المؤلفون: Hsing-Yuan Li, Der-Shiun Wang, Pi-Chang Lee, Chieh-Mao Chuang, Wan-Fu Hsu, Fei-Yi Wu, Shyi-Jou Chen, Chih-Chien Wang, Shao-Wei Huang, Betau Hwang, Zen-Chung Weng

المصدر: Journal of the Chinese Medical Association. 85:364-368

مصطلحات موضوعية: medicine.medical_specialty, medicine.medical_treatment, Pulmonary insufficiency, Corrective surgery, Chest tube drainage, Pleural drainage, Humans, Medicine, Ventricular outflow tract, Prospective Studies, Child, Retrospective Studies, Tetralogy of Fallot, Mechanical ventilation, Pulmonary Valve, business.industry, Infant, General Medicine, Perioperative, medicine.disease, Surgery, Treatment Outcome, Chest Tubes, Drainage, business

الوصف: BACKGROUND Right ventricular outflow tract (RVOT) obstruction relief is one of the major procedures during the total correction of tetralogy of Fallot (TOF). Pulmonary insufficiency (PI) is usually inevitable after a transannular incision with a patch repair is performed. Therefore, some surgeons advocate to place a monocusp valve within the transannular patch (TAP) in order to decrease the severity of the PI. However, the monocusp valve seemed not be very effective in some patients who underwent the complete TOF repair. METHODS Patients who had the classic form of TOF between January 2009 and January 2017 and underwent the corrective surgery with a TAP by the same cardiovascular surgeon were identified for further analysis. Clinical information including demographics at operation, perioperative data, and postoperative outcome were collected retrospectively and compared between the group with and without a monocusp valve. RESULTS A total of 24 TOF cases were included in the final analysis, and 16 (66.7%) patients received a monocusp valve placement. The patients' characteristics before and during the surgery were similar between the two groups. The median duration of chest tube drainage after the total correction in the monocusp group was longer than those without the valve (p = 0.04). There was no difference in the immediate postoperative data, including the inflammation/infection status, the duration of mechanical ventilation, and the length of ICU and hospital stay. CONCLUSION Implantation of a monocusp valve during the total TOF correction using a TAP did not bring benefit to improve the immediate postoperative outcomes, especially the duration of the pleural drainage. Further study with a prospective design and a larger number of cases is needed.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc61328c4e0aa4c4b7280513c5b7156Test
https://doi.org/10.1097/jcma.0000000000000641Test

المؤلفون: Ming-Chang Kao, Wan-Fu Su, Yun-Chen Huang, Shao-Cheng Liu

المصدر: Neurosurgery. 84:1059-1064

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Vidian neurectomy, Cluster Headache, 03 medical and health sciences, 0302 clinical medicine, Refractory, Quality of life, medicine, Humans, Pain Management, Effective treatment, Adverse effect, business.industry, Cluster headache, Neurectomy, Middle Aged, medicine.disease, Denervation, Ganglion, Surgery, Treatment Outcome, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, Neurology (clinical), business, 030217 neurology & neurosurgery

الوصف: BACKGROUND Management of chronic cluster headache (CCH) remains a challenging endeavor, and the optimal surgical approach for medically refractory CCH remains controversial. OBJECTIVE To conduct a preliminary evaluation of the efficacy and safety of vidian neurectomy (VN) in patients with medically refractory CCH. METHODS Between March 2013 and December 2015, 9 CCH patients, all of whom had failed to respond to conservative therapy, underwent VN with a precise nerve cut and maximal preservation of the sphenopalatine ganglion. Data included demographic variables, cluster headache onset and duration, mean attack frequency, mean attack intensity, and pain disability index measures pre- and through 12-mo postsurgery. RESULTS Seven of the 9 cases (77.8%) showed immediate improvement. Improvement was delayed by 1 mo in 1 patient, after which the surgical effects of pain relief were maintained throughout the follow-up period. One patient (11.1%) did not improve after surgery. One year after VN, patients' mean attack frequency, mean attack intensity, and pain disability index decreased by 54.5%, 52.9%, and 56.4%, respectively. No patient experienced treatment-related side effects or complications. CONCLUSION VN is an effective treatment method for CCH patients. Precise Vidian nerve identification and maximal preservation of the sphenopalatine ganglion may achieve good surgical outcomes and dramatically improve quality of life among patients, without significant adverse events.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e963240b6d94c94d710388f849c9fcaTest
https://doi.org/10.1093/neuros/nyy136Test

