نتائج البحث - "Agostina Nardone"

1

Targeting the Mevalonate Pathway to Overcome Acquired Anti-HER2 Treatment Resistance in Breast Cancer

المساهمون: Sethunath, Vidyalakshmi, Hu, Huizhong, DE ANGELIS, Carmine, Veeraraghavan, Jamunarani, Qin, Lanfang, Wang, Nichola, Simon, Lukas M, Wang, Tao, Fu, Xiaoyong, Nardone, Agostina, Pereira, Resel, Nanda, Sarmistha, Griffith, Obi L, Tsimelzon, Anna, Shaw, Chad, Chamness, Gary C, Reis-Filho, Jorge S, Weigelt, Britta, Heiser, Laura M, Hilsenbeck, Susan G, Huang, Shixia, Rimawi, Mothaffar F, Gray, Joe W, Osborne, C Kent, Schiff, Rachel

المصدر: Mol Cancer Res
Mol. Cancer Res. 17, 2318-2330 (2019)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Geranylgeranyl pyrophosphate, Receptor, ErbB-2, Farnesyl pyrophosphate, Mevalonic Acid, Antineoplastic Agents, Apoptosis, Breast Neoplasms, Mechanistic Target of Rapamycin Complex 1, Lapatinib, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Survivin, Humans, Medicine, Phosphorylation, skin and connective tissue diseases, neoplasms, Molecular Biology, business.industry, Cell growth, Trastuzumab, 030104 developmental biology, Oncology, chemistry, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, Female, Mevalonate pathway, Growth inhibition, business, Signal Transduction, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47e32d952d195af7dec86930048dfc3Test
https://doi.org/10.1158/1541-7786.mcr-19-0756Test

2

The oral selective oestrogen receptor degrader (SERD) AZD9496 is comparable to fulvestrant in antagonising ER and circumventing endocrine resistance

المؤلفون: Agostina Nardone, Rachel Schiff, Henry Brown, Meghana V. Trivedi, Martin Shea, Mark Pilling, Jamunarani Veeraraghavan, Chandandeep Nagi, Rinath Jeselsohn, Carmine De Angelis, Oona Delpuech, Maria Letizia Cataldo, Tamika Mitchell, C. Kent Osborne, Mothaffar F. Rimawi, Hazel M. Weir, Gary C. Chamness, Xiaoyong Fu, Susan G. Hilsenbeck

المساهمون: Pilling, Mark [0000-0002-7446-6597], Apollo - University of Cambridge Repository, Nardone, A., Weir, H., Delpuech, O., Brown, H., De Angelis, C., Cataldo, M. L., Fu, X., Shea, M. J., Mitchell, T., Veeraraghavan, J., Nagi, C., Pilling, M., Rimawi, M. F., Trivedi, M., Hilsenbeck, S. G., Chamness, G. C., Jeselsohn, R., Osborne, C. K., Schiff, R.

المصدر: British Journal of Cancer

مصطلحات موضوعية: Cancer Research, Indoles, Neoplasms, Hormone-Dependent, Breast Neoplasms, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, MCF-7 Cell, 0302 clinical medicine, Breast cancer, Cinnamate, In vivo, medicine, Animals, Humans, Receptor, skin and connective tissue diseases, Fulvestrant, Cancer, Cell Proliferation, Estradiol, Animal, Cell growth, Estrogens, medicine.disease, Estrogen, Metastatic breast cancer, 3. Good health, Tamoxifen, Oncology, chemistry, Receptors, Estrogen, Indole, Cell culture, Cinnamates, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, MCF-7 Cells, Heterografts, Female, Growth inhibition, Heterograft, Breast Neoplasm, Human, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1307add3c66d5075ec69b579adb4aedTest
http://europepmc.org/articles/PMC6353941Test

3

Abstract PD8-03: A FOXA1/FRA1-centered transcriptional axis regulates interferon signaling in high FOXA1-associated endocrine-resistant and metastatic breast cancer

