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المؤلفون: Lukas Tamayo-Orrego, Samer Salameh, Grant W. Brown, Andrew P. Jackson, David Gallo, Sushmetha Mohan, Frédéric Racicot, Trang Hoang, Brandon Ho, Amandine Bemmo, Frédéric Charron
المساهمون: Université de Montréal. Faculté de médecine. Département de médecine
المصدر: Nature Cancer
Tamayo Orrego, L, Gallo, D, Racicot, F, Bemmo, A, Mohan, S, Ho, B, Salameh, S, Hoang, T, Jackson, A P, Brown, G W & Charron, F 2020, ' Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma ', nature cancer . https://doi.org/10.1038/s43018-020-0094-7Testمصطلحات موضوعية: DNA Replication, Cancer Research, animal structures, Carcinogenesis, Tumor initiation, Biology, medicine.disease_cause, Loss of heterozygosity, Mice, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Hedgehog Proteins, Homologous recombination, Sonic hedgehog, Cancer models, Cerebellar Neoplasms, Cancer, 030304 developmental biology, Medulloblastoma, 0303 health sciences, DNA replication, Origin firing, medicine.disease, Cell biology, CNS cancer, Oncology, PTCH1, embryonic structures, biology.protein, 030217 neurology & neurosurgery
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4d4c4af099fd7b9ffa5fbc117c5f4aTest
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المؤلفون: Frédéric Charron, Lukas Tamayo-Orrego
المصدر: F1000Research
مصطلحات موضوعية: tumor progression, Tumor initiation, Review, General Biochemistry, Genetics and Molecular Biology, law.invention, Metastasis, 03 medical and health sciences, Mice, 0302 clinical medicine, law, Cerebellum, medicine, Tumor Microenvironment, Animals, Humans, Hedgehog Proteins, General Pharmacology, Toxicology and Pharmaceutics, Sonic hedgehog, Cerebellar Neoplasms, neoplasms, 030304 developmental biology, Progenitor, Medulloblastoma, 0303 health sciences, Tumor microenvironment, General Immunology and Microbiology, biology, business.industry, General Medicine, Articles, medicine.disease, 3. Good health, nervous system diseases, stomatognathic diseases, Tumor progression, cell senescence, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Suppressor, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5755cf5c04b15270443ab6d7369e74dTest
https://pubmed.ncbi.nlm.nih.gov/31700613Test -
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المؤلفون: Frédéric Charron, Shannon M. Swikert, Lukas Tamayo-Orrego
المصدر: Cell Cycle
مصطلحات موضوعية: 0301 basic medicine, Senescence, Genome instability, preneoplasia, medicine.disease_cause, Loss of heterozygosity, sonic hedgehog, 03 medical and health sciences, Ptch1, medicine, Animals, Humans, Hedgehog Proteins, TP53, Sonic hedgehog, neoplasms, Molecular Biology, Cellular Senescence, Genetics, Medulloblastoma, Extra Views, biology, p53, Cell Biology, medicine.disease, Hedgehog signaling pathway, nervous system diseases, stomatognathic diseases, 030104 developmental biology, PTCH1, cell senescence, Mutation, Cancer research, biology.protein, Tumor Suppressor Protein p53, Carcinogenesis, Signal Transduction, Developmental Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5dc10099687a4223936d0c2abd20d41Test
https://doi.org/10.1080/15384101.2016.1189044Test -
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المؤلفون: Frédéric Charron, Sarah E. Millar, Andrew M. Overmiller, Julio C. Salas-Alanis, Molly R. Marous, Donna M. Brennan-Crispi, Felicia Cooper, Joya Sahu, Natalia A. Riobo-Del Galdo, Kathleen P. McGuinn, Ioanna Ch. Georgiou, Maxwell Frankfurter, Lukas Tamayo-Orrego, Mỹ G. Mahoney
