المؤلفون: Brian Conkright, Ana Barac, Adil Alaoui, Yuriy Gusev, Krithika Bhuvaneshwar, Rebecca Torguson, Shahla Riazi, Federico M. Asch, Simina M. Boca, Subha Madhavan, Paula R. Pohlmann, Robert M. Johnson, Michael Harris

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Breast cancer, business.industry, Internal medicine, Informatics, medicine, business, medicine.disease

الوصف: Background Cardiotoxicity is a serious adverse event associated with some of the most effective breast cancer therapies. Currently, it is difficult to predict which patients will develop cardiotoxicity due to the multiplicity of clinical, behavioral, and biological factors involved. MethodsHere we describe an effort to apply biomedical informatics approaches to patient data from MedStar Health’s EHR systems to discover and characterize factors that contribute to cardiotoxicity in a real world breast cancer population.ResultsData wrangling techniques including merging data from disparate clinical systems, data transformation, and de-identification of personal health information (PHI)were appliedto the raw clinical data to produce a structured integrated dataset for predictive analysis and hypothesis generation. Using this dataset as input, weshowed howpredictive models can be developed to identify patients at high risk for cardiotoxicity. ConclusionsWe demonstrate how suchmodels can be used for hypothesis generation and data exploration with the ultimate goal of developing applications for precision medicine.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::2d92552cce4cdf4a14427485a21ec647Test
https://doi.org/10.21203/rs.3.rs-34395/v1Test

المؤلفون: David Cueva, Erika M. Roberge, Miguel Roberts, Anas Belouali, Adil Alaoui, Bonnie L. Green, Mary Ann Dutton, Richard Amdur, Elizabeth Melnikoff, Janice L. Krupnick

المصدر: Psychological Trauma: Theory, Research, Practice, and Policy. 9:461-470

مصطلحات موضوعية: Adult, Male, 050103 clinical psychology, medicine.medical_specialty, Telemedicine, Social Psychology, Writing, medicine.medical_treatment, MEDLINE, Pilot Projects, PsycINFO, Stress Disorders, Post-Traumatic, Occupational Stress, 03 medical and health sciences, 0302 clinical medicine, Intervention (counseling), Humans, Medicine, 0501 psychology and cognitive sciences, Psychiatry, Iraq War, 2003-2011, Veterans Affairs, Qualitative Research, Veterans, Internet, Afghan Campaign 2001, business.industry, 05 social sciences, Middle Aged, medicine.disease, United States, 030227 psychiatry, Psychotherapy, Clinical trial, United States Department of Veterans Affairs, Clinical Psychology, Treatment Outcome, Therapy, Computer-Assisted, Cognitive therapy, Feasibility Studies, Female, business, Psychological trauma

الوصف: [Correction Notice: An Erratum for this article was reported in Vol 9(4) of Psychological Trauma: Theory, Research, Practice, and Policy (see record 2016-54154-001). In the article, the names of authors Adil Alaoui and Anas Belouali were misspelled as Adil Aloui and Anas Beloui respectively. All versions of this article have been corrected.] Objective: Veterans suffering from posttraumatic stress disorder (PTSD) may avoid or fail to follow through with a full course of face-to-face mental health treatment for a variety of reasons. We conducted a pilot effectiveness trial of an online intervention for veterans with current PTSD to determine the feasibility, safety, and preliminary effectiveness of an online writing intervention (i.e., Warriors Internet Recovery & EDucation [WIRED]) as an adjunct to face-to-face psychotherapy. Method: Veterans (N = 34) who had served in Iraq or Afghanistan with current PTSD subsequent to deployment-related trauma were randomized to Veterans Affairs (VA) mental health treatment as usual (TAU) or to treatment as usual plus the online intervention (TAU + WIRED). All research participants were recruited from the Trauma Services Program, VA Medical Center, Washington, DC. They completed baseline assessments as well as assessments 12 weeks and 24 weeks after the baseline assessment. The online intervention consisted of therapist-guided writing, using principles of prolonged exposure and cognitive therapy. The intervention was adapted from an evidence-based treatment used in The Netherlands and Germany for individuals who had been exposed to nonmilitary traumas. Results: In addition to showing that the online intervention was both feasible to develop and implement, as well as being safe, the results showed preliminary evidence of the effectiveness of the TAU + WIRED intervention in this patient population, with particular evidence in reducing PTSD symptoms of hyperarousal. Conclusion: With minor modifications to enhance the therapeutic alliance, this intervention should be tested in a larger clinical trial to determine whether this method of online intervention might provide another alternative to face-to-face treatment for veterans with PTSD. (PsycINFO Database Record

