Cox proportional hazards model revealed that change in serum sodium level between pre-treatment and 24 h after tolvaptan administration [hazard ratio (HR) 0.913, 95% confidence interval (CI) 0.841–0.989, p = 0.025] and the time taken for tolvaptan initiation from admission (HR 1.043, 95% CI 1.009–1.074, p = 0.015) were independent predictors of combined event occurrence within 1 year. Moreover, change in serum sodium level > 1 mEq/L between pre-treatment and 24 h after administration and initiation of tolvaptan

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba42d3f298e8ab353010c98bd862f3cTest
https://doi.org/10.1007/s00380-018-1290-6Test

المؤلفون: Atsushi Doi, Hiroaki Tatsumi, Yusuke Hayashi, Jun Kakihara, Kenichi Sugioka, Masahiko Takagi, Kohei Fujimoto, Minoru Yoshiyama

المصدر: Heart and Vessels. 32:1227-1235

مصطلحات موضوعية: Male, medicine.medical_specialty, Pyridones, medicine.medical_treatment, Activated clotting time, Catheter ablation, 030204 cardiovascular system & hematology, Dabigatran, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Rivaroxaban, Risk Factors, Edoxaban, Thromboembolism, Internal medicine, Atrial Fibrillation, medicine, Humans, 030212 general & internal medicine, Aged, medicine.diagnostic_test, Heparin, business.industry, Incidence, Anticoagulants, Atrial fibrillation, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Cardiac surgery, Cerebrovascular Disorders, Logistic Models, ROC Curve, chemistry, Anesthesia, Multivariate Analysis, Catheter Ablation, Cardiology, Pyrazoles, Female, Apixaban, Cardiology and Cardiovascular Medicine, business, medicine.drug

الوصف: There are few reports about the incidence and predictors of silent cerebral thromboembolic lesions (SCLs) after atrial fibrillation (AF) ablation in patients treated with direct oral anticoagulants (DOACs). The purpose of this study is to evaluate the incidence and predictors of SCLs after AF ablation with cerebral magnetic resonance imaging (C-MRI) in patients treated with DOACs. We enrolled 117 consecutive patients who underwent first AF ablation and received DOACs, including apixaban, dabigatran, edoxaban, and rivaroxaban. DOACs were discontinued after administration 24 h before the procedure, and restarted 6 h after the procedure. During the procedure, activated clotting time (ACT) was measured every 15 min, and intravenous heparin infusion was performed to maintain ACT at 300–350 s. All patients underwent C-MRI the day after the procedure. SCLs were detected in 28 patients (24%) after AF ablation. Age, female sex, the presence of persistent AF, left atrial volume, procedure time, radiofrequency energy, electrical cardioversion, and mean ACT showed no correlations with the incidence of SCLs. Multivariate analysis revealed independent predictors of SCLs were CHA2DS2VASc scores ≥3, left atrial appendage (LAA) emptying velocity ≤39 cm/s, and minimum ACT ≤260 s. Patients with both CHA2DS2VASc scores ≥3 and LAA flow velocity ≤39 cm/s had the highest incidence of SCLs 15 of 26 patients (58%). In patients treated with DOACs, CHA2DS2VASc score ≥3, minimum ACT ≤260 s, and LAA emptying velocity ≤39 cm/s were independent risk factors for the SCLs after AF ablation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ad1b8604c661d070bb4126a0044d77Test
https://doi.org/10.1007/s00380-017-0985-4Test

المؤلفون: Hiroaki Tatsumi, Atsushi Doi, Yusuke Hayashi, Minoru Yoshiyama, Masahiko Takagi, Jun Kakihara

