المؤلفون: Ron Dubreuil, Nava Segev

المصدر: Cellular logistics. 1(4)

مصطلحات موضوعية: biology, Phagocyte, Virulence, RAB1, Pathogenic bacteria, Cell Biology, biology.organism_classification, medicine.disease_cause, Biochemistry, DNA-binding protein, Microbiology, Cell biology, medicine.anatomical_structure, Editorial, medicine, Molecular Medicine, Secretion, Bacteria, Intracellular

الوصف: Intracellular pathogenic bacteria contrive processes in their host cell to create a niche for their own reproduction. One way that has emerged by which bacteria do that is delivery of secreted virulence factors, SVFs, to the cytoplasm of the host cells using the bacterial type IV secretion system, T4SS. These SVFs modulate the activity of their target host proteins, which in turn control key cellular processes. A major mechanism for the evolution of SVFs that modulate targets that do not exist in the bacterial kingdom is horizontal gene transfer. Recently, a number of bacterial SVFs were shown to act on two types of targets in host cells. First, a group of several SVFs modulate the activity and localization of one protein: Rab1 GTPase, a key regulator of intracellular trafficking. Second, ankyrin repeats-containing SVFs, referred to by microbiologists as Anks, interact with various binding proteins, which in turn regulate a myriad of cellular processes, including apoptosis. Modulation of trafficking and apoptosis are two examples of how invading bacteria takeover their host phagocyte, which instead of destroying the bacteria becomes a factory for its reproduction.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ef81b8d73c3b5dda8ff6bd0c69ea7eTest
https://pubmed.ncbi.nlm.nih.gov/22279609Test

المؤلفون: Simon Alford, Nava Segev

مصطلحات موضوعية: medicine.anatomical_structure, Editorial, nervous system, Chemistry, Chemical synapse, medicine, Molecular Medicine, Cell Biology, Neuron, Active zone, Biochemistry, Neuroscience

الوصف: A chemical synapse is a junction between a pre-synaptic neuron and a post-synaptic cell, neuron or non-neuron, through which signals are transmitted by neurotransmitters.The active zone is the site...

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9272404b321aa3f12826c1329f98915Test
https://europepmc.org/articles/PMC3173654Test/