المؤلفون: Felagot A. Abebe (11067156), Megan D. Hopkins (5831783), Suraj N. Vodnala (11067159), Robert J. Sheaff (11067162), Angus A. Lamar (2250037)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Physiology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Vitro Screening Assay, inhibitor 2- deoxyglucose, compound screening technique, screening process, cell viability kit, display selectivity, drug candidates, drug compounds, cytotoxicity screening methods, 30 novel compounds, Selective Anticancer Agents, cell viability assays, Metabolic Inhibitors, pancreatic cancer cell line, cell lines

العلاقة: https://figshare.com/articles/journal_contribution/Development_of_a_Rapid_i_In_Vitro_i_Screening_Assay_Using_Metabolic_Inhibitors_to_Detect_Highly_Selective_Anticancer_Agents/14900388Test

الإتاحة: https://doi.org/10.1021/acsomega.1c02203.s001Test

المؤلفون: Melis Debreli Coskun, Thangirala Sudha, Dhruba J. Bharali, Serap Celikler, Paul J. Davis, Shaker A. Mousa

المساهمون: Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü., Coşkun, Melis Debreli, Çelikler, Serap, CML-2517-2022

المصدر: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 11 (2020)

مصطلحات موضوعية: 0301 basic medicine, peripheral neuropathy, Unclassified drug, Mouse, medicine.medical_treatment, pancreatic cancer, cisplatin, Interleukin 6, Signal transduction, Treatment response, Animal tissue, NF-κB, Interleukin 10, 0302 clinical medicine, Alpha(v)beta(3) antagonists, Pancreatic tumor, Alpha v beta 3 integrin receptor antagonist, Protein blood level, Pharmacology (medical), Cancer inhibition, Interleukin 10 blood level, Pancreas cancer, Original Research, Induced peripheral neurotoxicity, Cancer resistance, Xt 199, Interleukin 1beta, NF-kappa B, Body position, Transcription initiation, Inflammatory cytokines, Neuroprotection, Hindlimb, Cytokine, Antineoplastic agent, 030220 oncology & carcinogenesis, Female, Tumor necrosis factor alpha, Bioluminescence, Thyroid-hormone, Animal cell, Protein determination, Tumor necrosis factor blood level, motor dysfunction, medicine.drug, [[4 [4 [3 [3 [poly 2 (2 hydroxyacetotoxy)]propanamido]aminopropoxy] 3,5 diiodophenoxy] 3,5 diiodophenyl] acetic acid], Combination therapy, Tumor necrosis factor, Drug potentiation, Histopathology, Article, Proinflammatory cytokine, 03 medical and health sciences, Pancreatic cancer, medicine, Cancer model, Animal model, Animal experiment, 3 [3 [3 (4, 5 dihydroimidazol 2 ylamino)propyloxylisoxazol 5 yl]carbonylamino] 2 (phenylsulfonylamino)propionic acid, Receptor blocking agent, Interleukin 1beta blood level, SUIT2-luc cancer cell line, Drug-resistance, Antineoplastic activity, αvβ3 integrin receptor antagonist, Cisplatin, Pharmacology, Multidrag-resistance, Pharmacology & pharmacy, Tumor necrosis, business.industry, lcsh:RM1-950, Pancreatic cancer cell line, Monotherapy, Nonhuman, medicine.disease, Integrin, Thyroid Hormones, Nano-Diamino-Tetrac, Cancer combination chemotherapy, Vitronectin receptor antagonist, Drug efficacy, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, Immunoglobulin enhancer binding protein, Oxidative stress, Cancer cell, Cancer research, Tetraiodothyroacetic aicd, Protein expression, Targeted delivery, Vitronectin receptor, Interleukin 6 blood level, business, Controlled study

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec93b71b364edfe0bd541004eb40a9e8Test

المؤلفون: Mpekris, F., Papageorgis, P., Polydorou, C., Voutouri, C., Kalli, M., Pirentis, A. P., Stylianopoulos, T.

المساهمون: Stylianopoulos, T. [0000-0002-3093-1696]

