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المؤلفون: Yael P. Mosse, Courtney M. Smith, Krishna Suresh, Ravi Radhakrishnan, Abigail A Lemmon, Keshav Patil, Jin H. Park, Mark A. Lemmon, Earl Joseph Jordan
المصدر: Proceedings of the National Academy of Sciences of the United States of America
مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, alpha-Helical, driver mutations, Disease, Computational biology, Biology, Molecular Dynamics Simulation, medicine.disease_cause, kinase activation, Machine Learning, 03 medical and health sciences, 0302 clinical medicine, medicine, Anaplastic lymphoma kinase, Humans, Anaplastic Lymphoma Kinase, chemistry.chemical_classification, Mutation, Multidisciplinary, Kinase, Cancer, Biological Sciences, medicine.disease, molecular dynamics, Amino acid, focus formation assay, Enzyme Activation, Biophysics and Computational Biology, 030104 developmental biology, chemistry, Protein kinase domain, 030220 oncology & carcinogenesis, Target protein
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9199b12102cdd0e542ec239a708e35afTest
http://europepmc.org/articles/PMC7958353Test -
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المؤلفون: Eugene V. Koonin, Noam Auslander, Yuri I. Wolf
المصدر: Proceedings of the National Academy of Sciences of the United States of America
مصطلحات موضوعية: driver mutations, In silico, passenger mutations, Computational biology, Biology, medicine.disease_cause, Evolution, Molecular, Neoplasms, Databases, Genetic, Genetics, medicine, Humans, Computer Simulation, Gene, Sequence (medicine), Mutation, Multidisciplinary, Models, Genetic, Artificial neural network, Cancer, Biological Sciences, neural networks, medicine.disease, cancer progression, machine learning, Recurrent neural network, PNAS Plus, Tumor progression, Neural Networks, Computer, human activities, Algorithms
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e695ca23c7551821fa393e7261e29048Test
https://doi.org/10.1073/pnas.1901695116Test -
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المؤلفون: Claudia N. Spaan, Jarom Heijmans, Jan Koster, Ruben J. de Boer, Alyson W. MacInnes, Jacqueline Ludovicus Maria Vermeulen, Wouter L. Smit, Gijs R. van den Brink, Tânia Martins Garcia, Jan Paul Medema, Marco Lezzerini, Vanesa Muncan, Prashanthi Ramesh, Bartolomeus J. Meijer
المساهمون: Graduate School, Tytgat Institute for Liver and Intestinal Research, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Gastroenterology and Hepatology, CCA - Cancer biology and immunology, Laboratory for General Clinical Chemistry, Oncogenomics, Center of Experimental and Molecular Medicine, Radiotherapy, General Internal Medicine
المصدر: Proceedings of the National Academy of Sciences of the United States of America, 117(41), 25560-25570. National Academy of Sciences
Proc Natl Acad Sci U S Aمصطلحات موضوعية: Adenoma, Cell division, Mice, Transgenic, mTORC1, Mechanistic Target of Rapamycin Complex 1, Biology, medicine.disease_cause, Tissue Culture Techniques, Mice, medicine, Animals, Humans, Gene knockdown, Multidisciplinary, Carcinoma, EIF4E, Driver mutations, Translation (biology), Biological Sciences, Colorectal cancer, Cell biology, Intestines, Organoids, HEK293 Cells, Protein Biosynthesis, Mutation, Cancer cell, KRAS, Global translation, Colorectal Neoplasms, Protein synthesis, Reprogramming, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc285b42dbd5905f7bee76ae706c536Test
https://pure.amc.nl/en/publicationsTest/driver -mutations -of-the-adenomacarcinoma-sequence-govern-the-intestinal-epithelial-global-translational-capacity(b9887a9c-b0c1-49aa-bfe1-d01c5e5c2282).html -
