دورية أكاديمية
IL-20 Cytokines Are Involved in Epithelial Lesions Associated with Virus-Induced COPD Exacerbation in Mice.
| العنوان: | IL-20 Cytokines Are Involved in Epithelial Lesions Associated with Virus-Induced COPD Exacerbation in Mice. |
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| المؤلفون: | Le Roux, Mélina, Ollivier, Anaïs, Kervoaze, Gwenola, Beke, Timothé, Gillet, Laurent, Pichavant, Muriel, Gosset, Philippe |
| المصدر: | Biomedicines, 9 (12), 1838 (2021-12-05) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | COPD, IL-20 cytokines, cigarette, lung, viral infection, Medicine (miscellaneous), Biochemistry, Genetics and Molecular Biology (all), General Biochemistry, Genetics and Molecular Biology, Life sciences, Microbiology, Sciences du vivant, Microbiologie |
| الوصف: | (1) Background: viral infections are a frequent cause of chronic obstructive pulmonary disease (COPD) exacerbations, which are responsible for disease progression and mortality. Previous reports showed that IL-20 cytokines facilitate bacterial lung infection, but their production and their role in COPD and viral infection has not yet been investigated. (2) Methods: C57BL/6 WT and IL-20 Rb KO mice were chronically exposed to air or cigarette smoke (CS) to mimic COPD. Cytokine production, antiviral response, inflammation and tissue damages were analyzed after PVM infection. (3) Results: CS exposure was associated with an increase in viral burden and antiviral response. PVM infection in CS mice enhanced IFN-γ, inflammation and tissue damage compared to Air mice. PVM infection and CS exposure induced, in an additive manner, IL-20 cytokines expression and the deletion of IL-20 Rb subunit decreased the expression of interferon-stimulated genes and the production of IFN-λ2/3, without an impact on PVM replication. Epithelial cell damages and inflammation were also reduced in IL-20 Rb-/- mice, and this was associated with reduced lung permeability and the maintenance of intercellular junctions. (4) Conclusions: PVM infection and CS exposure additively upregulates the IL-20 pathway, leading to the promotion of epithelial damages. Our data in our model of viral exacerbation of COPD identify IL-20 cytokine as a potential therapeutic target. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article peer reviewed |
| اللغة: | English |
| العلاقة: | https://www.mdpi.com/2227-9059/9/12/1838/pdfTest; urn:issn:2227-9059 |
| DOI: | 10.3390/biomedicines9121838 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/292706Test |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2Test info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.292706 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.3390/biomedicines9121838 |
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