المؤلفون: WANG Kaiwen, DONG He, LYU Lin, LIU Huan, CAI Jinzhen

المصدر: 精准医学杂志, Vol 39, Iss 2, Pp 139-143 (2024)

مصطلحات موضوعية: liver transplantation, transplantation, autologous, fatty liver, liver function tests, arrhythmias, car-diac, lactate dehydrogenases, hydroxybutyrate dehydrogenase, creatine kinase, isoenzymes, troponin, Medicine

الوصف: Objective To explore the effect of moderate fatty liver on cardiac function in orthotopic autologous liver transplantation model rats. Methods Sixty SPF-grade healthy male SD rats were randomly divided into three groups (20 rats in each group). Group A was fed ordinary diet for 6 weeks and underwent laparotomy followed by separation of the blood vessels and ligaments around the liver and abdominal closure; group B was fed ordinary diet for 6 weeks and underwent orthotopic autologous liver transplantation; group C was fed high-fat diet for 6 weeks and underwent orthotopic autologous liver transplantation. The body mass, liver wet mass, liver index, and serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) after 6 weeks of feeding, as well as intraoperative blood pressure, pulse rate, respiratory rate, proportion of arrhythmia occurring in the new liver stage, and serum levels of lactate dehydrogenase (LDH), α-hydroxybutyrate dehydrogenase (α-HBDH), creatine kinase (CK), creatine kinase isoenzyme (CK-MB), and high-sensitivity cardiac troponin (hs-cTn) at 0, 5, 10, and 60 min in the new liver stage were compared. Results The body mass, liver wet mass, liver index, and serum AST and ALT levels, as well as intraoperative systolic blood pressure, diastolic blood pressure, pulse rate, respiratory rate, and proportion of arrhythmia occurring in the new liver stage in group C were significantly higher than those in groups A and B (F=36.40-4 060.54,χ2 =10.91,P0.05). The serum levels of LDH, α-HBDH, CK, CK-MB, and hs-cTn at different time points in the new liver stage were significantly higher in group C than in groups A and B (F=14.11-1 057.08,P

وصف الملف: electronic resource

العلاقة: https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/1716285357236-944367099.pdfTest; https://doaj.org/toc/2096-529XTest

الوصول الحر: https://doaj.org/article/853b864bdd1e43d0ac488b266fc63623Test

المؤلفون: Thomas Silfverberg, Björn Wahlin, Kristina Carlson, Honar Cherif

المصدر: Upsala Journal of Medical Sciences, Vol 127, Pp 1-6 (2022)

مصطلحات موضوعية: hematopoietic stem cell transplantation, covid-19, sars-cov-2 virus, multiple myeloma, lymphoma, immunosuppression therapy, transplantation autologous, Medicine

الوصف: Objective: To describe how coronavirus disease 2019 (COVID-19) affects patients with hematological malignancies treated with autologous hematopoietic stem cell transplantation (ASCT). Methods: This retrospective observational cohort study includes all patients with hematological malignancies treated with ASCT in Sweden from 1 January 2020 to 31 December 2020. Patients who subsequently tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) until 31 March 2021 were analyzed for morbidity, mortality, need for supportive care, and risk factors related to COVID-19. Results: This study identified 442 patients who underwent ASCT in Sweden in 2020, among whom 20 (4.5%) subsequently tested positive for COVID-19. The overall mortality was 15%, and the COVID-19-related mortality was 10% among the patients who contracted COVID-19. Six (35%) patients were hospitalized, of which four (24%) needed supplementary oxygen and two (12%) needed intensive care. The absolute risk of COVID-19-related mortality was 0.45%. Conclusions: ASCT patients have a higher risk of severe outcome of COVID-19 compared to the normal population. However, the risks of death, inpatient care, oxygen therapy, and intensive care seem lower in this study compared to previous studies, possibly due to fewer mildly ill patients in other studies. The risk of contracting SARS-CoV-2 appears to be comparable to that in the general population. This study suggests that the COVID-19 pandemic is not a strong argument for refraining from ASCT in the case of hematological malignancy.

