يعرض 1 - 4 نتائج من 4 نتيجة بحث عن '"Hitoshi Azuma"', وقت الاستعلام: 1.47s تنقيح النتائج
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    المصدر: Neuroscience Letters. 119:15-18

    الوصف: The diurnal variations of pineal indoles in New-Zealand Black (NZB) mice and Wistar rats were determined by HPLC fluorometry. Pineal N-acetylserotonin (NAc5HT) in NZB mice showed a marked diurnal variation, but no melatonin (MLT) was detected at any time of day or night. The night-time increases of NAc5HT in NZB mice and MLT in Wistar rats were delayed about one hour in animals kept under illumination of high intensity (2000 lux) during the light period (12 h) compared with those in animals kept under illumination of low intensity (10 lux). These results suggest that the intensity of illumination during the light period affects the diurnal rhythms of pineal indoles in experimental animals.

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    المصدر: Japanese Journal of Pharmacology. 33:65

    الوصف: A new eburnamine derivative, RU 24722 (RU), is structurally resemblant to Vincamine and is known as a specific and reversible depletor of noradrenaline (NA) in rat brain (Euvrard and Boissier, 1981). We further investigated the effect of RU on turnover of mouse brain monoamines and on catecholamine levels in rat plasma. NA levels in mouse brain were significantly decreased after 10mg/kg i.p. administration of RU with increasing MHPG, DOPAC and HVA. These changes returned to the control levels within 4 hrs. Levels of dopamine (DA), serotonin 5HIAA and histamine did not change at that dose. Vincamine did not affect those levels with the exception of a slight increase in MHPG levels at higher dose (50mg/kg). Plasma catecholamine levels in unanesthetized and freely-moving rats were 5- to 10-fold increased 10 min after RU (10mg/kg) and decreased to the basal levels within 4 hrs. These results indicate that RU increased turnover of NA and DA through releasing them from neural tissues.

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