المصدر: Heart and Vessels. 32:1151-1159

مصطلحات موضوعية: Male, Provocation test, Pilsicainide, 030204 cardiovascular system & hematology, Risk Assessment, QT interval, 03 medical and health sciences, QRS complex, 0302 clinical medicine, Risk Factors, medicine, Humans, 030212 general & internal medicine, Brugada Syndrome, Retrospective Studies, Brugada syndrome, business.industry, Area under the curve, Lidocaine, Middle Aged, medicine.disease, Signal-averaged electrocardiogram, ROC Curve, Anesthesia, Ventricular Fibrillation, Ventricular fibrillation, Electrocardiography, Ambulatory, Female, Cardiology and Cardiovascular Medicine, business, Anti-Arrhythmia Agents, medicine.drug

الوصف: Non-invasive risk stratification for ventricular fibrillation (VF) in Brugada syndrome (BrS) has not been fully evaluated. The aim of this study was to assess the utility of signal-averaged Holter electrocardiogram (Holter SAECG) and 12-lead Holter electrocardiogram (Holter ECG) after a pilsicainide provocation test for non-invasive risk stratification in BrS. We enrolled 30 consecutive patients with BrS [divided into 2 groups: the VF group, those with a previous history of VF (n = 10); and the non-VF group, those without a history of VF (n = 20)] and 10 control subjects without type 1 ECG. We evaluated late potentials [LP: filtered QRS (f-QRS), RMS40, and LAS40] on the Holter SAECG for 4 h after the pilsicainide provocation and in the same patients on another day without performing the pilsicainide provocation. Furthermore, we measured QRS duration and QTc interval in leads V2 and V5, and J amplitude in lead V2 on the Holter ECG after the pilsicainide provocation. On the Holter SAECG, the f-QRS at 1 h and LAS40 at 3 h after the pilsicainide provocation were significantly larger in the VF group than in the non-VF group (f-QRS at 1 h: 113.9 ± 8.9 vs. 104.9 ± 8 ms; p = 0.01, LAS40 at 3 h: 45.4 ± 5.9 vs. 35.5 ± 7.4 ms; p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015aeaa37ee136286a98bf34894a97c7Test
https://doi.org/10.1007/s00380-017-0973-8Test

المؤلفون: Atsushi Shibata, Atsushi Doi, Minoru Yoshiyama, Yoshiki Matsumura, Kenichi Sugioka, Akihisa Hanatani, Masahiko Takagi, Ryouko Kitada, Shinichi Iwata

المصدر: Heart and Vessels. 32:287-294

مصطلحات موضوعية: Male, medicine.medical_specialty, Tolvaptan, Urology, Renal function, 030204 cardiovascular system & hematology, Kidney, Kidney Function Tests, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Japan, Sodium Potassium Chloride Symporter Inhibitors, Randomized controlled trial, law, Internal medicine, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Aged, Aged, 80 and over, Heart Failure, Creatinine, business.industry, Body Weight, Sodium, Benzazepines, Middle Aged, medicine.disease, Cardiac surgery, Endocrinology, medicine.anatomical_structure, chemistry, Heart failure, Female, Cardiology and Cardiovascular Medicine, business, Antidiuretic Hormone Receptor Antagonists, medicine.drug

الوصف: In patients with congestive heart failure and renal dysfunction, high dose of diuretics are necessary to improve congestion, which may progress to renal dysfunction. We examined the efficacy of tolvaptan with reduction of loop diuretics to improve renal function in patients with congestive heart failure and renal dysfunction. We conducted a multicenter, prospective, randomized study in 44 patients with congestive heart failure and renal dysfunction (serum creatinine concentration ≥1.1 mg/dl) treated with conventional diuretics. Patients were randomly divided into two groups: tolvaptan (15 mg) with a fixed dose of diuretics or with reducing to a half-dose of diuretics for 7-14 consecutive days. We examined the change of urine volume, body weight, serum creatinine and electrolyte concentrations in each group. Both groups demonstrated significant urine volume increase (724 ± 176 ml/day in the fixed-dose group and 736 ± 114 ml/day in the half-dose group) and body weight reduction (1.6 ± 1.5 kg and 1.6 ± 1.9 kg, respectively) from baseline, with no differences between the two groups. Serum creatinine concentration was significantly increased in the fixed-dose group (from 1.60 ± 0.47 to 1.74 ± 0.66 mg/dl, p = 0.03) and decreased in the half-dose group (from 1.98 ± 0.91 to 1.91 ± 0.97 mg/dl, p = 0.10). So the mean changes in serum creatinine concentration from baseline significantly differed between the two groups (0.14 ± 0.08 mg/dl in the fixed-dose group and -0.07 ± 0.19 mg/dl in the half-dose group, p = 0.006). The administration of tolvaptan with reduction of loop diuretics was clinically effective to ameliorate congestion with improving renal function in patients with congestive heart failure and renal dysfunction.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9435de68acf6b87dc31f7adbcefd3234Test
https://doi.org/10.1007/s00380-016-0872-4Test

