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Novel prognostic determinants of COVID-19-related mortality: A pilot study on severely-ill patients in Russia.

التفاصيل البيبلوغرافية
العنوان: Novel prognostic determinants of COVID-19-related mortality: A pilot study on severely-ill patients in Russia.
المؤلفون: Kseniya Rubina, Anna Shmakova, Aslan Shabanov, Yulii Andreev, Natalia Borovkova, Vladimir Kulabukhov, Anatoliy Evseev, Konstantin Popugaev, Sergey Petrikov, Ekaterina Semina
المصدر: PLoS ONE, Vol 17, Iss 2, p e0264072 (2022)
بيانات النشر: Public Library of Science (PLoS), 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: COVID-19 pandemic has posed a severe healthcare challenge calling for an integrated approach in determining the clues for early non-invasive diagnostics of the potentially severe cases and efficient patient stratification. Here we analyze the clinical, laboratory and CT scan characteristics associated with high risk of COVID-19-related death outcome in the cohort of severely-ill patients in Russia. The data obtained reveal that elevated dead lymphocyte counts, decreased early apoptotic lymphocytes, decreased CD14+/HLA-Dr+ monocytes, increased expression of JNK in PBMCs, elevated IL-17 and decreased PAI-1 serum levels are associated with a high risk of COVID-19-related mortality thus suggesting them to be new prognostic factors. This set of determinants could be used as early predictors of potentially severe course of COVID-19 for trials of prevention or timely treatment.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
العلاقة: https://doaj.org/toc/1932-6203Test
DOI: 10.1371/journal.pone.0264072
الوصول الحر: https://doaj.org/article/9dcc53bf272a47049e7114be791a4c72Test
رقم الانضمام: edsdoj.9dcc53bf272a47049e7114be791a4c72
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0264072