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f552c67ef0ef65ec9942f4f25c59e01Test
https://doi.org/10.1037/tra0000176Test

المؤلفون: Michael Harris, Yuriy Gusev, Krithika Bhuvaneshwar, Anas Belouali, Robert Clarke, Louis M. Weiner, Subha Madhavan, Varun Singh, Lei Song, Adil Alaoui, Robert M. Johnson

المصدر: BMC Bioinformatics

مصطلحات موضوعية: 0301 basic medicine, Databases, Factual, Computer science, Somatic cell, Big data, computer.software_genre, Biochemistry, Transcriptome, 0302 clinical medicine, Structural Biology, Variant analysis, Neoplasms, Gene expression, Biomarker discovery, Oligonucleotide Array Sequence Analysis, education.field_of_study, Translational bioinformatics, Applied Mathematics, Genotype-phenotype integration, Precision medicine, 3. Good health, Computer Science Applications, Outcomes research, 030220 oncology & carcinogenesis, DNA microarray, Data integration, Omics technologies, Bioinformatics, Population, Translational research, Context (language use), DNA sequencing, 03 medical and health sciences, Next generation sequencing, medicine, Cloud computing, Humans, 1000 Genomes Project, education, Molecular Biology, Integrative bioinformatics, business.industry, Cancer, Computational Biology, medicine.disease, Omics, Data science, 030104 developmental biology, business, computer, Software

الوصف: Background G-DOC Plus is a data integration and bioinformatics platform that uses cloud computing and other advanced computational tools to handle a variety of biomedical BIG DATA including gene expression arrays, NGS and medical images so that they can be analyzed in the full context of other omics and clinical information. Results G-DOC Plus currently holds data from over 10,000 patients selected from private and public resources including Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA) and the recently added datasets from REpository for Molecular BRAin Neoplasia DaTa (REMBRANDT), caArray studies of lung and colon cancer, ImmPort and the 1000 genomes data sets. The system allows researchers to explore clinical-omic data one sample at a time, as a cohort of samples; or at the level of population, providing the user with a comprehensive view of the data. G-DOC Plus tools have been leveraged in cancer and non-cancer studies for hypothesis generation and validation; biomarker discovery and multi-omics analysis, to explore somatic mutations and cancer MRI images; as well as for training and graduate education in bioinformatics, data and computational sciences. Several of these use cases are described in this paper to demonstrate its multifaceted usability. Conclusion G-DOC Plus can be used to support a variety of user groups in multiple domains to enable hypothesis generation for precision medicine research. The long-term vision of G-DOC Plus is to extend this translational bioinformatics platform to stay current with emerging omics technologies and analysis methods to continue supporting novel hypothesis generation, analysis and validation for integrative biomedical research. By integrating several aspects of the disease and exposing various data elements, such as outpatient lab workup, pathology, radiology, current treatments, molecular signatures and expected outcomes over a web interface, G-DOC Plus will continue to strengthen precision medicine research. G-DOC Plus is available at: https://gdoc.georgetown.eduTest. Electronic supplementary material The online version of this article (doi:10.1186/s12859-016-1010-0) contains supplementary material, which is available to authorized users.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d8460d5c3185200141e77ada8da6e6Test
http://europepmc.org/articles/PMC4851789Test