وصف الملف: electronic resource

العلاقة: https://ujms.net/index.php/ujms/article/view/8611/14815Test; https://doaj.org/toc/0300-9734Test; https://doaj.org/toc/2000-1967Test

الوصول الحر: https://doaj.org/article/866f29eb8bdc4147b8ffba3e659601e4Test

المؤلفون: PEDRO NOGUEIRA GIGLIO, NELSON FORESTO LIZIER, DÉBORA LEVY, MARCEL FARACO SOBRADO, RICCARDO GOMES GOBBI, JOSÉ RICARDO PÉCORA, SERGIO PAULO BYDLOWSKI, MARCO KAWAMURA DEMANGE

المصدر: Acta Ortopédica Brasileira, Vol 28, Iss 3, Pp 131-136 (2020)

مصطلحات موضوعية: Cartilage, Celland Tissue-Based Therapy, Transplantation, Autologous, Chondrocytes, Medicine, Orthopedic surgery, RD701-811

الوصف: ABSTRACT Objective: To describe the first series of cases of autologous chondrocyte implantation (ACI) in collagen membrane performed in Brazil. Methods: ACI was performed in 12 knees of 11 patients, aged 32.1 ± 10.9 years, with 5.3 ± 2.6 cm2 full-thickness knee cartilage lesions, with a six-month minimum follow-up. Two surgical procedures were performed: arthroscopic cartilage biopsy for isolation and expansion of chondrocytes, which were seeded onto collagen membrane and implanted in the lesion site; the characterization of cultured cells and implant was performed using immunofluorescence for type II collagen (COL2) for cell viability and electron microscopy of the implant. Clinical safety, KOOS and IKDC scores and magnetic resonance imaging were evaluated. We used repeated-measures ANOVA and post-hoc comparisons at α = 5%. Results: COL2 was identified in the cellular cytoplasm, cell viability was higher than 95% and adequate distribution and cell adhesion were found in the membrane. The median follow-up was 10.9 months (7 to 19). We had two cases of arthrofibrosis, one of graft hypertrophy and one of superficial infection as complications, but none compromising clinical improvement. KOOS and IKDC ranged from 71.2 ± 11.44 and 50.72 ± 14.10, in preoperative period, to 85.0 ± 4.4 and 70.5 ± 8.0, at 6 months (p = 0.007 and 0.005). MRI showed regenerated tissue compatible with hyaline cartilage. Conclusion: ACI in collagen membrane was feasible and safe in a short-term follow-up, presenting regenerated formation visualized by magnetic resonance imaging and improved clinical function. Level of evidence IV, Case series.

وصف الملف: electronic resource

العلاقة: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522020000300131&tlng=enTest; http://www.scielo.br/pdf/aob/v28n3/1809-4406-aob-28-03-131.pdfTest; https://doaj.org/toc/1413-7852Test

الوصول الحر: https://doaj.org/article/133ae0ba4b8c42358d9460dd10bef0dbTest

المؤلفون: Megan A. Kasetty, Andre J. Witkin, Thomas R. Hedges

المصدر: RETINAL Cases & Brief Reports. 16:561-564

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Cellular differentiation, Autosomal Dominant Optic Atrophy, Transplantation, Autologous, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Ophthalmology, medicine, Humans, 0101 mathematics, Optic nerve diseases, business.industry, 010102 general mathematics, Mesenchymal stem cell, Epiretinal Membrane, Mesenchymal Stem Cells, Retinal, General Medicine, Stem-cell therapy, medicine.disease, eye diseases, chemistry, Intravitreal Injections, 030221 ophthalmology & optometry, Stem cell, Epiretinal membrane, business, Tomography, Optical Coherence

الوصف: Purpose The authors describe a case of new bilateral epiretinal membranes and vitreous cells following intravitreal and subTenon's injections of bone marrow-derived stem cells. Methods Case report of a 43-year-old man with OPA-1 autosomal dominant optic atrophy who self-enrolled in a stem cell therapy clinical trial and received simultaneous bilateral intravitreal and subTenon's injections of bone marrow-derived stem cells. Results Within one month of receiving the injections, the patient developed epiretinal membranes and vitreous cells in both eyes, seen with optical coherence tomography. Conclusion Stem cell therapy has been gaining popularity as a potential intervention for progressive retinal and optic nerve diseases; however, the mechanism of action of bone marrow-derived stem cells is still not well understood and may result in unintended cell differentiation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc574068970f68b883ef20cf144a4872Test
https://doi.org/10.1097/icb.0000000000001032Test