المصدر: Journal of Controlled Release

مصطلحات موضوعية: Male, Pancreatic cancers, Pathology, Pyridines, medicine.medical_treatment, Diseases, fibroblast, Polyethylene Glycols, sonic hedgehog protein, Mice, Breast cancer, primary tumor, analogs and derivatives, 0302 clinical medicine, Mice, Inbred NOD, Antineoplastic Combined Chemotherapy Protocols, vismodegib, drug delivery system, Medicine, Enzyme activity, Sonic hedgehog, Tumor, pancreatic cancer cell line, gemcitabine, Hedgehog signaling pathway, 3. Good health, Nanomedicine, priority journal, Tumor microenvironment, 030220 oncology & carcinogenesis, Collagen, medicine.medical_specialty, Tumor perfusion, Hyaluronic acid, Sonic hedgehogs, Re-engineering cancer, Vismodegib, Antineoplastic Agents, pyridine derivative, anilide, SCID, doxorubicin, Article, pancreas tumor, animal tissue, 03 medical and health sciences, Pancreatic cancer, cancer combination chemotherapy, Humans, human, mouse, antagonists and inhibitors, Tumors, human cell, animal model, intracellular signaling, Fluid stress, Fibroblasts, medicine.disease, drug efficacy, Pancreatic Neoplasms, cell proliferation, 030104 developmental biology, tumor volume, Nanoparticles, Inbred NOD, Albumin-Bound Paclitaxel, hydraulic conductivity, Medical nanotechnology, 0301 basic medicine, transcription factor Gli1, transcription factor Gli2, Pharmaceutical Science, Mice, SCID, paclitaxel, Drug Delivery Systems, Blood vessels, Tumor Microenvironment, animal, Anilides, macrogol derivative, Extracellular matrices, antineoplastic agent, biology, breast tumor, nanoparticle, Extracellular Matrix, Enzyme inhibition, female, stroma cell, Female, medicine.drug, extracellular matrix, animal experiment, Breast Neoplasms, Cell Line, tissue pressure, male, Cell Line, Tumor, Chemotherapy, Animals, Young modulus, SCID mouse, controlled study, Hedgehog Proteins, drug screening, nonhuman, business.industry, nonobese diabetic mouse, tumor cell line, Cancer, Xenograft Model Antitumor Assays, tumor xenograft, pancreas adenocarcinoma, cancer associated fibroblast, Mechanical force, Doxorubicin, Drug delivery, Cancer research, biology.protein, pathology, Ki 67 antigen, Cell culture, alpha smooth muscle actin, business, metabolism

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064e94bb3e41b1f17f395234f6f126fcTest
https://doi.org/10.1016/j.jconrel.2017.06.022Test

المؤلفون: Btissame El Hassouni, Stefano Coppola, Pei Pei Che, Giulia Mantini, Matthias Löhr, Elisa Giovannetti, Niccola Funel, Mark Buijs, Godefridus J. Peters, Thomas Schmidt, Omidreza Firuzi, Amir Avan, Rainer Heuchel, Ilaria Carnevale, Luciano Saso

المساهمون: VU University medical center, Radiation Oncology, Medical oncology laboratory, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer biology and immunology

المصدر: Firuzi, O, Che, P P, el Hassouni, B, Buijs, M, Coppola, S, Löhr, M, Funel, N, Heuchel, R, Carnevale, I, Schmidt, T, Mantini, G, Avan, A, Saso, L, Peters, G J & Giovannetti, E 2019, ' Role of c-MET inhibitors in overcoming drug resistance in spheroid models of primary human pancreatic cancer and stellate cells ', Cancers, vol. 11, no. 5, 638 . https://doi.org/10.3390/cancers11050638Test
Cancers, 11(5):638. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers
Cancers, 11(5), 638. MDPI
Cancers, Vol 11, Iss 5, p 638 (2019)
Volume 11
Issue 5

مصطلحات موضوعية: green fluorescent protein, 0301 basic medicine, Cancer Research, scatter factor, endocrine system diseases, pancreatic cancer, drug response, Sulforhodamine B, tivantinib, confocal microscopy, 1 pyrrolidinylcarbonyl] 1h pyrrol 2 ylmethylene] 1, Receptor tyrosine kinase, chemistry.chemical_compound, immunocytochemistry, 0302 clinical medicine, 5 dimethyl 4 [2 (1 pyrrolidinylmethyl), clinical article, luciferase assay, biology, Chemistry, 5 (2,6 dichlorobenzylsulfonyl), 3 [3,5 dimethyl 4 [2 (1 pyrrolidinylmethyl), 1 pyrrolidinylcarbonyl] 1h pyrrol 2 ylmethylene] 1,3 dihydro 2h indol 2 one, crizotinib, gemcitabine, scatter factor receptor, stage specific embryo antigen 4, sulforhodamine B, tivantinib, Article, cancer growth, chemosensitivity, coculture, controlled study, drug resistance, enzyme linked immunosorbent assay, human, human cell, pancreatic cancer cell line, pancreatic stellate cell, protein expression, protein phosphorylation, spheroid cell, Cancer-associated fibroblasts, Drug resistance, Pancreatic cancer, Primary cultures, Three-dimensional culture, 3 [3, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, Oncology, 5 (2, 030220 oncology & carcinogenesis, embryonic structures, Hepatocyte growth factor, cancer-associated fibroblasts, medicine.drug, C-Met, 6 dichlorobenzylsulfonyl), lcsh:RC254-282, Article, primary cultures, 03 medical and health sciences, three-dimensional culture, medicine, Tumor microenvironment, Cell growth, 3 dihydro 2h indol 2 one, medicine.disease, digestive system diseases, 030104 developmental biology, Hepatic stellate cell, Cancer research, biology.protein

