دورية أكاديمية
Identification of growth hormone receptor in plexiform neurofibromas of patients with neurofibromatosis type 1
| العنوان: | Identification of growth hormone receptor in plexiform neurofibromas of patients with neurofibromatosis type 1 |
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| المؤلفون: | Karin Soares Gonçalves Cunha, Eliane Porto Barboza, Eliene Carvalho da Fonseca |
| المصدر: | Clinics, Vol 63, Iss 1, Pp 39-42 (2008) |
| بيانات النشر: | Elsevier España, 2008. |
| سنة النشر: | 2008 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | Von Recklinghausen´s disease, Immunohistochemistry, Puberty, Medicine (General), R5-920 |
| الوصف: | OBJECTIVE: The aim of this study was to investigate the presence of growth hormone receptor in plexiform neurofibromas of neurofibromatosis type 1 patients. INTRODUCTION: The development of multiple neurofibromas is one of the major features of neurofibromatosis type 1. Since neurofibromas commonly grow during periods of hormonal change, especially during puberty and pregnancy, it has been suggested that hormones may influence neurofibromatosis type 1 neurofibromas. A recent study showed that the majority of localized neurofibromas from neurofibromatosis type 1 patients have growth hormone receptor. METHODS: Growth hormone receptor expression was investigated in 5 plexiform neurofibromas using immunohistochemistry. RESULTS: Four of the 5 plexiform neurofibromas were immunopositive for growth hormone receptor. CONCLUSION: This study suggests that growth hormone may influence the development of plexiform neurofibromas in patients with neurofibromatosis type 1. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1807-5932 1980-5322 |
| العلاقة: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322008000100008Test; https://doaj.org/toc/1807-5932Test; https://doaj.org/toc/1980-5322Test |
| DOI: | 10.1590/S1807-59322008000100008 |
| الوصول الحر: | https://doaj.org/article/741f1fd3f81b4f3e8ff7ee350376a0b4Test |
| رقم الانضمام: | edsdoj.741f1fd3f81b4f3e8ff7ee350376a0b4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18075932 19805322 |
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| DOI: | 10.1590/S1807-59322008000100008 |