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المؤلفون: Clare Fiala, Eleftherios P. Diamandis
المصدر: BMC Medicine
BMC Medicine, Vol 18, Iss 1, Pp 1-9 (2020)مصطلحات موضوعية: 0301 basic medicine, Adult, DNA Mutational Analysis, Normal tissue, lcsh:Medicine, Context (language use), Disease, Review, medicine.disease_cause, Normal tissues, 03 medical and health sciences, Young Adult, 0302 clinical medicine, medicine, Humans, Gene, Aged, Mutation, Circulating tumor DNA, business.industry, lcsh:R, Driver mutations, Cancer, General Medicine, Middle Aged, medicine.disease, 030104 developmental biology, The Hallmarks of Cancer, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, business, Mutations, Passenger mutations
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e5e26cfddf582179c94bbbc1336f44Test
http://europepmc.org/articles/PMC7594459Test -
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المؤلفون: Irene Vanni, Enrica Teresa Tanda, Bruna Dalmasso, Lorenza Pastorino, Virginia Andreotti, William Bruno, Andrea Boutros, Francesco Spagnolo, Paola Ghiorzo
المصدر: Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 7 (2020)مصطلحات موضوعية: 0301 basic medicine, Neuroblastoma RAS viral oncogene homolog, Mutation rate, driver mutations, medicine.medical_treatment, Disease, Review, Biology, medicine.disease_cause, Biochemistry, Genetics and Molecular Biology (miscellaneous), Biochemistry, Targeted therapy, 03 medical and health sciences, 0302 clinical medicine, medicine, melanoma, Molecular Biosciences, Gene, Molecular Biology, lcsh:QH301-705.5, non-BRAF mutation, Mutation, Genetic heterogeneity, Melanoma, medicine.disease, targeted therapy, 030104 developmental biology, lcsh:Biology (General), 030220 oncology & carcinogenesis, Cancer research, genetic, heterogeneity, WES, WGS
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963d6500283ca19c51304fc876c8998cTest
http://europepmc.org/articles/PMC7396525Test -
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المؤلفون: Hans Clevers, Ivana Bozic, Chay Paterson
المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research
المصدر: Paterson, C, Clevers, H & Bozic, I 2020, ' Mathematical model of colorectal cancer initiation ', Proceedings of the National Academy of Sciences, vol. 117, no. 34, pp. 20681-20688 . https://doi.org/10.1073/pnas.2003771117Test
Proceedings of the National Academy of Sciences of the United States of America, 117(34), 20681-20688. National Academy of Sciences
Proc Natl Acad Sci U S Aمصطلحات موضوعية: Mutation rate, Genes, APC, Carcinogenesis, Colorectal cancer, medicine.disease_cause, law.invention, Cancer evolution, Proto-Oncogene Proteins p21(ras), Proto-Oncogene Proteins p21(ras)/genetics, Genes, APC/physiology, Immune system, Theoretical, Mutation Rate, law, Models, Genotype, Medicine, Humans, p53/genetics, ras, Mutation, Multidisciplinary, Oncogene, business.industry, APC/physiology, Driver mutations, Cancer, Colonic Neoplasms/genetics, Oncogenes, Biological Sciences, Models, Theoretical, Genes, p53, medicine.disease, Colorectal Neoplasms/genetics, Genes, p53/genetics, Genes, ras, Stochastic model, Genes, Colonic Neoplasms, Cancer research, Disease Progression, Suppressor, Tumor Suppressor Protein p53/genetics, KRAS, Carcinogenesis/genetics, Tumor Suppressor Protein p53, Colorectal Neoplasms, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0be1b6f7a2a90b22b288ed47a748750Test
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المؤلفون: Yasemin Basbinar, Cumhur Gündüz, Ayca Aykut, Ceyda Aldag, Füsun Okçu Pelit, Umut Can Uzun, Fatma Nil Ertaş, Korcan Korba, Ozlem Goksel, Aslı Tetik Vardarlı, Caglar Celebi, Tuncay Göksel, Levent Pelit, Tugberk Nail Dizdas, Ertan Baysal, Haydar Karakus, Ali Veral, Femin Yalcin, Eda Tayfur