المؤلفون: Liying He, Peiyu Chen, Yang Yang, Sitang Gong, Liang Chen, Yingcai Zhang, Jia Yao, Min Yang, Hui Li, Jun Zheng, Lanlan Geng, Wan-Fu Xu, Jianye Cai

المصدر: Cellular Physiology and Biochemistry, Vol 51, Iss 3, Pp 1237-1249 (2018)

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Physiology, Colorectal cancer, education, Predictive marker, Cochrane Library, lcsh:Physiology, Prognostic score, lcsh:Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Tumor stage, Humans, Medicine, lcsh:QD415-436, Proportional Hazards Models, lcsh:QP1-981, business.industry, Palliative Care, Hazard ratio, GPS/mGPS, medicine.disease, Prognosis, Survival Analysis, Confidence interval, Meta-analysis, Treatment Outcome, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Colorectal Neoplasms, business

الوصف: Background/Aims: Increasing evidence indicates that the systemic inflammatory response plays a vital role in carcinogenesis. The Glasgow Prognostic Score or modified Glasgow Prognostic Score (GPS/mGPS) is a novel inflammatory indicator which consists of CRP and albumin. Here, we performed a meta-analysis to evaluate the prognostic value of the GPS/ mGPS in patients with colorectal cancer (CRC) and to assess its consistency in different CRC therapies. Methods: The electronic databases PubMed, Embase, Scopus, Web of Science, and Cochrane Library were searched from inception through December 2017 for the association between the GPS/mGPS and clinical outcomes. Study characteristics and prognostic data were extracted from each relevant study. Overall survival (OS) and cancer-specific survival (CSS) were considered the primary outcomes, and hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated. The quality of each study was pooled using the random-effects Mantel-Haenszel model. Finally, subgroup analyses were performed to detect the heterogeneity of different CRC treatments. Results: Thirty-four studies, with a combined total of 8834 patients, were eligible for this meta-analysis. Data on OS and CSS were available in 23 and 22 studies, respectively. By comparing the prognostic values of different levels of the GPS in CRC patients, the summary HRs for OS and CSS were 2.18 (95% CI 1.83-2.60) and 1.82 (95% CI 1.57-2.11), respectively. According to the different tumor stages, the subgroup analyses were stratified by different treatments, including curative or palliative therapy. The results robustly confirmed the prognostic role of the GPS/mGPS. Conclusion: Our results suggest that the GPS/mGPS is a novel and effective prognostic indicator for the OS and CSS of patients with CRC.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a93e50013ec72ef8920b7e5e4a4abb6Test
https://www.karger.com/Article/FullText/495500Test

المؤلفون: Mao-Feng Zhong, Tianhong Zhang, Wan-Fu Lin, Yunxiang Tang, Jijun Wang, YanYan Wei

المصدر: Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports

مصطلحات موضوعية: medicine.medical_specialty, medicine.medical_treatment, lcsh:Medicine, Traditional Chinese medicine, Article, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Brief Psychiatric Rating Scale, Odds Ratio, medicine, Adjuvant therapy, Humans, Medicine, Chinese Traditional, lcsh:Science, Antipsychotic, Clinical Trials as Topic, Multidisciplinary, Positive and Negative Syndrome Scale, business.industry, lcsh:R, Publication bias, medicine.disease, 030227 psychiatry, Treatment Outcome, Schizophrenia, Meta-analysis, lcsh:Q, business, Publication Bias, 030217 neurology & neurosurgery, Antipsychotic Agents, Drugs, Chinese Herbal

الوصف: Although recent studies focused on traditional Chinese medicine (TCM) for the treatment of refractory schizophrenia have reported that it may be beneficial, there is still lack of convincing evidence and critical meta-analytic work regarding its effectiveness as an adjunctive therapy. Therefore, we performed a meta-analysis to investigate the effectiveness of TCM in combination with antipsychotics for refractory schizophrenia. Fourteen articles involving 1725 patients published as of December 2016 were included which compared antipsychotic therapies to either TCM alone, or TCM as an adjunctive therapy. TCM was observed to have beneficial effects on aspects of the Positive and Negative Syndrome Scale (PANSS) including total score changes and negative score changes, as well as clinical effects estimated with PANSS or the Brief Psychiatric Rating Scale (BPRS). The changes in extrapyramidal side effects (RSESE) scores from baseline to the end of the treatment period were similar in two groups of related trials. TCM was also reported to mitigate some anti-psychotic related side-effects and overall, TCM adjuvant therapy was generally safe and well tolerated. While, the results indicated the potential utility of TCM as an alternative adjunctive therapeutic for refractory schizophrenia treatment, there remains a need for further high-quality studies.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002940a0a3577c8a92185a2f267cdbb4Test
https://doi.org/10.1038/s41598-018-24547-0Test

