Utility of digital rectal examination in a population with prostate cancer treated with active surveillance
| العنوان: | Utility of digital rectal examination in a population with prostate cancer treated with active surveillance |
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| المؤلفون: | Marian S. Wettstein, Gregory J. Nason, Omar Alhunaidi, Neil Fleshner, Noelia Sanmamed-Salgado, Ants Toi, Khaled Ajib, Laurence Klotz, Guan Hee Tan, Thenappan Chandrasekar, Ardalan E. Ahmad, Hanan Goldberg, Jaime O. Herrera-Caceres, Dixon T.S. Woon |
| المصدر: | Canadian Urological Association journal = Journal de l'Association des urologues du Canada, vol 14, iss 9 Can Urol Assoc J |
| بيانات النشر: | Canadian Urological Association Journal, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Urologic Diseases, Aging, medicine.medical_specialty, Prostate biopsy, Urology, Clinical Sciences, Oncology and Carcinogenesis, Population, 030232 urology & nephrology, urologic and male genital diseases, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Primary outcome, Clinical Research, Internal medicine, medicine, education, Original Research, Cancer, screening and diagnosis, education.field_of_study, medicine.diagnostic_test, business.industry, Prostate Cancer, Prevention, Magnetic resonance imaging, Odds ratio, Rectal examination, Urology & Nephrology, medicine.disease, Predictive value, 4.1 Discovery and preclinical testing of markers and technologies, Detection, Oncology, 030220 oncology & carcinogenesis, business, 4.2 Evaluation of markers and technologies |
| الوصف: | Introduction: Digital rectal examination (DRE) is part of the clinical evaluation of men on active surveillance (AS). The purpose of the present study is to analyze the value of DRE as a predictor of upgrading in a population of men with prostate cancer (PCa) treated with AS. Methods: We used the prostate biopsy (PBx) database from an academic center, including PBx from 2006–2018, and identified 2029 confirmatory biopsies (CxPBx) of men treated with AS, of which 726 men had both diagnostic (initial) and CxPBx information available. We did a descriptive analysis and evaluated sensitivity, specificity, and predictive values of DRE for the detection of clinically significant PCa (csPCa). Multivariable regression analysis was done to identify predictors of csPCa. The primary outcome was to evaluate DRE as a predictor of the presence of csPCa at CxPBx. Results: Among the 2029 patients with a CxPBx, 75% had PCa, and of these, 30.3% had upgrading to International Society of Urologic Pathologists (ISUP) grade ≥2. Thirteen percent of men had a suspicious DRE (done by their treating physician). Sensitivity, specificity, negative and positive predictive values of DRE to detect csPCa were best with a prostate-specific antigen (PSA) |
| وصف الملف: | application/pdf |
| تدمد: | 1920-1214 1911-6470 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff3bb160321b18f58fa8fd8fcb64010Test https://doi.org/10.5489/cuaj.6341Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3ff3bb160321b18f58fa8fd8fcb64010 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19201214 19116470 |
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