المؤلفون: Klemen Stražar, Matej Drobnič, Matic Kolar, Urban Brulc

المصدر: Foot and Ankle Surgery. 28:714-719

مصطلحات موضوعية: Cartilage, Articular, Male, medicine.medical_specialty, Intra-Articular Fractures, Treatment outcome, Psychological intervention, Single Center, Transplantation, Autologous, Talus, Lesion, Quality of life, Humans, Medicine, Orthopedics and Sports Medicine, Prospective Studies, Adverse effect, Retrospective Studies, business.industry, Magnetic Resonance Imaging, Surgery, Treatment Outcome, medicine.anatomical_structure, Quality of Life, Female, Ankle, medicine.symptom, business, Tegner Activity Scale, Ankle Joint

الوصف: Background (1) To evaluate patient-reported outcomes and revision surgeries after various operative interventions for osteochondral lesions of the talus (OLT) in a prospective single center series over 10 years, and (2) to identify predicting factors related to subjective ankle status and quality of life pre- and postoperatively. Methods Ninety-nine patients underwent operative treatment due to primary or recurrent OLT, with an average follow up 3.5 (1.8) years. Treatment outcome was followed clinically (FAOS, EQ-5D, Tegner activity scale) and by pursuing any serious adverse events or graft failures. Results There were 80 responding patients (81%) for the study. The mean lesion size was 2.0 (1.1) cm2. All FAOS values increased from preoperative to final follow-up values (Symptoms 60–68, Pain 58–69, ADL 71–80, Sport 36–54, QoL 30–45). EQ-5D increased from 0.49 to 0.62, while Tegner activity scale change from 3.2 to 3.4. There were 19 (24%) serious adverse events recorded; 13 (16%) of them were graft-related. Graft survival rates were 100% at 1 year, 94% (males)/93% (females) at 2 years, and 77% (males)/47% (females) at 5 years. Female gender, higher BMI, and higher Kellgren-Lawrence ankle OA score were negative predictors for preoperative patient-reported ankle joint status. The foremost improvement after operative intervention was observed in patients with large osteochondral lesions without postoperative adverse events. Conclusion Various operative interventions for OLT significantly improved patients’ ankle status and quality of life. High graft survival rates were demonstrated over first two years, but notable decline was confirmed thereafter, especially in female patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2db7e92a9e0eaf4010e9a99d0047cf2Test
https://doi.org/10.1016/j.fas.2021.08.008Test

المؤلفون: Mahmoud Sakr, Ahmed Mahmoud

المصدر: Clinical and Experimental Otorhinolaryngology, Vol 10, Iss 4, Pp 289-295 (2017)

مصطلحات موضوعية: Thyroid, Transplantation, Autologous, Transplantation, Heterotopic, Thyroidectomy, Review, Medicine, Otorhinolaryngology, RF1-547

الوصف: Total thyroidectomy is increasingly accepted for the management of bilateral benign thyroid disorders. Postoperatively, patients require lifelong levothyroxine replacement therapy to avoid postoperative hypothyroidism, which besides the burden of compliance, has been proven to be associated with several long-term side effects. Heterotopic thyroid autotransplantation was proposed several decades ago to avoid the need for life-long postoperative replacement therapy with maintaining the autoregulatory mechanism of thyroxin production inside the body according to its needs. Available data regarding this topic in literature is relatively poor. Before applying thyroid autotransplantation on humans, several studies have been done on animals, where the autologous transplantations were found to be successful in almost all the cases, proved by follow up postoperative 8-week measurements of thyroid hormones and histopathological examination of the removed autografts. Regarding the clinical application, few trials have been done using cryopreserved in vivo, in vitro or immediately autotransplanted thyroid autografts. Satisfactory results were obtained, however, the number of these studies and the number of patients per each study was very low. Besides the study methodologies were not so consistent.