المساهمون: Ege Üniversitesi
مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Oncology, Adult, Male, exhaled breath condensate, medicine.medical_specialty, Lung Neoplasms, driver mutations, Concordance, Adenocarcinoma of Lung, medicine.disease_cause, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, PTEN, Humans, Exhaled breath condensate, Lung cancer, Molecular Biology, Aged, volatile biopsy, Lung, biology, business.industry, 010401 analytical chemistry, Amplicon, Middle Aged, medicine.disease, lung adenocarcinoma, 0104 chemical sciences, respiratory tract diseases, medicine.anatomical_structure, 030228 respiratory system, Breath Tests, Exhalation, Mutation, biology.protein, Adenocarcinoma, Female, KRAS, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fddc024fd3ae178654e1a9bd79427952Test
https://hdl.handle.net/11454/71128Test -
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المؤلفون: Phyu P. Aung, Jonathan L. Curry, Dzifa Y. Duose, Sri Krishna C. Arudra, Leomar Y. Ballester, Doina Ivan, Haider A. Mejbel, Carlos A. Torres-Cabala, Victor G. Prieto, Dinesh Pradhan, Michael T. Tetzlaff, Raja Luthra, Priyadharsini Nagarajan
المصدر: Cancers, Vol 11, Iss 11, p 1714 (2019)
Cancers
Volume 11
Issue 11مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Pathology, medicine.medical_specialty, driver mutations, Biology, medicine.disease_cause, lcsh:RC254-282, DNA sequencing, Article, 03 medical and health sciences, 0302 clinical medicine, tumor heterogeneity, medicine, melanoma, Neoplasm, Gene, Mutation, histophenotypic heterogeneity, Genetic heterogeneity, Melanoma, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 030104 developmental biology, Oncology, Tumor morphology, 030220 oncology & carcinogenesis, Immunohistochemistry, next-generation sequencing
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9656d65ef57d54663485da9aff6da058Test
https://www.mdpi.com/2072-6694/11/11/1714Test -
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المؤلفون: Karl Hartmann, Bernd Klosterhalfen, Felipe Crespo, Nikolaos Mitsimponas, Maria Mitsogianni, Aristoteles Giagounidis, Sabine Haase
المصدر: Case Reports in Oncology
Case Reports in Oncology, Vol 11, Iss 1, Pp 109-113 (2018)مصطلحات موضوعية: 0301 basic medicine, Lung adenocarcinoma, Case Report, medicine.disease_cause, lcsh:RC254-282, Hairy cell leukemia, 03 medical and health sciences, 0302 clinical medicine, Non-small cell lung cancer, medicine, BRAF-V600E mutation, Lung cancer, neoplasms, Mutation, Lung, business.industry, Driver mutations, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, digestive system diseases, BRAF V600E, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Concomitant, Cancer research, Adenocarcinoma, Non small cell, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4338c075b7febf42a5f0db89f807420fTest
http://europepmc.org/articles/PMC5869534Test -
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المؤلفون: Barani Kumar Rajendran, Chu-Xia Deng
المصدر: Oncotarget
مصطلحات موضوعية: 0301 basic medicine, driver mutations, Breast Neoplasms, Review, Tumor initiation, genetic mutations, medicine.disease_cause, Bioinformatics, Metastasis, 03 medical and health sciences, breast cancer, Breast cancer, medicine, Humans, breast cancer driver genes, Mutation, business.industry, cancer drivers, Computational Biology, Cancer, medicine.disease, Pathway analysis, 030104 developmental biology, Oncology, Female, business, Carcinogenesis, human activities, Human breast
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739c95d73610ff3d603576e70d0e73fdTest
https://doi.org/10.18632/oncotarget.17225Test