المؤلفون: Ming-Jye Hu, Stephen Clement, Seong Ki Mun, Adil Alaoui, Karen E Smith, Betty A. Levine

المصدر: Diabetes Technology & Therapeutics. 6:828-835

مصطلحات موضوعية: Blood Glucose, Research design, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Monitoring ambulatory, Monitoring, Ambulatory, Endocrinology, Diabetes management, Diabetes mellitus, Materials Testing, medicine, Humans, Poorly controlled diabetes mellitus, Prospective Studies, Prospective cohort study, Intensive care medicine, Glycemic, Internet, business.industry, Patient Selection, food and beverages, medicine.disease, Surgery, Clinical trial, Medical Laboratory Technology, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Research Design, business, Computer-Assisted Instruction

الوصف: Web-based diabetes management can be used to provide frequent interactions between patients and providers and thus result in improved glycemic control.In a single-center, prospective feasibility study, 16 poorly controlled patients with either type 1 or 2 diabetes mellitus were enrolled to assess the impact of using MyCareTeam, a web-based diabetes management application, for diabetes management. Patients were asked to transfer their blood glucose data electronically, maintain exercise logs, and communicate with their provider via MyCareTeam. The provider gave clinical interventions to optimize blood glucose control and provided feedback via MyCareTeam. Diabetes, nutrition, and exercise information was also available via MyCareTeam.A significant reduction of over 2.22% points in hemoglobin A1C was seen for the total patient population. Differences between moderate/heavy users (n = 8) versus light/never users (n = 8) of MyCareTeam were evaluated for intergroup differences based upon utilization. Moderate/heavy users had a significant 6-month A1C reduction of 3.15 percentage points compared with a reduction of 1.28 percentage points in light/never users. Other secondary end points were improved as well, including systolic blood pressure, diastolic blood pressure, total cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides. However, as expected, body mass index levels increased because of aggressive diabetes management with insulin therapy.These results demonstrate a significant treatment effect from the MyCareTeam application. A larger randomized control trial is under way at the Boston Veterans Administration Healthcare System. If these results are confirmed as expected, then web-based diabetes management may prove to be the link to achieving target American Diabetes Association glycemic goals in patients with poorly controlled diabetes.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589e5a493a0edb2f08ea68e061eb26e6Test
https://doi.org/10.1089/dia.2004.6.828Test

المؤلفون: Howard J. Federoff, Kevin Cleary, Timothy R. Mhyre, Betty A. Levine, Dongkyu Kim, Adil Alaoui

المصدر: Medical Imaging 2010: Advanced PACS-based Imaging Informatics and Therapeutic Applications.

مصطلحات موضوعية: Traumatic brain injury, Systems biology, Bioinformatics, computer.software_genre, medicine.disease, Data science, Information science, Biomarker (cell), Systems medicine, Disparate system, Informatics, medicine, computer, Data integration

الوصف: Traumatic Brain Injury (TBI) is a problem of major medical and socioeconomic significance, although the pathogenesis of its sequelae is not completely understood. As part of a large, multi-center project to study mild and moderate TBI, a database and informatics system to integrate a wide-range of clinical, biological, and imaging data is being developed. This database constitutes a systems-based approach to TBI with the goals of developing and validating biomarker panels that might be used to diagnose brain injury, predict clinical outcome, and eventually develop improved therapeutics. This paper presents the architecture for an informatics system that stores the disparate data types and permits easy access to the data for analysis.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::2637ec820d20f06ffa4aceef93022bc4Test
https://doi.org/10.1117/12.846090Test

المؤلفون: Fang Maggie Fang, E.M. McAlinden, Pam Angelus, Tang Ming-Jye Hu, Betty A. Levine, J.C. Welsh, Adil Alaoui, Seong Ki Mun

المصدر: 1st Transdisciplinary Conference on Distributed Diagnosis and Home Healthcare, 2006. D2H2..