المؤلفون: Li-ying Liu, Yang Chen, Chao Zhang, Min Yang, Peiyu Chen, Zhao-Hui Xu, Huiwen Li, Shunxian Cheng, Qiang Wu, Wan-Fu Xu, Hong-Li Wang, Lu Ren, Sitang Gong, Ding-You Li, Cui-Ping Liang, Lanlan Geng

المصدر: Gastroenterology Research and Practice
Gastroenterology Research and Practice, Vol 2018 (2018)

مصطلحات موضوعية: medicine.medical_specialty, Hepatology, Article Subject, business.industry, Treatment outcome, Gastroenterology, Mean age, medicine.disease, Long segment, Surgery, Balloon dilatation, 03 medical and health sciences, Stent placement, 0302 clinical medicine, Secondary outcome, 030220 oncology & carcinogenesis, Esophageal stricture, Long term outcomes, Medicine, lcsh:Diseases of the digestive system. Gastroenterology, 030211 gastroenterology & hepatology, lcsh:RC799-869, business, Research Article

الوصف: Caustic esophageal stricture (CES) in children still occurs frequently in developing countries. We aimed to evaluate the long-term outcomes of endoscopic balloon dilatation (EBD) in treating CES in children and the influencing factors associated with outcome. We retrospectively reviewed the data of all patients who had a diagnosis of CES and underwent EBD from August 1, 2005, to December 31, 2014. The primary outcome was EBD success, which was defined as the maintenance of dysphagia-free status for at least 12 months after the last EBD. The secondary outcome was to analyze influencing factors associated with EBD success. Forty-three patients were included for analysis (29 males; mean age at first dilatation 44 months with range 121 months). 26 (60.5%) patients had long segment (>2 cm) stricture. A total of 168 EBD procedures were performed. Twenty-six (60.5%) patients were considered EBD success. Seventeen (39.5%) patients failed EBD and required stent placement and/or surgery. Patients in the EBD success group had significantly shorter stricture segments when compared to the EBD failure group (t=2.398, P=0.018, OR=3.206, 95% OR: 1.228–8.371). Seven (4.4%) esophageal perforations occurred in 6 patients after EBD. Stents were placed in 5 patients, and gastric tube esophagoplasty was performed in 14 patients. In conclusion, 26 (60.5%) of 43 children with CES had EBD success. Length of stricture was the main influencing factor associated with EBD treatment outcome.

وصف الملف: text/xhtml

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8991c5b2f07cccf84d79e4f02780ac4Test

المؤلفون: Tung-Tsun Huang, Wan-Fu Su, Mei-Chen Yang, Yuan-Yung Lin, Wei-Sheng Tang, Shao-Cheng Liu

المصدر: Journal of Voice. 28:644-651

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Voice Quality, Laryngoscopy, Vocal Cords, Lateralization of brain function, Pulmonary function testing, Laryngoplasty, Speech and Hearing, Suture (anatomy), Surveys and Questionnaires, Humans, Medicine, Vocal cord paralysis, Aged, Retrospective Studies, Aged, 80 and over, Sutures, medicine.diagnostic_test, business.industry, Suture Techniques, Retrospective cohort study, Middle Aged, Airway obstruction, LPN and LVN, medicine.disease, Surgery, Treatment Outcome, medicine.anatomical_structure, Otorhinolaryngology, Anesthesia, Vocal folds, Female, business, Vocal Cord Paralysis, Follow-Up Studies

