Impact of stroke volume on motor outcome in neonatal arterial ischemic stroke
| العنوان: | Impact of stroke volume on motor outcome in neonatal arterial ischemic stroke |
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| المؤلفون: | Andreas Wiedemann, Alexandre N. Datta, Sandra Bigi, Thomas Schmitt-Mechelke, Leonie Steiner, Gian Paolo Ramelli, Danielle Mercati, Manuela Pastore-Wapp, Mária Regényi, Mark T Mackay, Claudia Poloni, Nedelina Slavova, Annette Hackenberg, Maja Steinlin, Joel Victor Fluss, Olive Maier, Elmar Keller, Sebastian Grunt, Andrea Capone Mori, Regula Schmid, Jean-Pierre Marcoz, Christian Weisstanner |
| المصدر: | European Journal of Paediatric Neurology, Vol. 25 (2020) pp. 97-105 |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Cerebral Palsy/etiology/pathology, Cerebral palsy, Entire brain, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Internal medicine, Medicine, Pediatric stroke, Brain/diagnostic imaging/pathology, Humans, cardiovascular diseases, Child, Preschool, Stroke, ddc:618, business.industry, Cerebral Palsy, Stroke/complications/diagnostic imaging/pathology, Infant, Newborn, Infant, Brain, General Medicine, Stroke volume, medicine.disease, Newborn, Arterial Ischemic Stroke, Predictive value, Clinical neurology, Brain Ischemia/complications/diagnostic imaging/pathology, Diffusion Magnetic Resonance Imaging, Child, Preschool, Pediatrics, Perinatology and Child Health, Cardiology, Female, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | Background and objectives Neonatal arterial ischemic stroke (NAIS) can lead to long-term neurological consequences such as cerebral palsy (CP). The aim of this study was to evaluate the predictive value of acute diffusion-weighted imaging (DWI) for CP by analyzing stroke volume next to brain structure involvement. Methods We included 37 term-born infants with NAIS prospectively registered in a nationwide pediatric stroke registry. DWI was performed between 0 and 8 days (mean 3 days) after stroke manifestation. Participants were neurologically assessed at the age of 2 years. We calculated the stroke volume (in mm3) and the ratio of the stroke volume to the volume of the entire brain (relative stroke volume). The predictive value of the relative stroke volume was analyzed and an optimal threshold for classification of children with high- and low-rates of CP was calculated. Predictive value of brain structure involvements and the prevalence of CP in combinations of different brain structures was also assessed. Results Sixteen children (43.2%) developed CP. Relative stroke volume significantly predicted CP (p Conclusion In addition to determining the involvement of affected brain areas, the volumetric quantification of stroke volume allows accurate prediction of cerebral palsy in newborns with NAIS. |
| تدمد: | 1532-2130 1090-3798 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ef3b1c877989f7063a0cbb37819b79Test https://pubmed.ncbi.nlm.nih.gov/31740218Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....a2ef3b1c877989f7063a0cbb37819b79 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15322130 10903798 |
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