Management of otitis externa with an led-illuminated gel: a randomized controlled clinical trial in dogs
| العنوان: | Management of otitis externa with an led-illuminated gel: a randomized controlled clinical trial in dogs |
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| المؤلفون: | Matteo Cerquetella, Andrea Spaterna, Francesca Beribe, Cecilia Vullo, Andrea Marchegiani, Adolfo Maria Tambella, Annarita Attili, Alessandro Fruganti, Margherita Galosi, Angela Palumbo Piccionello |
| المصدر: | BMC Veterinary Research BMC Veterinary Research, Vol 16, Iss 1, Pp 1-14 (2020) |
| بيانات النشر: | BioMed Central, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Local pain, Male, Light, 0403 veterinary science, 030207 dermatology & venereal diseases, 0302 clinical medicine, Dog, Otitis, Dog Diseases, Enrofloxacin, lcsh:Veterinary medicine, 04 agricultural and veterinary sciences, General Medicine, Photobiomodulation, Silver Sulfadiazine, Anti-Bacterial Agents, medicine.anatomical_structure, Otitis, Otitis externa, Photobiomodulation, Fluorescence biomodulation, Biophotonics, Phototherapy, Light, Topical administration, Dog, Inflammation, Female, medicine.symptom, medicine.drug, Research Article, medicine.medical_specialty, 040301 veterinary sciences, Pain, Silver sulfadiazine, Fluorescence, Fluorescence biomodulation, 03 medical and health sciences, Dogs, Fluorescent light, Internal medicine, medicine, Animals, Ear canal, Topical administration, Inflammation, General Veterinary, business.industry, Phototherapy, Otitis Externa, Topical medication, Clinical trial, Anti-Infective Agents, Local, lcsh:SF600-1100, Biophotonics, business, Gels |
| الوصف: | Background Canine otitis externa is a painful condition which can be challenging to treat due to difficulties in the administration of otic medication. This can be due to lack of owner compliance in the application of ear drops or due to the resentment that some dogs demonstrate when attempts are made to administer topical medication into a sensitive ear canal. The aim of the study was to assess the efficacy of a topical LED-illuminated gel (LIG) in canine otitis externa in comparison to standard of care therapy. Dogs with spontaneous otitis externa were randomly allocated in three groups: groups QW received LIG once weekly; BW received LIG twice weekly; group C received enrofloxacin and silver sulfadiazine twice daily. LIG consists of a topical application of a gel containing chromophores that, when illuminated by a LED lamp, re-emit fluorescent light which can stimulate physiological responses, promoting healing and controlling bacteria. The evaluation protocol (T0 to T5) considered clinical assessment (OTIS-3-index-scoring-system; pruritus-severity-scale; pain-severity-score; aural temperature), cytological scoring system, quali-quantitative bacteriologic assessment. Results All groups (QW, n = 21; BW, n = 23; C, n = 20) showed improvement during the study (QW: P P P − 4 for pruritus, total OTIS-3 and temperature assessments; BW: P − 4 for all clinical, cytological and bacteriologic assessments; C: P P − 4 for bacteriologic assessment). The highest clinical score reduction occurred in Group BW (P 3; P 4 and P − 4 in T5). BW reached the clinically relevant effect level at T3 (− 3.26 ± 1.21 levels), QW reached it at T4 (− 3.24 ± 0.99), C did not reach it. No differences between groups were seen in the reduction of CFU/mL (T0-T5). Conclusions All treatment groups showed a positive clinical effect. LIG administered twice-a-week was the most favourable protocol of the study. LIG may be considered beneficial in the management of canine otitis externa; it seems to be effective in controlling the clinical condition, including the signs of inflammation and local pain, the bacterial growth, and it may help increasing treatment compliance. |
| اللغة: | English |
| تدمد: | 1746-6148 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739b13f485a709a2efb0fd808b152d7eTest http://europepmc.org/articles/PMC7083025Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....739b13f485a709a2efb0fd808b152d7e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17466148 |
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