مصطلحات موضوعية: medicine.medical_specialty, Telemedicine, business.industry, Remote patient monitoring, Health outcomes, medicine.disease, Home automation, Heart failure, Health care, medicine, University medical, Medical emergency, Intensive care medicine, business, health care economics and organizations

الوصف: Home healthcare technologies can help patients maintain their independence, allow them to stay in their own homes, improve health outcomes, and reduce costs. Mindmy-Heart, a CMS-funded project at Georgetown University Medical Center, has successfully implemented multiple technologies, such as home monitoring devices and care management tools, to allow for in-home management of congestive heart failure

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::de74746e5e313280bb11d58268d530a1Test
https://doi.org/10.1109/ddhh.2006.1624790Test

المؤلفون: Vance Watson, Keith McCall, Minh Vo, Kevin Cleary, David Lindisch, Nikunj Patel, Adil Alaoui

المصدر: SPIE Proceedings.

مصطلحات موضوعية: Electronic data capture, business.industry, computer.software_genre, medicine.disease, Health informatics, Clinical trial, Centralized database, Workflow, Medicine, Electronic data, Medical history, Data mining, Medical emergency, business, computer, Mobile device

الوصف: This paper describes a system that uses electronic forms to collect patient and procedure data for clinical trials. During clinical trials, patients are typically required to provide background information such as demographics and medical history, as well as review and complete any consent forms. Physicians or their assistants then usually have additional forms for recording technical data from the procedure and for gathering follow-up information from patients after completion of the procedure. This approach can lead to substantial amounts of paperwork to collect and manage over the course of a clinical trial with a large patient base. By using e-forms instead, data can be transmitted to a single, centralized database, reducing the problem of managing paper forms. Additionally, the system can provide a means for relaying information from the database to the physician on his/her portable wireless device, such as to alert the physician when a patient has completed the pre-procedure forms and is ready to begin the procedure. This feature could improve the workflow in busy clinical practices. In the future, the system could be expanded so physicians could use their portable wireless device to pull up entire hospital records and view other pre-procedure data and patient images.© (2005) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c0dfb69c2cf3ea89c0e36d4900a6b0f9Test
https://doi.org/10.1117/12.593347Test

المؤلفون: Walid G. Tohme, D. Wilson, T.F. Choudhri, C.J. Riedel, Adil Alaoui, N. Khanafer, Seong Ki Mun

المصدر: Proceedings Pacific Medical Technology Symposium-PACMEDTek. Transcending Time, Distance and Structural Barriers (Cat. No.98EX211).

مصطلحات موضوعية: medicine.medical_specialty, Patient diagnosis, Telemedicine, business.industry, medicine, Observational study, Neurosurgery, Medical emergency, Perioperative, Clinical efficacy, medicine.disease, business, Surgery

الوصف: Despite the growing interest and use of telemedicine, few studies have examined the clinical efficacy and reliability of telemedicine, and none have looked specifically at the role of telemedicine in neurosurgery. This prospective, observational study evaluates the effectiveness of telemedicine in the management of perioperative neurosurgical patients. A PC based compressed video media-conferencing system with high-resolution image transmission and retrieval is used. All transmissions are via point-to-point integrated services data network (ISDN 3) at 384kbps. Patients are examined by an on-site physician and remotely by a second physician using telemedicine. Examination data, assessment and recommendations are recorded on a standardized data collection form. The results of a pilot study of ten patients are presented. Correlation between the on-site and remote examiner was 100% for the following parameters: mental status, cranial nerves, sensory examination and wound evaluation. Correlation between observers was 89% for reflexes and 80% for speech, motor, and gait abnormalities. Sensitivity for detection of neurological abnormalities using telemedicine was 86%. Assessment and management decisions were identical for the on-site and remote physicians. Telemedicine provides an effective means to evaluate and manage neurosurgical patients in the peri-operative period.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::be44405711cb5ab6552cd0164c9dcb38Test
https://doi.org/10.1109/pacmed.1998.767914Test