الوصف: Summary Objectives To introduce a simplified suture lateralization (SL) technique to treat patients with bilateral vocal fold paralysis (BVFP). Study Design A retrospective study of surgical procedures by manual chart review. Methods The proposed endoscopic SL procedure was used for 20 patients operated on for BVFP between 2007 and 2013, with three attempts to remove a tracheostomy tube and 17 attempts to resolve the dyspnea. An adjustment procedure was also used to correct any excessive lateralization according to the individual's clinical symptoms, such as intolerable aspiration after SL in elderly patients and excessive breathiness of voice in socially active patients. St George's respiratory questionnaire was used to subjectively evaluate the efficacy of lateralization of vocal folds. Pulmonary function test with flow-volume loop was used to objectively evaluate the improvement of BVFP-related upper airway obstruction after surgery. Phonatory ability tests were also used to evaluate the degree of deterioration of voice quality. Result Twenty patients underwent 22 episodes of SL. Two adjustment procedures were performed to correct excessive breathiness of voice or intolerable aspiration. Respiration was adequate in all 19 patients without artificial airways. Voice quality was socially acceptable in 19 of the patients and even equal to preoperative voice quality in 14 of them. Temporary mild aspiration occurred in 18 patients only in the first few days after the procedure. One decannulation failure and refusing adjustment procedure occurred in one elderly patient. All the patients were followed up for surgical outcomes for at least 9 and 33 months on average. Conclusion SL is a simple, reversible, and minimally invasive reconstructive procedure for patients with BVFP. Our study supported its applicability for selected patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7df9a506fd4717d61e05108e8dd8dfTest
https://doi.org/10.1016/j.jvoice.2013.12.012Test

المؤلفون: Chao-Jung Lin, Jin-Chin Lee, Wan-Fu Su, Yee-Min Jen, Chun-Jen Hsueh, Chun-Jung Juan, Hsin-Chien Chen

المصدر: Otolaryngology–Head and Neck Surgery. 130:388-390

مصطلحات موضوعية: Carotid Artery Diseases, Male, medicine.medical_specialty, Osteoradionecrosis, Antineoplastic Agents, Aneurysm, Ruptured, Humans, Medicine, Radiation Injuries, Base (exponentiation), Carotid Pseudoaneurysm, Skull Base, Radiotherapy, business.industry, Carcinoma, Nasopharyngeal Neoplasms, Middle Aged, medicine.disease, Combined Modality Therapy, Embolization, Therapeutic, Skull, Treatment Outcome, medicine.anatomical_structure, Otorhinolaryngology, Nasopharyngeal carcinoma, Surgery, Radiology, business, Aneurysm, False

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544b3e28ee6c68fd6d3fe647b345bb87Test
https://doi.org/10.1016/j.otohns.2003.08.010Test

المؤلفون: Chung-Ching Hung, Wan-Fu Su, Yu-Che Hsiao

المصدر: The Annals of otology, rhinology, and laryngology. 116(2)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Glottis, Adolescent, Laryngoscopy, Video Recording, Neurological disorder, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Muscle tension, Severity of illness, medicine, Psychogenic disease, Humans, Vocal cord paralysis, Stroboscopy, 030223 otorhinolaryngology, Aged, Retrospective Studies, Aged, 80 and over, Voice Disorders, medicine.diagnostic_test, business.industry, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Prognosis, Surgery, Otorhinolaryngologic Surgical Procedures, medicine.anatomical_structure, Treatment Outcome, Otorhinolaryngology, 030220 oncology & carcinogenesis, Anesthesia, Muscle Tonus, Female, business, Vocal Cord Paralysis, Follow-Up Studies

الوصف: Objectives: We performed a retrospective, longitudinal study to compare the prevalence of hyperkinetic laryngeal features before and after successful correction in patients with unilateral vocal cord paralysis (UVCP). Methods: Eighty-six patients with UVCP who had a successful surgical correction were enrolled. Preoperative and postoperative videolaryngostroboscopy images were analyzed, and the muscle tension patterns (MTPs) were rated according to the Morrison-Rammage classification. A 4-item glottal closure index was used for each patient on study entry and for 40 normal subjects as the control group. Results: There was no significant difference in MTP prevalence before (57%) and after (55%) surgical correction for UVCP. Although the glottal closure symptoms were tremendously improved through surgical medialization for UVCP, they persisted and were more prevalent than those in normal individuals. Conclusions: Persistence of MTPs after correction of UVCP may be due to intractable vocal habits or psychogenic factors.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de9655374766d6f321dca585c828133Test
https://pubmed.ncbi.nlm.nih.gov/17388236Test