المؤلفون: Minoru Yoshiyama, Hiroaki Tatsumi, Yusuke Hayashi, Doi Atsushi, Jun Kakihara, Masahiko Takagi

مصطلحات موضوعية: Battery (electricity), medicine.medical_specialty, Lithium (medication), business.industry, medicine.medical_treatment, Early detection, 030204 cardiovascular system & hematology, Implantable cardioverter-defibrillator, Disease cluster, Icd therapy, Article, 03 medical and health sciences, 0302 clinical medicine, Battery voltage, Internal medicine, medicine, Cardiology, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business, Device failure, medicine.drug

الوصف: Device failure from unexpected battery depletion is uncommon but can be life-threatening. Lithium cluster formation at the cathode is a novel mechanism of sudden implantable cardioverter-defibrillator (ICD) battery depletion that was first reported in 2014. We report a rare case of a 78-year-old woman with an ICD battery failure due to lithium cluster formation. Although she had never received ICD therapy, the battery voltage had dropped from 2.9 V to 2.54 V (end of life) unexpectedly for only 2 days. The prevalence of this rare phenomenon was reported to be 0.004% in 2014. However, it had gone up to 0.21% in October 2016. Both device manufacturers and clinicians should be aware of this phenomenon, and remote monitoring systems and vibratory patient notifier alerts should be considered for early detection and early treatment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2474f7e97ea3b47a1c1909cdbfe72fd6Test
https://europepmc.org/articles/PMC6149615Test/

المؤلفون: Eiichiro Nakagawa, Keiko Maeda, Hiroaki Tatsumi, Masahiko Takagi, Minoru Yoshiyama

المصدر: Journal of Arrhythmia, Vol 30, Iss 3, Pp 150-156 (2014)

مصطلحات موضوعية: lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, Defibrillation, medicine.medical_treatment, Amiodarone, QT interval, Internal medicine, medicine, Repolarization, Sinus rhythm, cardiovascular diseases, Nifekalant hydrochloride, business.industry, medicine.disease, Ventricular tachyarrhythmia, Dispersion of repolarization, lcsh:RC666-701, Anesthesia, Shock (circulatory), Ventricular fibrillation, cardiovascular system, Cardiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business, medicine.drug

الوصف: Background: Although nifekalant hydrochloride (NIF) has been demonstrated to suppress ventricular tachyarrhythmias, especially electrical storms, the mechanism by which it does so is still unclear. We examined the effects of NIF on the spatial dispersion of repolarization (SDR) after implantable cardioverter-defibrillator (ICD) shock. Methods and Results: In 35 patients with oral amiodarone and β-blocker therapy, and an ICD, we recorded the 87-lead electrocardiogram during sinus rhythm (CONTROL-1 group) under general anesthesia, and just after the termination of induced ventricular fibrillation (VF) by ICD shock, with or without NIF administration. In all recordings, the corrected QT interval (QTc) was measured in each lead. The dispersion of QTc (QTc-D; maximum QTc minus minimum QTc) was also measured. Compared with that in the CONTROL-1 group, the QTc-D exhibited significant deterioration after ICD shock (61±14 and 90±19 ms1/2, respectively; p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51d6347ccfddc3106cf82f5e214ab51Test
https://doi.org/10.1016/j.joa.2013.05.009Test

