Long-term increase of insulin secretion in mice subjected to pregnancy and lactation
| العنوان: | Long-term increase of insulin secretion in mice subjected to pregnancy and lactation |
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| المؤلفون: | Silvana Bordin, Everardo M. Carneiro, Fabio Takeo Sato, Caio Jordão Teixeira, Jean Franciesco Vettorazzi, Gabriel Forato Anhê, Fabiola Sales Furtuoso, Isabel Gouveia Adabo, Julia Modesto Vicente, Junia Carolina Santos-Silva, Dailson Nogueira de Souza, Marco Aurélio Ramirez Vinolo |
| المصدر: | Endocrine Connections Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Endocrine Connections, Vol 9, Iss 4, Pp 299-308 (2020) |
| بيانات النشر: | Bioscientifica Ltd, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, endocrine system, insulin secretion, type 2 diabetes mellitus, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, lactation, lcsh:Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Lactation, Internal Medicine, medicine, Glucose homeostasis, Endocrine system, GLICOSE, Pregnancy, geography, lcsh:RC648-665, geography.geographical_feature_category, pancreatic islets, business.industry, Pancreatic islets, Research, Type 2 Diabetes Mellitus, medicine.disease, Islet, 030104 developmental biology, medicine.anatomical_structure, pregnancy, Pancreas, business |
| الوصف: | Purpose Observational studies show that longer breastfeeding periods reduce maternal risk of type 2 diabetes mellitus. However, it is currently unknown if the long-term benefits of breastfeeding for maternal glucose homeostasis are linked to changes in the endocrine pancreas. Methods We presently evaluated functional, morphological and molecular aspects of the endocrine pancreas of mice subjected to two sequential cycles of pregnancy and lactation (L21). Age-matched mice not allowed to breastfeed (L0) and virgin mice were used as controls. Results L21 mice exhibited increased tolerance and increased glucose-stimulated insulin secretion (GSIS) by isolated islets. Pancreatic islets of L21 mice did not present evident morphological changes to justify the increased GSIS. On the other hand, islets of L21 mice exhibited a reduction in Cavb3 and Kir6.2 expression with concordant increased intracellular Ca2+ levels after challenge with glucose. Conclusion Altogether, the present findings show the breastfeeding exerts long-term benefits for maternal endocrine pancreas by increasing intracellular Ca2+ levels and GSIS. |
| اللغة: | English |
| تدمد: | 2049-3614 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50dc30c729113981c18d2443fef0668Test http://europepmc.org/articles/PMC7159261Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d50dc30c729113981c18d2443fef0668 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20493614 |
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