المؤلفون: Nava Segev, Zhanna Lipatova

المصدر: Cellular logistics. 4(3)

مصطلحات موضوعية: Endosome, Endocytic cycle, RAB1, Cell Biology, GTPase, Golgi apparatus, Biology, Biochemistry, Cell biology, Article Addendum, symbols.namesake, medicine.anatomical_structure, Lysosome, symbols, medicine, Molecular Medicine, Rab, Secretory pathway

الوصف: A prevailing question in the Ypt/Rab field is whether these conserved GTPases are specific to cellular compartments. The established role for Ypt1 and its human homolog Rab1 is in endoplasmic reticulum (ER)-to-Golgi transport. More recently these regulators were implicated also in autophagy. Two different TRAPP complexes, I and III, were identified as the guanine-nucleotide-exchange factors (GEFs) of Ypt1 in ER-to-Golgi transport and autophagy, respectively. Confusingly, Ypt1 and TRAPP III were also suggested to regulate endosome-to-Golgi transport, implying that they function at multiple cellular compartments, and bringing into question the nature of Ypt/Rab specificity. Recently, we showed that the role of TRAPP III and Ypt1 in autophagy occurs at the ER and that they do not regulate endosome-to-Golgi transport. Here, we discuss the significance of this conclusion to the idea that Ypt/Rabs are specific to cellular compartments. We postulate that Ypt1 regulates 2 alternative routes emanating from the ER toward the Golgi and the lysosome/vacuole. We further propose that the secretory and endocytic/lysosomal pathways intersect in 2 junctures, and 2 Ypts, Ypt1 and Ypt31, coordinate transport in the 2 intersections: Ypt1 links ER-to-Golgi and ER-to-autophagy transport, whereas Ypt31 links Golgi-to-plasma membrane (PM) transport with PM-to-Golgi recycling through endosomes.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565f994a053d62693620c50428cf78a8Test
https://pubmed.ncbi.nlm.nih.gov/25610722Test

المؤلفون: Ron Dubreuil, Nava Segev

المصدر: Cellular logistics. 1(4)

مصطلحات موضوعية: biology, Phagocyte, Virulence, RAB1, Pathogenic bacteria, Cell Biology, biology.organism_classification, medicine.disease_cause, Biochemistry, DNA-binding protein, Microbiology, Cell biology, medicine.anatomical_structure, Editorial, medicine, Molecular Medicine, Secretion, Bacteria, Intracellular

الوصف: Intracellular pathogenic bacteria contrive processes in their host cell to create a niche for their own reproduction. One way that has emerged by which bacteria do that is delivery of secreted virulence factors, SVFs, to the cytoplasm of the host cells using the bacterial type IV secretion system, T4SS. These SVFs modulate the activity of their target host proteins, which in turn control key cellular processes. A major mechanism for the evolution of SVFs that modulate targets that do not exist in the bacterial kingdom is horizontal gene transfer. Recently, a number of bacterial SVFs were shown to act on two types of targets in host cells. First, a group of several SVFs modulate the activity and localization of one protein: Rab1 GTPase, a key regulator of intracellular trafficking. Second, ankyrin repeats-containing SVFs, referred to by microbiologists as Anks, interact with various binding proteins, which in turn regulate a myriad of cellular processes, including apoptosis. Modulation of trafficking and apoptosis are two examples of how invading bacteria takeover their host phagocyte, which instead of destroying the bacteria becomes a factory for its reproduction.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ef81b8d73c3b5dda8ff6bd0c69ea7eTest
https://pubmed.ncbi.nlm.nih.gov/22279609Test

المؤلفون: Simon Alford, Nava Segev

مصطلحات موضوعية: medicine.anatomical_structure, Editorial, nervous system, Chemistry, Chemical synapse, medicine, Molecular Medicine, Cell Biology, Neuron, Active zone, Biochemistry, Neuroscience

الوصف: A chemical synapse is a junction between a pre-synaptic neuron and a post-synaptic cell, neuron or non-neuron, through which signals are transmitted by neurotransmitters.The active zone is the site...

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9272404b321aa3f12826c1329f98915Test
https://europepmc.org/articles/PMC3173654Test/