Long-Term Caffeine Intake Exerts Protective Effects on Intestinal Aging by Regulating Vitellogenesis and Mitochondrial Function in an Aged Caenorhabditis Elegans Model
| العنوان: | Long-Term Caffeine Intake Exerts Protective Effects on Intestinal Aging by Regulating Vitellogenesis and Mitochondrial Function in an Aged Caenorhabditis Elegans Model |
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| المؤلفون: | Yhong-Hee Shim, Hyemin Min, Esther Youn |
| المصدر: | Nutrients, Vol 13, Iss 2517, p 2517 (2021) Nutrients Volume 13 Issue 8 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Aging, intestinal aging, Antioxidant, medicine.medical_treatment, oxidative stress response, Caenorhabditis elegans, medicine.disease_cause, Article, Animals, Genetically Modified, 03 medical and health sciences, Vitellogenin, chemistry.chemical_compound, 0302 clinical medicine, mitochondrial function, Internal medicine, medicine, Animals, TX341-641, caffeine, Nutrition and Dietetics, biology, Nutrition. Foods and food supply, anti-aging, Autophagy, biology.organism_classification, Actins, Mitochondria, Intestines, Oxidative Stress, 030104 developmental biology, Endocrinology, chemistry, Models, Animal, biology.protein, Vitellogenesis, Caffeine, vitellogenesis, 030217 neurology & neurosurgery, Function (biology), Oxidative stress, Food Science |
| الوصف: | Caffeine, a methylxanthine derived from plants, is the most widely consumed ingredient in daily life. Therefore, it is necessary to investigate the effects of caffeine intake on essential biological activities. In this study, we attempted to determine the possible anti-aging effects of long-term caffeine intake in the intestine of an aged Caenorhabditis elegans model. We examined changes in intestinal integrity, production of vitellogenin (VIT), and mitochondrial function after caffeine intake. To evaluate intestinal aging, actin-5 (ACT-5) mislocalization, lumenal expansion, and intestinal colonization were examined after caffeine intake, and the levels of vitellogenesis as well as the mitochondrial activity were measured. We found that the long-term caffeine intake (10 mM) in the L4-stage worms at 25 °C for 3 days suppressed ACT-5 mislocalization. Furthermore, the level of autophagy, which is normally increased in aging animals, was significantly reduced in these animals, and their mitochondrial functions improved after caffeine intake. In addition, the caffeine-ingesting aging animals showed high resistance to oxidative stress and increased the expression of antioxidant proteins. Taken together, these findings reveal that caffeine may be a potential anti-aging agent that can suppress intestinal atrophy during the progression of intestinal aging. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbeb43066517244b63f4299f402e963Test https://www.mdpi.com/2072-6643/13/8/2517Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bcbeb43066517244b63f4299f402e963 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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