دورية أكاديمية
Efficacy of Tocilizumab in Patients with COVID-19
العنوان: | Efficacy of Tocilizumab in Patients with COVID-19 |
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المؤلفون: | Ahmad Alikhani, Zahra Nekoukar, Minoo Moghimi, Maysam Rezapour, Seyyed Javad Boskabadi, Amir Mohammad Shabani, Hamideh Abbaspour Kasgari |
المصدر: | Journal of Mazandaran University of Medical Sciences, Vol 32, Iss 215, Pp 163-168 (2022) |
بيانات النشر: | Mazandaran University of Medical Sciences, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Medicine LCC:Medicine (General) |
مصطلحات موضوعية: | tocilizumab, il6, covid-19, cytokine storm, Medicine, Medicine (General), R5-920 |
الوصف: | Background and purpose: Tocilizumab (TCZ), a monoclonal antibody against interleukin-6 (IL-6) receptor, is emerged as an alternative treatment for COVID-19 patients with a risk of cytokine storms. This study aimed at investigating the efficacy of TCZ in patients with COVID-19. Materials and methods: In a retrospective observational study, we examined the demographic and clinical characteristics of patients with COVID-19 and also the outcomes of TCZ therapy (Actemra® and Temziva®) in Qaemshahr Razi Hospital. Results: Out of 56 cases, 32 (57.1%) were women and the median age of the patients was 57.5 years. Among the patients, 19 (33.9%) were admitted to ICU where seven (12.7%) were intubated and eight (14.3%) patients deceased. Before TCZ therapy, mean oxygen saturation level was 90.1% which elevated to 93.8% after receiving TCZ (P=0.001). In this study, Temziva® was associated with lower mortality rate compared with Actemra® (P=0.004). Conclusion: TCZ therapy in patients with COVID-19 could improve oxygen saturation level and Temziva® results in lower mortality rate. However, further studies with larger sample size are required to confirm these results. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English Persian |
تدمد: | 1735-9260 1735-9279 |
العلاقة: | http://jmums.mazums.ac.ir/article-1-18510-en.htmlTest; https://doaj.org/toc/1735-9260Test; https://doaj.org/toc/1735-9279Test |
الوصول الحر: | https://doaj.org/article/2375a79d313649439bacab1ec3c2d7a2Test |
رقم الانضمام: | edsdoj.2375a79d313649439bacab1ec3c2d7a2 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 17359260 17359279 |
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