المؤلفون: Naohiko Aihara, Masayasu Hiraoka, Yasuhiro Yokoyama, Kazutaka Aonuma, Yukio Sekiguchi, Masahiko Takagi

المصدر: EP Europace. 20:1226-1226

مصطلحات موضوعية: Drug, medicine.medical_specialty, business.industry, Epsilon wave, media_common.quotation_subject, 030204 cardiovascular system & hematology, 03 medical and health sciences, Ajmaline, 0302 clinical medicine, Physiology (medical), Internal medicine, Interim, Cardiology, Medicine, 030212 general & internal medicine, Risk factor, Cardiology and Cardiovascular Medicine, business, medicine.drug, media_common

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::2d0bb992be6f9e76948216a15df518f6Test
https://doi.org/10.1093/europace/euy108Test

المؤلفون: Takahiko Naruko, Masahiko Takagi, Eiichiro Nakagawa, Yukio Abe, Rhyshi Komatsu, Akira Itoh, Kazuo Haze

المصدر: Journal of Arrhythmia, Vol 28, Iss 4, Pp 232-234 (2012)

مصطلحات موضوعية: lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, medicine.medical_treatment, Catheter ablation, Ventricular tachycardia, Ventricular tachycardia circuit, QRS complex, Left ventricular mapping, Internal medicine, medicine, Palpitations, cardiovascular diseases, Left bundle branch block, business.industry, Right bundle branch block, medicine.disease, Trunk, lcsh:RC666-701, Anesthesia, Left main bundle branch, cardiovascular system, Cardiology, Verapamil, Verapamil-sensitive idiopathic left ventricular tachycardia, medicine.symptom, Cardiology and Cardiovascular Medicine, business, medicine.drug

الوصف: We report the case of a 19-year-old man with verapamil-sensitive idiopathic left ventricular tachycardia (ILVT), who had paroxysmal palpitations for 3 years. Programmed right atrial and ventricular stimulation easily induced ventricular tachycardia (VT) with QRS duration of 125ms, right bundle branch block pattern, and right inferior axis, which are characteristics of ILVT. Left ventricular endocardial mapping accidentally produced a complete left bundle branch block and provoked prolongation of the QRS duration of VT, which was 143ms. However, no changes occurred in the cycle length, inducibility, or maintenance of VT. The VT was eliminated successfully by catheter ablation at the pre-Purkinje potential (PP) recording site. These findings suggest that the main trunk of the left bundle branch is not a critical component of the re-entry circuit of ILVT.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b89ebed488aa7a3bb85ee139fa3dfaTest
https://doi.org/10.1016/j.joa.2011.12.001Test

المؤلفون: Atsushi Doi, Keiko Maeda, Masahiko Takagi, Kenji Shimeno, Hiroaki Tatsumi, Minoru Yoshiyama

المصدر: Journal of cardiovascular electrophysiology. 21(6)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Pilsicainide, Sudden death, Risk Assessment, QRS complex, Electrocardiography, Heart Conduction System, Physiology (medical), Internal medicine, medicine, Ventricular outflow tract, Humans, Brugada syndrome, Brugada Syndrome, Observer Variation, medicine.diagnostic_test, business.industry, Coronary Sinus, Lidocaine, Middle Aged, medicine.disease, Electrophysiology, medicine.anatomical_structure, Death, Sudden, Cardiac, Ventricle, Anesthesia, Ventricular fibrillation, Cardiology, Ventricular Function, Right, Female, Cardiology and Cardiovascular Medicine, business, Anti-Arrhythmia Agents, medicine.drug, Sodium Channel Blockers