وصف الملف: electronic resource

العلاقة: http://www.e-ceo.org/upload/pdf/ceo-2016-01578.pdfTest; https://doaj.org/toc/1976-8710Test; https://doaj.org/toc/2005-0720Test

الوصول الحر: https://doaj.org/article/3280e491ec7c4fc3945bf9ff7b06c581Test

المؤلفون: Tasman Armytage, H Rose, Matthew Ku, Hui Peng Lee, Richard Khor, Belinda A. Campbell, Kenneth Lee, Michael Dickinson, Joel Wight, Sze Ting Lee, Maya Latimer, E Verner, Nada Hamad

المصدر: Internal Medicine Journal. 52:1609-1623

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Consensus, Statement (logic), business.industry, Hematopoietic Stem Cell Transplantation, Salvage therapy, Disease, medicine.disease, Transplantation, Autologous, Lymphoma, Clinical trial, Autologous stem-cell transplantation, hemic and lymphatic diseases, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Internal Medicine, medicine, Humans, Lymphoma, Large B-Cell, Diffuse, Rituximab, Early phase, business, Diffuse large B-cell lymphoma

الوصف: Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype, accounting for 30-40% of lymphoma diagnoses. Though aggressive, cure is achievable in approximately 60% of cases with primary chemo-immunotherapy, and in a further substantial minority by salvage therapy and autologous stem cell transplantation. Despite promising activity in early phase clinical trials, no intensified or novel treatment regimen has improved outcomes over R-CHOP21 in randomised studies. However, there remain several areas of controversy including the most appropriate prognostic markers, CNS prophylaxis and the optimal treatment for patients with high-risk disease. This position statement presents an evidence-based synthesis of the literature for application in Australasian practice. This article is protected by copyright. All rights reserved.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c6a9d5d7287ac62f1be67fa936b1ceTest
https://doi.org/10.1111/imj.15533Test

المؤلفون: Chang Yang Yew, SJ Ragg, Rosemary Harrup, Anna M. Johnston, Xuan Ni Tan

المصدر: Internal Medicine Journal. 52:1242-1250

مصطلحات موضوعية: medicine.medical_specialty, Transplantation Conditioning, Psychological intervention, Transplantation, Autologous, Tasmania, Autologous stem-cell transplantation, Intensive care, Antineoplastic Combined Chemotherapy Protocols, Outpatients, Internal Medicine, medicine, Mucositis, Humans, Risk factor, Antibiotic prophylaxis, Melphalan, Multiple myeloma, Febrile Neutropenia, Retrospective Studies, business.industry, Australia, Hematopoietic Stem Cell Transplantation, medicine.disease, Hospitals, Emergency medicine, Multiple Myeloma, business, Febrile neutropenia, Stem Cell Transplantation

الوصف: Background Several international centres have published their experiences with outpatient autologous stem cell transplantation (ASCT) as treatment of haematological malignancies. Aim In this single-centre retrospective review, we aim to examine the outcomes of outpatient autograft and review healthcare resource utilization in the pre-cytopenic period. Methods Patients undergoing ASCT in Royal Hobart Hospital, Tasmania between 2008 and 2018 had their records reviewed and key outcomes data collected based upon whether they received inpatient/outpatient ASCT. An outpatient ASCT was defined as conditioning as an outpatient; patients could then be managed with an elective admission during the cytopenic period or admission only when clinically indicated. Results Of 231 ASCTs performed, 135 (58%) were as outpatients ASCTs: 59 used carmustine-etoposide-cytarabine-melphalan-conditioning for lymphoma (BEAM-ASCT) and 76 used high dose melphalan for myeloma and amyloidosis (MEL-ASCT). Approximately one-third of patients undergoing outpatient ASCT were admitted electively during nadir period; the majority of patients required minimal interventions prior to this time. The most common causes for unplanned hospitalization (which occurred in 71 of the 89 planned outpatient transplants, 80%) were febrile neutropenia (39%) and mucositis (35%). Age was the only risk factor identified to increase risk of requiring unplanned hospitalization. Use of oral antibiotic prophylaxis reduced febrile neutropenia rates amongst melphalan-outpatient-ASCT. Outpatient-ASCTs led to significantly reduced inpatient bed-days and overall cost (approximately AUD $13000- $16,000) compared with inpatient autografts, with no significant differences in engraftment, rates of febrile neutropenia, intensive care admissions or mortality. Conclusion Outpatient autografts may save healthcare resources without compromising patient outcomes. This article is protected by copyright. All rights reserved.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430f74abeb2c07fbeed08597c0b68d2eTest
https://doi.org/10.1111/imj.15334Test