المؤلفون: Betty A. Levine, N. Khanafer, Jeffery Collmann, Walid G. Tohme, Saif S. Rathore, Seong Ki Mun, A. Al-Aama, M. Hofilena, James F. Winchester, Kevin A. Schulman, Adil Alaoui, N. Pania, Jeanine Warisse Turner, L. Hoffman

المصدر: Proceedings Pacific Medical Technology Symposium-PACMEDTek. Transcending Time, Distance and Structural Barriers (Cat. No.98EX211).

مصطلحات موضوعية: Telemedicine, Stethoscope, business.industry, Medical record, medicine.medical_treatment, computer.software_genre, medicine.disease, law.invention, Patient satisfaction, Quality of life (healthcare), Videoconferencing, law, Health care, Medicine, Medical emergency, business, computer, Dialysis

الوصف: More than 280,000 patients are treated by hemodialysis in the USA. The first-year annual adjusted mortality is very high and, in part, relates to the dose of the delivered dialysis (Kt/V). Using multimedia telemedicine, we have been following dialysis patients for over one year with a weekly "telemedicine visit" in addition to weekly physician visits, in an attempt to maintain compliance with the dialysis schedule, in addition to comprehensive medical consultation. Transmission is achieved with T1 lines from the clinic to the physician's office or home. The telemedicine session uses electronic patient folders containing relevant medical details, digitized X-rays, lab values, etc. We are able to achieve high-quality videoconferencing, capture still or video images, record remote stethoscope sounds, capture local or remote data and modify the medical record. Our goal is to increase the quantity of delivered dialysis and thereby improve quality of life and patient satisfaction, and reduce the costs of medical care, at the same time maintaining patient confidentiality. Appropriate measures to ensure data integrity and patient confidentiality have been integrated into the study. Questionnaires are also utilized to measure, on an ongoing basis, quality of life and patient satisfaction, while a weekly questionnaire captures any medical event taking place. The project is nearing completion, with subsequent data analysis to take place in the following six months. The system and procedures we have employed are accepted enthusiastically by patients and staff alike, and have aided in patient management.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1c092204b26ce88e8eb4ab87d7b3e096Test
https://doi.org/10.1109/pacmed.1998.767941Test

المؤلفون: Adil Alaoui, J. Collman, Seong Ki Mun, Stephen Clement, Betty A. Levine, N. Khanafer

المصدر: Proceedings Pacific Medical Technology Symposium-PACMEDTek. Transcending Time, Distance and Structural Barriers (Cat. No.98EX211).

مصطلحات موضوعية: Telemedicine, Patient physician communication, medicine.medical_specialty, business.industry, Remote patient monitoring, Insulin, medicine.medical_treatment, medicine.disease, Insulin dose, Diabetes mellitus, Personal computer, Life expectancy, Medicine, Medical emergency, business, Intensive care medicine

الوصف: The objective is to study the feasibility of remotely monitoring people with diabetes using low-cost technology. Using a personal computer, randomly chosen people with type I diabetes transmit their diabetes related data to their physician at Georgetown University Medical Center on a weekly basis where he analyzes it and contacts the patient every week to make safe adjustments to diet, exercise plan and insulin dose to prevent different kinds of diseases. Based on the data received the physician at the Endocrinology Department was able to early correct blood glucose levels for many patients enrolled in the program and prevent many possible clinical complications. This preliminary study indicates that tight monitoring people with diabetes and frequent patient physician communication and feedback utilizing a low-cost technology can significantly lower the risk of getting diseases and avoid costly short and long term hospitalizations and ER visits thus increase the quality of life and life expectancy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7f3ab99edd82bf89685ad51b186d9c87Test
https://doi.org/10.1109/pacmed.1998.769917Test