الوصف: Conduction Delay as a Marker for Brugada Syndrome. Objectives: To evaluate the significance of conduction delay (CD) in the right ventricle (RV) in Brugada syndrome (BS) as a marker for risk stratification of sudden death. Methods: Twenty-five patients with BS (7 with documented ventricular fibrillation (VF), 8 with syncope, and 10 without symptoms) and 10 control subjects were paced from the RV apex using 8 beats of drive pacing and a single extra-stimulus. CDs in the right ventricular outflow tract (RVOT) (CD-RV) and in the lateral left ventricle (L-LV) (CD-LV), and the local electrogram durations at a single extra-stimulus in RVOT (D-RV) and L-LV (D-LV) were calculated. We also evaluated changes in 12-lead ECG parameters in 16 patients with BS after pilsicainide challenge test (Pilsicainide-test). Results: Maximal CD-RV and maximal D-RV were significantly larger than maximal CD-LV and maximal D-LV in BS (26 ± 10 and 105 ± 15 vs 20 ± 6 and 92 ± 15 ms, P < 0.05, respectively). Maximal CD-RV and maximal D-RV in patients with documented VF were the largest among the 3 groups. There was a significant positive correlation between maximal CD-RV or maximal D-RV and changes in QRS duration in leads V2 and V5 and in S wave duration in lead II and V5 after Pilsicainide-test (CD-RV; r = 0.54, 0.51, 0.56, and 0.53: D-RV; r = 0.55, 0.5, 0.57, and 0.53, P < 0.05, respectively). In control subjects, there were no significant differences. Conclusions: CD in RV was a useful marker for identifying high-risk patients with BS. CD in the RV, especially in the RVOT epicardium, may be related to arrhythmias in BS. (J Cardiovasc Electrophysiol, Vol. 21, pp. 688-696, June 2010)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34666baa47cb8dfca115d2c0d04b285Test
https://pubmed.ncbi.nlm.nih.gov/20050961Test

المؤلفون: Hiroaki Tatsumi, Minoru Yoshiyama, Masahiko Takagi, Eiichiro Nakagawa

المصدر: Circulation journal : official journal of the Japanese Circulation Society. 72(6)

مصطلحات موضوعية: Quinidine, Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Drug Resistance, Catheter ablation, Internal medicine, medicine, Secondary Prevention, Ventricular outflow tract, Humans, Sulfhydryl Compounds, Brugada syndrome, Brugada Syndrome, business.industry, General Medicine, Implantable cardioverter-defibrillator, medicine.disease, Ventricular Premature Complexes, Cilostazol, Discontinuation, Anesthesia, Ventricular fibrillation, Ventricular Fibrillation, Cardiology, Catheter Ablation, Cardiology and Cardiovascular Medicine, business, medicine.drug

الوصف: The case of a 41-year-old man with Brugada syndrome (BS) who suffered electrical storms (ES) of ventricular fibrillation (VF) is presented. Although intravenous infusion of isoproterenol (ISP) suppressed the VF occurrence, he consistently experienced recurrence of VF following discontinuation of ISP infusion. Quinidine and cilostazol were ineffective. An analysis of VF episodes on electrocardiogram monitoring revealed that the QRS morphology of the first beat of all VF episodes was identical to that of premature ventricular complexes (PVCs) with a left bundle branch-block morphology and inferior axis, which occurred repetitively before the episodes of VF and were recorded throughout the day. In addition, stored electrograms from the implantable cardioverter defibrillator showed that the first beat of all VF episodes had the same morphology. On electrophysiological study, the VF-triggering PVC was found to originate from the posterior portion of the right ventricular outflow tract area and their elimination, which was achieved with radiofrequency catheter ablation (RFCA), resulted in the suppression of ES. Although several other PVCs were still observed, the patient has been free of VF during the 29-month follow-up period. This case indicates that RFCA of VF-triggering PVCs may be useful in the treatment of drug-resistant ES in patients with BS.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba59956b6a85c6444c334a55e83457c8Test
https://pubmed.ncbi.nlm.nih.gov/18503235Test