Kynurenine/Tryptophan Ratio as a Potential Blood-Based Biomarker in Non-Small Cell Lung Cancer
| العنوان: | Kynurenine/Tryptophan Ratio as a Potential Blood-Based Biomarker in Non-Small Cell Lung Cancer |
|---|---|
| المؤلفون: | Sara Baglivo, Francesca Romana Tofanetti, Jacopo Vannucci, Francesco Puma, Martina Mandarano, Angelo Sidoni, Rita Chiari, Elena Orecchini, Vienna Ludovini, Guido Bellezza, Elisabetta Loreti, Maria Laura Belladonna |
| المصدر: | International Journal of Molecular Sciences Volume 22 Issue 9 International Journal of Molecular Sciences, Vol 22, Iss 4403, p 4403 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Lung Neoplasms, serum biomarkers, non-small cell lung cancer (NSCLC), indoleamine-2, B7-H1 Antigen, chemistry.chemical_compound, Carcinoma, Non-Small-Cell Lung, kynurenine/tryptophan (Kyn/Trp) ratio, Biology (General), Kynurenine, Spectroscopy, Aged, 80 and over, Tryptophan, General Medicine, Middle Aged, Prognosis, nonsmall cell lung cancer (NSCLC), Computer Science Applications, Survival Rate, Chemistry, medicine.anatomical_structure, indoleamine-2,3-dioxygenase 1 (IDO1), Carcinoma, Squamous Cell, Adenocarcinoma, Female, Adult, QH301-705.5, T cell, Adenocarcinoma of Lung, Article, Catalysis, Inorganic Chemistry, Lymphocytes, Tumor-Infiltrating, Immune system, 3-dioxygenase 1 (IDO1), Biomarkers, Tumor, medicine, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, immunohistochemical biomarkers, Physical and Theoretical Chemistry, Lung cancer, QD1-999, Molecular Biology, Aged, business.industry, Organic Chemistry, Cancer, medicine.disease, chemistry, Cancer research, Neoplasm Recurrence, Local, business, Follow-Up Studies |
| الوصف: | The enzyme indoleamine 2,3-dioxygenase 1 (IDO1) degrade tryptophan (Trp) into kynurenine (Kyn) at the initial step of an enzymatic pathway affecting T cell proliferation. IDO1 is highly expressed in various cancer types and associated with poor prognosis. Nevertheless, the serum Kyn/Trp concentration ratio has been suggested as a marker of cancer-associated immune suppression. We measured Kyn and Trp in blood samples of a wide cohort of non-small-cell lung cancer (NSCLC) patients, before they underwent surgery, and analyzed possible correlations of the Kyn/Trp ratio with either IDO1 expression or clinical–pathological parameters. Low Kyn/Trp significantly correlated with low IDO1 expression and never-smoker patients while high Kyn/Trp was significantly associated with older (≥68 years) patients, advanced tumor stage, and squamous cell carcinoma (Sqcc), rather than the adenocarcinoma (Adc) histotype. Moreover, high Kyn/Trp was associated, among the Adc group, with higher tumor stages (II and III), and, among the Sqcc group, with a high density of tumor-infiltrating lymphocytes. A trend correlating the high Kyn/Trp ratio with the probability of recurrences from NSCLC was also found. In conclusion, high serum Kyn/Trp ratio, associated with clinical and histopathological parameters, may serve as a serum biomarker to optimize risk stratification and therapy of NSCLC patients. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7219228cb0e6b43e93b43a38f60c5f6bTest http://hdl.handle.net/11391/1492548Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7219228cb0e6b43e93b43a38f60c5f6b |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |