المؤلفون: Faleh Alqahtani, Abdullah H. Alruwaili, Mohammed S. Alasmari, Sultan A. Almazroa, Khaled S. Alsuhaibani, Muhammad F. Rasool, Abdulkarim F. Alruwaili, Sary Alsanea

المصدر: Pharmaceuticals, Vol 16, Iss 12, p 1693 (2023)

مصطلحات موضوعية: ondansetron, physiologically based pharmacokinetics, liver cirrhosis, nausea, vomiting, simulation, Medicine, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1424-8247/16/12/1693Test; https://doaj.org/toc/1424-8247Test

الوصول الحر: https://doaj.org/article/95bc4bde74424fcdbe695473462828c7Test

المؤلفون: Denise Türk (11705909), Laura Maria Fuhr (11705912), Fatima Zahra Marok (11705915), Simeon Rüdesheim (11705918), Anna Kühn (11705921), Dominik Selzer (1454482), Matthias Schwab (181355), Thorsten Lehr (4872460)

مصطلحات موضوعية: Medicine, Genetics, Pharmacology, Cancer, Computational Biology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Information Systems not elsewhere classified, Dose adaptation, drug–drug–gene interaction, drug–gene interaction, mathematical modeling, pharmacodynamics, pharmacogenetics, pharmacokinetics, physiologically based pharmacokinetics, population pharmacokinetics

العلاقة: https://figshare.com/articles/journal_contribution/Novel_models_for_the_prediction_of_drug_gene_interactions/17013818Test

الإتاحة: https://doi.org/10.6084/m9.figshare.17013818.v1Test

المؤلفون: Warit Ruanglertboon, Michael J. Sorich, Ashley M. Hopkins, Andrew Rowland

المصدر: Pharmaceuticals, Vol 14, Iss 389, p 389 (2021)

مصطلحات موضوعية: concentration-guided dosing, model informed dosing, physiologically based pharmacokinetics, sorafenib, Medicine, Pharmacy and materia medica, RS1-441

العلاقة: https://www.mdpi.com/1424-8247/14/5/389Test; https://doaj.org/toc/1424-8247Test; https://doaj.org/article/1d7acfe08bea40a998b56d5591cd2db2Test

الإتاحة: https://doi.org/10.3390/ph14050389Test
https://doaj.org/article/1d7acfe08bea40a998b56d5591cd2db2Test

المؤلفون: Thorsten Lehr, Hannah Britz, Clinton F. Stewart, Daniel Moj, Walter E. Haefeli, Gerlinde Egerer, Jürgen Burhenne

مصطلحات موضوعية: Drug, Adult, Male, Cancer Research, Physiologically based pharmacokinetic modelling, media_common.quotation_subject, Pharmacology, Toxicology, Hydroxamic Acids, 030226 pharmacology & pharmacy, Pediatrics, Article, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Pharmacokinetics, In vivo, medicine, Humans, Pharmacology (medical), Dosing, Histone deacetylase, Vorinostat, media_common, Aged, Aged, 80 and over, Dose-Response Relationship, Drug, business.industry, Middle Aged, Thrombocytopenia, Histone Deacetylase Inhibitors, Oncology, Pharmacodynamics, 030220 oncology & carcinogenesis, Female, Physiologically based pharmacokinetics, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b42701510c1983fe755fd57a7800a87Test

المؤلفون: Celine Bolwerk, Cecile Magis-Escurra, Wouter Hoefsloot, Laurens F. M. Verscheijden, Arjan van Laarhoven, David M. Burger, Jakko van Ingen, Jan B. Koenderink, Frans G. M. Russel, Reinout van Crevel, Rob E. Aarnoutse, Martin J. Boeree, Rovina Ruslami, Petra H.H. van den Broek, Carlijn H. C. Litjens, Lindsey H.M. te Brake, Elin M. Svensson, Jeroen J. M. W. van den Heuvel, Saskia Kuipers, Rick Greupink

المصدر: Journal of Clinical Pharmacology and Journal of New Drugs, 62, 3, pp. 385-396
Journal of Clinical Pharmacology and Journal of New Drugs, 62, 385-396