المؤلفون: Rinath Jeselsohn, Carmine De Angelis, Rachel Schiff, Mothaffar F. Rimawi, Sarmistha Nanda, Resel Pereira, Xiaoyong Fu, Agostina Nardone, Martin Shea, Lanfang Qin, Nikhil Wagle, Ofir Cohen, C. Kent Osborne

المصدر: Cancer Research. 81:PD8-03

مصطلحات موضوعية: Cancer Research, Oncology, business.industry, Interferon, Cancer research, Medicine, Endocrine system, FOXA1, business, medicine.disease, Metastatic breast cancer, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e5d2f0da284154e69eed6ec36611de8dTest
https://doi.org/10.1158/1538-7445.sabcs20-pd8-03Test

4

Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy

المساهمون: Giuliano, Mario, Hu, H, Wang, Yc, Fu, X, Nardone, Agostina, Herrera, S, Mao, S, Contreras, A, Gutierrez, C, Wang, T, Hilsenbeck, Sg, DE ANGELIS, Carmine, Wang, Nj, Heiser, Lm, Gray, Jw, Lopez Tarruella, S, Pavlick, Ac, Trivedi, Mv, Chamness, Gc, Chang, Jc, Osborne, Ck, Rimawi, Mf, Schiff, R.

المصدر: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, Time Factors, Antineoplastic Agents, Hormonal, Cell Survival, Receptor, ErbB-2, medicine.medical_treatment, Gene Expression, Estrogen receptor, Breast Neoplasms, Lapatinib, Article, Mice, Downregulation and upregulation, Cell Line, Tumor, Internal medicine, Animals, Humans, Medicine, Molecular Targeted Therapy, Epidermal growth factor receptor, skin and connective tissue diseases, neoplasms, Neoadjuvant therapy, biology, Fulvestrant, business.industry, Cancer, medicine.disease, Xenograft Model Antitumor Assays, Neoadjuvant Therapy, Disease Models, Animal, Endocrinology, Proto-Oncogene Proteins c-bcl-2, Receptors, Estrogen, Oncology, Drug Resistance, Neoplasm, Tumor progression, Quinazolines, Cancer research, biology.protein, Female, Receptors, Progesterone, business, Biomarkers, Signal Transduction, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b1598f486d1beb5e4551a1d1f12f3dTest
https://doi.org/10.1158/1078-0432.ccr-14-2728Test

5

Abstract B16: Mathematical modeling identifies optimum palbociclib dosing schedules for the treatment of estrogen receptor-positive (ER+) breast cancer patients

المؤلفون: C. Guarducci, Gabriella Cohen, Agostina Nardone, Myles Brown, Franziska Michor, Weihan Liu, Rinath Jeselsohn, Shayna Stein

المصدر: Cancer Research. 80:B16-B16

مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, Combination therapy, Fulvestrant, business.industry, Cancer, Palbociclib, medicine.disease, Clinical trial, chemistry.chemical_compound, Breast cancer, chemistry, Internal medicine, Medicine, Dosing, business, Abemaciclib, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e477fd0549d606fc96ed8ae6f6238c43Test
https://doi.org/10.1158/1538-7445.camodels2020-b16Test

6

Combination of fulvestrant and chemotherapy in ESR1 Y537S mutant breast cancer cells and potential synergy mechanism related to p53 wildtype

المؤلفون: Ma Wen, Nanlin Li, C. Guarducci, Avery S. Feit, Rinath Jeseslsohn, Gabriella Cohen, Francisco Hermida-Prado, Hongliang Wei, Myles Brown, Wenting Pan, Agostina Nardone

المصدر: Journal of Clinical Oncology. 38:1065-1065

مصطلحات موضوعية: Cancer Research, Chemotherapy, Fulvestrant, Mechanism (biology), business.industry, medicine.medical_treatment, Mutant, Wild type, medicine.disease, Breast cancer, Oncology, medicine, Cancer research, Endocrine system, business, Estrogen receptor alpha, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::815a31bb038416860d6bf7963387a5fdTest
https://doi.org/10.1200/jco.2020.38.15_suppl.1065Test