المصدر: The Journal of investigative dermatology. 139(2)
مصطلحات موضوعية: 0301 basic medicine, STAT3 Transcription Factor, Skin Neoplasms, Mice, Transgenic, Dermatology, Biochemistry, Zinc Finger Protein GLI1, Article, 03 medical and health sciences, Paracrine signalling, Mice, 0302 clinical medicine, GLI1, Cell Line, Tumor, medicine, Animals, Humans, Basal cell carcinoma, Hedgehog Proteins, Gene Knock-In Techniques, Sonic hedgehog, Phosphorylation, Autocrine signalling, Molecular Biology, Hedgehog, Skin, Desmoglein 2, biology, integumentary system, Cadherin, Chemistry, Basal Cell Nevus Syndrome, Cell Biology, medicine.disease, Molecular biology, Hedgehog signaling pathway, Patched-1 Receptor, Disease Models, Animal, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7845adc461f95ef903a971c816e8faTest
https://pubmed.ncbi.nlm.nih.gov/30291846Test -
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المؤلفون: David Gallo, Lukas Tamayo-Orrego, Grant W. Brown, Frédéric Charron, Samer Salameh, Amandine Bemmo, Frédéric Racicot, Sushmetha Mohan
المصدر: Neuro-Oncology. 21:ii113-ii113
مصطلحات موضوعية: Genome instability, Cancer Research, Mutation, animal structures, biology, DNA damage, DNA replication, Cancer, PTCH1 Gene, medicine.disease_cause, medicine.disease, chemistry.chemical_compound, Oncology, chemistry, embryonic structures, Cancer research, medicine, biology.protein, Neurology (clinical), Sonic hedgehog, DNA, Medulloblastoma
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5715fcbf750a981dc2369e8270294e2Test
https://doi.org/10.1093/neuonc/noz036.204Test -
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المؤلفون: Frédéric Charron
المصدر: Developmental Cell. 43:655-656
مصطلحات موضوعية: 0301 basic medicine, Cerebellum, Brain tumor, mTORC1, Mechanistic Target of Rapamycin Complex 1, Biology, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Precursor cell, medicine, Humans, Hedgehog Proteins, Cerebellar Neoplasms, Molecular Biology, Hedgehog, Medulloblastoma, Translation (biology), Cell Biology, medicine.disease, Hedgehog signaling pathway, Cell biology, 030104 developmental biology, medicine.anatomical_structure, nervous system, biological phenomena, cell phenomena, and immunity, Signal Transduction, Developmental Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed60b6295e9a3bc4318bf7043f4a0a60Test
https://doi.org/10.1016/j.devcel.2017.12.008Test -
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المؤلفون: Lukas Tamayo-Orrego, Chia-Lun Wu, Frédéric Charron, Nicolas Bouchard, Patryk Skowron, Michael D. Taylor, Marc Remke, Ahmed Khedher, Shannon M. Swikert
المصدر: Cell Reports, Vol 14, Iss 12, Pp 2925-2937 (2016)
مصطلحات موضوعية: 0301 basic medicine, p53, p16ink4a, Somatic cell, Cell, Loss of Heterozygosity, Kaplan-Meier Estimate, Loss of heterozygosity, Mice, CDKN2A, Cerebellum, Sonic hedgehog, Promoter Regions, Genetic, lcsh:QH301-705.5, Cellular Senescence, biology, Brain Neoplasms, Immunohistochemistry, 3. Good health, Patched-1 Receptor, ptch1, medicine.anatomical_structure, Disease Progression, Senescence, endocrine system, Ultraviolet Rays, Mutation, Missense, preneoplasia, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, sonic hedgehog, medicine, Animals, Humans, Hedgehog Proteins, neoplasms, Cyclin-Dependent Kinase Inhibitor p16, Medulloblastoma, DNA Methylation, medicine.disease, Mice, Inbred C57BL, stomatognathic diseases, 030104 developmental biology, PTCH1, lcsh:Biology (General), Microscopy, Fluorescence, biology.protein, Cancer research, Tumor Suppressor Protein p53