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251399fa85971da2170f85f2e11abbceTest
https://research.vumc.nl/en/publications/d7fe9129-9bc6-4f81-b1f1-18e41e367ed4Test

المؤلفون: Ahmad Reza Shahverdi, Hossein Mahboudi, Mahban Rahimifard, Maryam Baeeri, Mahdi Shiri, Mohammad Abdollahi, Mona Navaei-Nigjeh, Abbas Kebriaeezadeh

المصدر: International Journal of Nanomedicine

مصطلحات موضوعية: 0301 basic medicine, Programmed cell death, Cell Survival, Inorganic chemistry, Biophysics, Pharmaceutical Science, diazinon, Bioengineering, medicine.disease_cause, Protective Agents, Biomaterials, Lipid peroxidation, 03 medical and health sciences, chemistry.chemical_compound, Selenium, International Journal of Nanomedicine, Cell Line, Tumor, Drug Discovery, medicine, Humans, Insulin, Viability assay, Cytotoxicity, Original Research, Membrane Potential, Mitochondrial, Caspase 3, Organic Chemistry, Acridine orange, apoptosis, toxicity, organophosphorus, General Medicine, Molecular biology, Caspase 9, Mitochondria, Oxidative Stress, 030104 developmental biology, chemistry, Gene Expression Regulation, human pancreatic cancer cell line, Apoptosis, Toxicity, Nanoparticles, Lipid Peroxidation, Magnesium Oxide, Reactive Oxygen Species, Oxidative stress

وصف الملف: text/html

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728449a88eb0665e46e7a05de4e90a8cTest
https://pubmed.ncbi.nlm.nih.gov/27920530Test

المؤلفون: Umut Fahrioglu, Yavuz Dodurga, Levent Elmas, Mücahit Seçme

مصطلحات موضوعية: 0301 basic medicine, protein p16, protein p53, Cell, cyclin D1, wound healing, IC50, cancer cell culture, retinoblastoma protein, nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase, 0302 clinical medicine, caspase 8, migration inhibition, caspase 3, tissue inhibitor of metalloproteinase 1, tissue inhibitor of metalloproteinase 2, FADD, Neoplasm Metastasis, caspase 9, protein bcl xl, pancreatic cancer cell line, apoptosis, General Medicine, Cell cycle, cell invasion, cytotoxicity assay, cell assay, medicine.anatomical_structure, PUMA protein, priority journal, Apoptotic genes, real time polymerase chain reaction, 030220 oncology & carcinogenesis, cell cycle, coumaric acid, protein Bax, protein bcl 2, in vitro study, Coumaric Acids, trypan blue, Caspase 3, caspase 10, antineoplastic activity, Biology, Real-Time Polymerase Chain Reaction, colony formation, protein Noxa, Article, pancreas tumor, gelatinase B, 03 medical and health sciences, Cyclin D1, Cyclin-dependent kinase, Cell Line, Tumor, Genetics, medicine, Fas associated death domain protein, gene expression profiling, Humans, cyclin dependent kinase 6, death receptor 5, controlled study, Viability assay, death receptor 4, protein Bid, human, tumor necrosis factor receptor associated death domain protein, cell viability, cyclin dependent kinase 4, gelatinase A, human cell culture, protein p21, human cell, Cell cycle genes, tumor cell line, Ferulic acid, Pancreatic cancer, phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase, tumor invasion, Molecular biology, Treatment, Pancreatic Neoplasms, 030104 developmental biology, cell viability assay kit, drug effects, biology.protein, Cancer research, gene expression, protein kinase B, pathology, Cyclin-dependent kinase 6

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73dae84464d88c2af7195c2db5f386c5Test
https://doi.org/10.1016/j.gene.2015.10.061Test

المؤلفون: Masanori Sugiyama, Keiji Hanada, Masaki Itoh, Manabu Hirata, Goro Kajiyama, Eiji Kinoshita

المصدر: FEBS Letters. (1):85-87

مصطلحات موضوعية: medicine.medical_treatment, Cell, Proliferation, Biophysics, Venom, Biology, Biochemistry, Phospholipases A, Phospholipase A2, Structural Biology, Pancreatic phospholipase A2 (PLA2), Genetics, medicine, Crotalus adamanteus, Tumor Cells, Cultured, Humans, Binding site, Molecular Biology, Pancreas, Enzyme Precursors, Dose-Response Relationship, Drug, Growth factor, Receptor for PLA2, Pancreatic cancer cell line, Cell Biology, biology.organism_classification, Molecular biology, Binding constant, Pancreatic Neoplasms, Bee Venoms, Kinetics, Phospholipases A2, medicine.anatomical_structure, Digestive enzyme, biology.protein, Cell Division, Protein Binding, Snake Venoms

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1960ea7d622db4152f611ddf05bb347Test