7

Abstract PD2-02: Activation of the EGFR/RAS/p42,44 MAPK axis as a convergent mechanism of resistance to CDK4/6 inhibitors in ER+ breast cancer

المؤلفون: Jamunarani Veeraraghavan, Resel Pereira, Jorge S. Reis-Filho, Britta Weigelt, Sarmistha Nanda, Lanfang Qin, Rinath Jeselsohn, Maria Letizia Cataldo, Vidyalakshmi Sethunath, Mothaffar F. Rimawi, Rachel Schiff, Xiaoyong Fu, Agostina Nardone, Carmine De Angelis, Kent Osborne

المصدر: Cancer Research. 80:PD2-02

مصطلحات موضوعية: MAPK/ERK pathway, Cancer Research, Chemistry, Cell growth, Palbociclib, medicine.disease_cause, Cyclin D1, Gefitinib, Oncology, Cancer research, medicine, KRAS, E2F, Clonogenic assay, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d58852ff5cc8ad873291f2d89d5dd689Test
https://doi.org/10.1158/1538-7445.sabcs19-pd2-02Test

8

Abstract GS2-01: High levels of interferon-response gene signatures are associated with de novo and acquired resistance to CDK4/6 inhibitors in ER+ breast cancer

المصدر: Cancer Research. 80:GS2-01

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::62707dc1c64c8977590881b9cb8aac63Test
https://doi.org/10.1158/1538-7445.sabcs19-gs2-01Test

9

HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer

المساهمون: Xu, X., De Angelis, C., Burke, K. A., Nardone, A., Hu, H., Qin, L., Veeraraghavan, J., Sethunath, V., Heiser, L. M., Wang, N., Ng, C. K. Y., Chen, E. S., Renwick, A., Wang, T., Nanda, S., Shea, M., Mitchell, T., Rajendran, M., Waters, I., Zabransky, D. J., Scott, K. L., Gutierrez, C., Nagi, C., Geyer, F. C., Chamness, G. C., Park, B. H., Shaw, C. A., Hilsenbeck, S. G., Rimawi, M. F., Gray, J. W., Weigelt, B., Reis-Filho, J. S., Osborne, C. K., Schiff, R.

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Xenograft Model Antitumor Assay, Receptor, ErbB-2, Afatinib, medicine.medical_treatment, Breast Neoplasms, Biology, Lapatinib, Antibodies, Monoclonal, Humanized, Article, Targeted therapy, 03 medical and health sciences, Mice, 0302 clinical medicine, Germline mutation, Breast cancer, Trastuzumab, Cell Line, Tumor, medicine, Animals, Humans, Molecular Targeted Therapy, skin and connective tissue diseases, Cell Proliferation, Animal, Cancer, Quinazoline, medicine.disease, Xenograft Model Antitumor Assays, 030104 developmental biology, Oncology, Receptors, Estrogen, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Immunology, Neratinib, Mutation, Cancer research, Quinazolines, Female, Breast Neoplasm, medicine.drug, Human, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb068280b301594f2965d31acd31789Test
https://europepmc.org/articles/PMC5762201Test/

10

An epigenomic approach to therapy for tamoxifen-resistant breast cancer

المؤلفون: Nicholas Mitsiades, Rainer B. Lanz, Cristian Coarfa, Chad J. Creighton, Zheng Zhang, Yongcheng Song, Xiaoyong Fu, Bert W. O'Malley, C. Kent Osborne, Qin Feng, Constantine S. Mitsiades, Bin He, Agostina Nardone, James E. Bradner, Martin Shea, Rachel Schiff, Lei Wang, Susan G. Hilsenbeck

المصدر: Cell Research

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c16f2d3cdf58d637fb10ef1da2be07Test
https://doi.org/10.1038/cr.2014.71Test

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