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd7194d126dc1e65ccd00317cad60ecTest
https://pubmed.ncbi.nlm.nih.gov/26997276Test -
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المؤلفون: Molly R. Marous, Andrew M. Overmiller, D.M. Brennan-Crispi, Felicia Cooper, My G. Mahoney, Julio C. Salas-Alanis, N.A. Riobo-Del Galdo, Frédéric Charron, Kathleen P. McGuinn, Joya Sahu, Lukas Tamayo-Orrego, Sarah E. Millar
المصدر: Journal of Investigative Dermatology. 136:S14
مصطلحات موضوعية: Tumor microenvironment, business.industry, Cell Biology, Dermatology, medicine.disease, medicine.disease_cause, Biochemistry, Metastasis, Tumor progression, Cancer research, Medicine, Tumor promotion, Neoplastic transformation, Keratinocyte migration, Skin cancer, business, Carcinogenesis, Molecular Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::21dda6ade3394f1d284010ce81bdd4c4Test
https://doi.org/10.1016/j.jid.2016.02.104Test -
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المؤلفون: Michèl A.A.P. Willemsen, Mustafa Tekin, Nicolas Dupré, Masoud Shekarabi, Jean-Baptiste Rivière, Guy A. Rouleau, Frédéric Charron, Jürgen Horst, Gülhis Deda, M. M. Lippert, Adèle Salin-Cantegrel, Claudia Gaspar, Liliane Karemera, A. Krause, Jean-Yves Lapointe, R. Jarrar
المصدر: Neurology, 69, 13, pp. 1350-5
Neurology, 69, 1350-5مصطلحات موضوعية: Male, Genotype, Population, DNA Mutational Analysis, Inheritance Patterns, Biology, medicine.disease_cause, Nervous System Malformations, White People, Exon, Xenopus laevis, Mutant protein, medicine, Animals, Humans, Genetic Predisposition to Disease, Genetic Testing, Hereditary Sensory and Autonomic Neuropathies, education, Agenesis of the corpus callosum, Genetics, Mutation, education.field_of_study, Symporters, Haplotype, Cell Membrane, Wild type, Quebec, Exons, medicine.disease, Neuromuscular development and genetic disorders [UMCN 3.1], Pedigree, Haplotypes, Oocytes, Female, Neurology (clinical), Agenesis of Corpus Callosum, Hereditary motor and sensory neuropathy
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3cf2272099b52134969c4195b1b5d90Test
https://pubmed.ncbi.nlm.nih.gov/17893295Test -
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المؤلفون: Frédéric Charron, Michael D. Taylor, Luisa Izzi, Marc Remke, Martin Lévesque, Lukas Tamayo-Orrego, Frédéric Mille, Paul A. Northcott, Andrey Korshunov, Marcel Kool, Stefan M. Pfister, Nicolas Bouchard, Julie Cardin
المصدر: Developmental Cell. (1):34-47
مصطلحات موضوعية: Patched Receptors, animal structures, DNA damage, Receptors, Cell Surface, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Mice, 0302 clinical medicine, Downregulation and upregulation, Neural Stem Cells, medicine, Animals, Humans, Cyclin D1, Hedgehog Proteins, Sonic hedgehog, Receptor, Cerebellar Neoplasms, Molecular Biology, neoplasms, 030304 developmental biology, Cell Proliferation, Medulloblastoma, 0303 health sciences, biology, Cell growth, Cell Biology, medicine.disease, Up-Regulation, nervous system diseases, Mice, Inbred C57BL, Patched-1 Receptor, stomatognathic diseases, PTCH1, 030220 oncology & carcinogenesis, Immunoglobulin G, Immunology, embryonic structures, Cancer research, biology.protein, Signal transduction, Developmental Biology, DNA Damage, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8969d70879f11c9fbf71748ec6296268Test