دورية أكاديمية
Basophil activation test in the diagnosis of allergic reactions to local anesthetics
| العنوان: | Basophil activation test in the diagnosis of allergic reactions to local anesthetics |
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| المؤلفون: | O. N. Chibisova, G. I. Lugovskaya, O. V. Khabarova |
| المصدر: | Медицинский вестник Юга России, Vol 13, Iss 1, Pp 124-128 (2022) |
| بيانات النشر: | State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | basophil activation test, hypersensitivity, local anesthetics, flow cytometry, Medicine (General), R5-920 |
| الوصف: | Objective: to evaluate the detection of in vitro hypersensitivity to local anesthesia drugs by fl ow cytometry.Materials and methods: in the test of activation of basophils, the determination of the hypersensitivity reaction to local anesthetics of groups I, II (154 preparations) in 106 patients and T-lymphocytes of type 2 immune response (CD3 + CD294 +) was carried out by fl ow cytometry using the Allergenicity kit test system. In the history of the examined patients, there was a certain food and/ or drug intolerance.Results: Th e levels of sensitization to diff erent groups of local anesthetics were compared in the basophil activation test. Th e highest levels of hypersensitivity were observed to local anesthetics containing vasoconstrictors, stabilizers. In patients with hypersensitivity to drugs for local anesthesia, an increase in the number of T-lymphocytes of type 2 of the immune response was observed.Conclusions: based on the identifi ed hypersensitivity in the basophil activation test to local anesthesia drugs, the safest anesthetics were established. Th e diagnostic signifi cance of determining the level of T-lymphocytes of type 2 of the immune response in drug hypersensitivity is shown. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Russian |
| تدمد: | 2219-8075 2618-7876 |
| العلاقة: | https://www.medicalherald.ru/jour/article/view/1477Test; https://doaj.org/toc/2219-8075Test; https://doaj.org/toc/2618-7876Test |
| DOI: | 10.21886/2219-8075-2022-13-1-124-128 |
| الوصول الحر: | https://doaj.org/article/7157e450fad6434abc5ab383a3f206e7Test |
| رقم الانضمام: | edsdoj.7157e450fad6434abc5ab383a3f206e7 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 22198075 26187876 |
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| DOI: | 10.21886/2219-8075-2022-13-1-124-128 |