المؤلفون: Yaw-Don Hsu, Hwa Sheng, Wan-Fu Su, Hsin-Chien Chen

المصدر: Journal of the American College of Surgeons. 204(1)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adolescent, Voice Quality, Electromyography, medicine, Paralysis, Recurrent laryngeal nerve, Humans, Thyroarytenoid muscle, Vocal cord paralysis, Aged, Retrospective Studies, medicine.diagnostic_test, Laryngoscopy, business.industry, Recurrent Laryngeal Nerve, Cricothyroid articulation, Recovery of Function, respiratory system, Middle Aged, medicine.disease, Surgery, medicine.anatomical_structure, Spinal Nerves, Treatment Outcome, Anesthesia, Nerve Transfer, Female, medicine.symptom, Larynx, business, Vocal Cord Paralysis, Reinnervation, Follow-Up Studies

الوصف: Background Ansa cervicalis (AC)–recurrent laryngeal nerve anastomosis (RLN) is usually not desirable for correction of paralytic dysphonia when it is difficult to find a viable distal stump of the recurrent laryngeal nerve. Nerve implantation of the thyroarytenoid muscle with the ansa cervicalis is a simple alternative method. Study design Ten patients with unilateral vocal cord paralysis were prospectively designed to receive nerve implantation. A minimum period of 12 months after onset of paralysis was allowed to elapse to permit possible spontaneous reinnervation or compensation. Patients were followed long enough (at least 2 years) to determine if the procedure was successful. All patients were subjected to preoperative and postoperative voice recording, acoustic analysis, and videolaryngoscopy. Some of them underwent laryngeal electromyography. Results Ten patients underwent nerve implantation of the thyroarytenoid muscles by using the ansa cervicalis, and 8 of 10 (80%) had improved phonatory quality. Laryngeal electromyography showed that the procedure produced satisfactory reinnervation of the thyroarytenoid muscle. Conclusions Nerve implantation of the thyroarytenoid muscle by the anso cervicalis is a simple and efficient alternative to nerve transfer if dense scarring at the cricothyroid articulation and lack of a viable distal stump of the recurrent laryngeal nerve preclude the procedure of nerve transfer. But careful selection of the appropriate candidate seems to be the earliest prerequisite for a successful procedure.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1643f255063aba169f7affdcf4af82fTest
https://pubmed.ncbi.nlm.nih.gov/17189114Test

المؤلفون: Qi-Xin Wang, Wan-Fu Zhu, Hui Zhuang, De-gui Sun, Min Yu, Li-Min Yin, Xiu-lan Tian, Lai Wei, Yan Gao, Xiaoyuan Xu, Wen-mei Fan, Yan-Bin Wang

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Viral Hepatitis, Biology, Gastroenterology, Liver Function Tests, Internal medicine, Genotype, medicine, Humans, Gene, 3' Untranslated Regions, Polymerase, Aged, Polymorphism, Genetic, medicine.diagnostic_test, Three prime untranslated region, Interleukin-12 Subunit p40, virus diseases, General Medicine, Hepatitis C, Middle Aged, medicine.disease, Virology, Interleukin-12, Real-time polymerase chain reaction, Treatment Outcome, Interleukin 12, biology.protein, Female, Liver function tests

الوصف: AIM: To investigate the effect of interleukin-12 p40 gene (IL12B) 3’-untranslated region polymorphism on the outcome of HCV infection. METHODS: A total of 133 patients who had been infected with HCV for 12-25 (18.2 ± 3.8) years, were enrolled in this study. Liver biochemical tests were performed with an automated analyzer and HCV RNA was detected by fluorogenic quantitative polymerase chain reaction. B-mode ultrasound was used for liver examination. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for the detection of IL12B (1188A/C) polymorphism. RESULTS: Self-limited infection was associated with AC genotype (OR = 3.48; P = 0.001) and persistent infection was associated with AA genotype (OR = 0.34; P = 0.014) at site 1188 of IL12B. In patients with persistent HCV infection, no significant differences were found regarding the age, gender, duration of infection and biochemical characteristics (P > 0.05). According to B-mode ultrasound imaging and clinical diagnosis, patients with persistent infection were divided into groups based on the severity of infection. No significant differences were found in the frequency of IL-12 genotype (1188A/C) between different groups (P > 0.05). CONCLUSION: The polymorphism of IL12B (1188A/C) appears to have some influence on the outcome of HCV infection.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77c1b94814eb8699d39338f321a6048Test
https://europepmc.org/articles/PMC4576283Test/