مصطلحات موضوعية: Adult, Drug, drug-drug interactions, Tuberculosis, media_common.quotation_subject, Moxifloxacin, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Pharmacokinetic modeling, Antitubercular Agents, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Pharmacology and Toxicology, Pharmacology, Multiple dose, Models, Biological, physiologically based pharmacokinetics, Pharmaceutical Sciences, Pharmacokinetics, In vivo, medicine, Humans, Pharmacology (medical), ATP Binding Cassette Transporter, Subfamily B, Member 1, Glucuronosyltransferase, Child, media_common, business.industry, modeling, Farmakologi och toxikologi, Farmaceutiska vetenskaper, bacterial infections and mycoses, medicine.disease, Multidrug Resistance-Associated Protein 2, HEK293 Cells, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], tuberculosis, Area Under Curve, Drug Therapy, Combination, Rifampin, moxifloxacin, business, Rifampicin, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e627cee41f24ef6bdaceab6a4f0d8bTest
https://doi.org/10.1002/jcph.1972Test

المؤلفون: Yi Lu, Zhongjian Chen, Wei Wu, Pijush Kumar Paul, Quangang Zhu, Jianping Qi

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2416-2448 (2021)

مصطلحات موضوعية: CPP, cell penetrating peptide, RGD, Arg-Gly-Asp, FA - Folic acid, DDVAP, desmopressin acetate, GRAS, generally recognized as safe, PLA, poly(latic acid), EPR, electron paramagnetic resonance, pI, isoelectric point, PLGA, poly(lactic-co-glycolic acid), MSNs, mesoporous silica nanoparticles, Review, FcRn, Fc receptor, GIPET, gastrointestinal permeation enhancement technology, SGC, sodium glycocholate, Bioinformatics, FA, folic acid, EDTA, ethylene diamine tetraacetic acid, 0302 clinical medicine, Medicine, MCT-1, monocarborxylate transporter 1, General Pharmacology, Toxicology and Pharmaceutics, health care economics and organizations, PBPK, physiologically based pharmacokinetics, STC, sodium taurocholate, 0303 health sciences, IBD, inflammatory bowel disease, pHPMA, N-(2-hydroxypropyl)methacrylamide, PVA, poly vinyl alcohol, Enzyme inhibitor, HPMCP, hydroxypropyl methylcellulose phthalate, CaP, calcium phosphate, GI, gastrointestinal, PGA, poly-γ-glutamic acid, Oral delivery, HBsAg, hepatitis B surface antigen, TMC, N-trimethyl chitosan, Permeation enhancer, LBNs, lipid-based nanoparticles, 030220 oncology & carcinogenesis, SNEDDS, self-nanoemulsifying drug delivery systems, Parenteral route, SDC, sodium deoxycholate, DCs, dendritic cells, SIF, simulated intestinal fluids, NLCs, nanostructured lipid carriers, Stability, VB12, vitamin B12, WGA, wheat germ agglutinin, education, High selectivity, RM1-950, EPD, empirical phase diagrams, Clinical, 03 medical and health sciences, PPs, proteins and peptides, TfR, transferrin receptors, CAGR, compound annual growth, LMWP, low molecular weight protamine, SAR, structure–activity relationship, Tf, transferrin, IBD - Inflammatory bowel disease, sCT, salmon calcitonin, sc, subcutaneous, GLP-1, glucagon-like peptide 1, Tf transferrin, 030304 developmental biology, PCL, polycarprolacton, PCA, principal component analysis, ILs, ionic liquids, business.industry, Proteins, NAC, N-acetyl-l-cysteine, UEA1, ulex europaeus agglutinin 1, SLNs, solid lipid nanoparticles, PAA, polyacrylic acid, SGF, simulated gastric fluids, DTPA, diethylene triamine pentaacetic acid, GALT, gut-associated lymphoid tissue, CD - Crohn's disease, Clinical trial, FDA, U.S. Food and Drug Administration, UC, ulcerative colitis, SNAC, sodium N-[8-(2-hydroxybenzoyl)amino]caprylate, COPD, chronic obstructive pulmonary disease, RTILs, room temperature ionic liquids, TAT, trans-activating transcriptional peptide, UC - Ulcerative colitis, BSA, bovine serum albumin, CD, Crohn's disease, Therapeutics. Pharmacology, ASBT, apical sodium-dependent bile acid transporter, Peptides, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6732d4326595a5ad29955ebaff92173Test
https://doi.org/10.1016/j.apsb.2021.04.001Test

