Efficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older
| العنوان: | Efficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older |
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| المؤلفون: | Cunningham, A. L., Lal, H., Kovac, M., Chlibek, R., Hwang, S. -J., Diez-Domingo, J., Godeaux, O., Levin, M. J., Mcelhaney, J. E., Puig-Barbera, J., Vanden Abeele, C., Vesikari, T., Watanabe, D., Zahaf, T., Ahonen, A., Athan, E., Barba-Gomez, J. F., Campora, L., De Looze, F., Downey, H. J., Ghesquiere, W., Gorfinkel, I., Korhonen, T., Leung, E., Mcneil, S. A., Oostvogels, L., Rombo, L., Smetana, J., Weckx, L., Yeo, W., Heineman, T. C., Athan, E, Cunningham, Al, de Looze, F, Eizenberg, P, Yeo, W, Avelino-Silva, Tj, Neto, Jl, Santos, Rr, Weckx, L, Zerbini, Ca, Gauthier, Js, Ghesquiere, W, Gorfinkel, I, Mcelhaney, Je, Mcneil, Sa, Toma, A, Chlibek, R, Smetana, J, Poder, A, Ahonen, A, Forsten, A, Karppa, T, Korhonen, T, Seppä, I, Vesikari, T, Esen, M, Schwarz, Tf, Leung, E, Desole, Mg, Icardi, G, Pellegrino, A, Staniscia, T, Volpi, A, Ikematsu, H, Watanabe, D, Choi, Ws, Barba-Gomez, Jf, Mascarenas de Los Santos, A, Tinoco, Jc, Brotons, C, Caso, C, Diez-Domingo, J, Narejos Perez, S, Puig-Barberà, J, Rodriguez de la Pinta ML, Berglund, J, Blom, Kb, Liu, B, Pauksens, K, Rombo, L, Hwang, Sj, Thompson, A, Andrews, C, Jackson Downey, H, Freedman, M, Levin, M, Arbi, Mb, Campora, L, Catteau, G, Curran, D, Godeaux, O, Heineman, Tc, Kovac, M, Lal, H, Marion, S, Oostvogels, L, Oujaa, M, Ravault, S, Abeele, Cv, Vastiau, I, Zahaf, T, Junqueira, T, Berndtsson Blom, K, Downey, H, Rodriguez, Ml, Zerbini, C, Heineman, T, Levin, Mj, Puig, J, Heineman, Tc. |
| المصدر: | NEW ENGLAND JOURNAL OF MEDICINE r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-FISABIO. Repositorio Institucional de Producción Científica instname |
| بيانات النشر: | Massachusetts Medical Society, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Risk, 0301 basic medicine, Subunit, medicine.medical_specialty, Herpes Zoster Vaccine, Neuralgia, Postherpetic, Kaplan-Meier Estimate, Placebo, Herpes Zoster, law.invention, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, Internal medicine, 80 and over, medicine, Humans, 030212 general & internal medicine, Aged, Aged, 80 and over, Vaccines, business.industry, Postherpetic neuralgia, General Medicine, Middle Aged, medicine.disease, Vaccine efficacy, Surgery, Clinical trial, 030104 developmental biology, Female, Vaccines, Subunit, Neuralgia, Zoster vaccine, Postherpetic, business, medicine.drug |
| الوصف: | BACKGROUND A trial involving adults 50 years of age or older (ZOE-50) showed that the herpes zoster subunit vaccine (HZ/su) containing recombinant varicella-zoster virus glycoprotein E and the AS01(B) adjuvant system was associated with a risk of herpes zoster that was 97.2% lower than that associated with placebo. A second trial was performed concurrently at the same sites and examined the safety and efficacy of HZ/su in adults 70 years of age or older (ZOE-70). METHODS This randomized, placebo-controlled, phase 3 trial was conducted in 18 countries and involved adults 70 years of age or older. Participants received two doses of HZ/su or placebo (assigned in a 1: 1 ratio) administered intramuscularly 2 months apart. Vaccine efficacy against herpes zoster and postherpetic neuralgia was assessed in participants from ZOE-70 and in participants pooled from ZOE-70 and ZOE-50. RESULTS In ZOE-70, 13,900 participants who could be evaluated (mean age, 75.6 years) received either HZ/su (6950 participants) or placebo (6950 participants). During a mean follow-up period of 3.7 years, herpes zoster occurred in 23 HZ/su recipients and in 223 placebo recipients (0.9 vs. 9.2 per 1000 person-years). Vaccine efficacy against herpes zoster was 89.8% (95% confidence interval [CI], 84.2 to 93.7; P |
| تدمد: | 1533-4406 0028-4793 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c5eb4a935f30b7d44aa75f7253a258Test https://doi.org/10.1056/nejmoa1603800Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f9c5eb4a935f30b7d44aa75f7253a258 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15334406 00284793 |
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