المؤلفون: Christoph Brochhausen, Johannes Oppermann, David Grevenstein, Stavros Oikonomidis, Peer Eysel, Darius Schafigh, Christian K. Spies

المصدر: Technology and Health Care. 30:725-733

مصطلحات موضوعية: Cartilage, Articular, Knee Joint, education, Biomedical Engineering, Biophysics, Health Informatics, Bioengineering, Articular cartilage, Osteoarthritis, Transplantation, Autologous, Biomaterials, Chondrocytes, medicine, Humans, Orthopedic Procedures, Maximum size, Autologous chondrocyte implantation, business.industry, Cartilage, Spheroid, medicine.disease, Treatment Outcome, medicine.anatomical_structure, Radiological weapon, Lateral femoral condyle, Nuclear medicine, business, Information Systems

الوصف: BACKGROUND: Lesions of articular cartilage represent a crucial risk factor for the early development of osteoarthritis. Autologous chondrocyte implantation (ACI) is a well-established procedure in therapy of those lesions in the knee. The aim of the presented study is to detect differences in short-term radiological outcome depending on defect localization (femoral condyle vs. retropatellar) after spheroid-based ACI. OBJECTIVE: This study aimed to demonstrate that radiological outcome after spheroid-based ACI in the knee is independent of defect localization. METHODS: MRI-scans after retropatellar ACI and ACI of the medial/lateral femoral condyle, with a preoperative Outerbridge grade of III or IV were evaluated regarding MOCART 2.0. RESULTS: The mean defect-size was 5.0 ± 1.8 cm2, with a minimum size of 2 cm2 and a maximum size of 9 cm2. Scans were performed 7.7 months (± 3.1 months) postoperatively. The mean MOCART 2.0 score was 78.5 ± 15.6. No statistically significant influence neither of the localization (p= 0.159), the gender (p= 0.124) nor defect size (< 5 cm2 vs. ⩾ 5 cm2; p= 0.201) could be observed. CONCLUSIONS: The presented data demonstrate good to excellent radiological short-term results after spheroid-based ACI. Data indicates, that at least radiological results are independent of gender, defect-size and defect-localization.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddc63bc85a2a9c17eb57ad92b0b7afbTest
https://doi.org/10.3233/thc-213066Test

المؤلفون: Girija Joshi, Shakira J. Grant, Brea Lipe

المصدر: Clin Lymphoma Myeloma Leuk

مصطلحات موضوعية: Cancer Research, Pediatrics, medicine.medical_specialty, Frailty, Vulnerable adult, business.industry, Hematopoietic Stem Cell Transplantation, Hematology, medicine.disease, Transplantation, Autologous, Article, Oncology, Humans, Medicine, Multiple Myeloma, business, Multiple myeloma, Aged

الوصف: Multiple myeloma is primarily a disease of the elderly, and optimal treatments must weigh the risks of toxicity with the benefits of therapy. Frailty scales have been developed to aid treatment-decision making for older adults with MM. This review provides a framework for incorporating frailty scales into clinical care and highlights how patient-aligned priorities for care can influence the management of older or more vulnerable adults with newly diagnosed multiple myeloma newly diagnosed multiple myeloma. We review the currently available systemic therapies for managing older or more vulnerable adults with newly diagnosed multiple myeloma otherwise considered ineligible for autologous stem cell transplantation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce80ef2ef2ab958ff132bad3310ef0cTest
https://doi.org/10.1016/j.clml.2021.11.003Test