المؤلفون: Xiaomei I. Liu, Dionna J. Green, John N. van den Anker, Natella Y. Rakhmanina, Homa K. Ahmadzia, Jeremiah D. Momper, Kyunghun Park, Gilbert J. Burckart, André Dallmann

المصدر: Frontiers in Pediatrics
Frontiers in Pediatrics, Vol 9 (2021)

مصطلحات موضوعية: Drug, Physiologically based pharmacokinetic modelling, media_common.quotation_subject, Pharmacology, Pediatrics, Umbilical vein, RJ1-570, chemistry.chemical_compound, physiologically based pharmacokinetics (PBPK), Pharmacokinetics, Placenta, Medicine, Distribution (pharmacology), placental drug transfer, media_common, Original Research, Fetus, business.industry, mechanistic modeling, maternal-fetal, medicine.anatomical_structure, chemistry, Dolutegravir, Pediatrics, Perinatology and Child Health, pregnancy, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8983d21c31d41a5acbdda746c80ed7Test
http://europepmc.org/articles/PMC8559552Test

المؤلفون: Paola Mian, Bridget Nolan, John N. van den Anker, Kristel van Calsteren, Karel Allegaert, Nisha Lakhi, André Dallmann

المساهمون: Pharmacy

المصدر: Frontiers in Pediatrics, 9:733520. Frontiers Media S.A.
Frontiers in Pediatrics, Vol 9 (2021)
Frontiers in Pediatrics

مصطلحات موضوعية: Physiologically based pharmacokinetic modelling, In silico, METABOLISM, Pharmacology, PLASMA PARTITION-COEFFICIENTS, Pediatrics, Umbilical vein, RJ1-570, Pharmacokinetics, Placenta, Medicine, EXPOSURE, DRUG, ex vivo cotyledon perfusion, TISSUE DISTRIBUTION, Original Research, acetaminophen, Fetus, Science & Technology, business.industry, maternal-fetal, placental transfer, medicine.anatomical_structure, physiologically-based pharmacokinetics, Pediatrics, Perinatology and Child Health, pregnancy, business, Life Sciences & Biomedicine, Perfusion, PREGNANT-WOMEN, Ex vivo

وصف الملف: application/pdf; Electronic-eCollection

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970ef7458b75051937d20e7f4c6dd4aaTest
https://pure.eur.nl/en/publications/b4f6806e-4a71-41cf-852b-4cbbc5047a27Test

المؤلفون: Su Jin Rhee, Geun Seog Song, Myeongjoong Kim, Heechan Lee, Seunghwan Lee, Seokuee Kim, In Jin Jang, Deok Yong Yoon, Bongtae Kim

المصدر: Pharmaceutics, Vol 13, Iss 1489, p 1489 (2021)
Pharmaceutics
Volume 13
Issue 9

مصطلحات موضوعية: Physiologically based pharmacokinetic modelling, CYP3A4, business.industry, Pharmacokinetic modeling, Drug-drug interaction, Pharmaceutical Science, tegoprazan, PK Parameters, Pharmacology, physiologically based pharmacokinetics, Article, RS1-441, Pharmacy and materia medica, Pharmacokinetics, potassium-competitive acid blocker, Distribution (pharmacology), Medicine, Ketoconazole, drug–drug interaction, business, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7cbabb381935d12f282adc1c66a42a5Test
https://www.mdpi.com/1999-4923/13/9/1489Test

المؤلفون: Paola Coppola, Susan Cole, Essam Kerwash

المصدر: Frontiers in Pediatrics, Vol 9 (2021)
Frontiers in Pediatrics

مصطلحات موضوعية: Physiologically based pharmacokinetic modelling, foetal PBPK, Population, physiologically-based pharmacokinetics modelling, Context (language use), Regulatory Application, breastfeeding PBPK, 030226 pharmacology & pharmacy, Pediatrics, RJ1-570, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, medicine, PBPK qualification, education, Pregnancy, education.field_of_study, business.industry, Perspective (graphical), medicine.disease, Risk analysis (engineering), 030220 oncology & carcinogenesis, Perspective, Pediatrics, Perinatology and Child Health, regulatory submissions, business, Risk assessment, pharmacokinetics, pregnancy PBPK

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a2b9dac0e22541c1cbb51748c650fdTest
https://www.frontiersin.org/articles/10.3389/fped.2021.687978/fullTest