Immune checkpoint markers in gastroenteropancreatic neuroendocrine neoplasia
| العنوان: | Immune checkpoint markers in gastroenteropancreatic neuroendocrine neoplasia |
|---|---|
| المؤلفون: | C. Benedikt Westphalen, Annelore Altendorf-Hofmann, Katharina Brüwer, Jens Werner, Thomas Kirchner, Stefan Boeck, Volker Heinemann, Florian Bösch, Gabriele Schubert-Fritschle, Christoph J. Auernhammer, Martin K. Angele, Christine Spitzweg, Thomas Knösel |
| المصدر: | Endocrine-Related Cancer. 26:293-301 |
| بيانات النشر: | Bioscientifica, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Programmed Cell Death 1 Receptor, B7-H1 Antigen, Young Adult, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Endocrinology, Cancer immunotherapy, Stomach Neoplasms, Internal medicine, Intestinal Neoplasms, Biomarkers, Tumor, medicine, Humans, Receptor, Grading (tumors), Aged, Aged, 80 and over, business.industry, Immunotherapy, Middle Aged, Survival Analysis, Immune checkpoint, Small intestine, Gene Expression Regulation, Neoplastic, Pancreatic Neoplasms, Neuroendocrine Tumors, Observational Studies as Topic, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Immunohistochemistry, Female, Neoplasm Grading, business, Pancreas |
| الوصف: | Cancer immunotherapy has evolved major breakthroughs in the last years. The cell-surface receptor programmed death-1 (PD-1) and its ligand, programmed death ligand-1 (PD-L1), have been detected in various cancer types. However, the analysis on gastroenteropancreatic neoplasia (GEP-NENs) is limited. Therefore, the aim of this study was to characterize GEP-NENs with regard to PD-1/PD-L1 pathway and tumor-infiltrating lymphocytes (TILs). On protein level, we examined TILs, PD-1 and PD-L1 expression in tumor tissue of 244 GEP-NENs using immunohistochemistry. Expression levels were correlated with clinicopathological parameters including long-term survival in an observational study. In total, 244 patients could be included. Most of the patients had a NEN of the small intestine (52.5%) or the pancreas (29.5%). All tumors could be graded by their morphology and Ki67 index, with 57.8% G1, 34% G2 and 8.2% G3 tumors. High TILs (19.6%) and high PD-1 (16.1%) expression showed a significant correlation with shorter patient survival (P |
| تدمد: | 1479-6821 1351-0088 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e6d99bda04b43056b2a385562ce650Test https://doi.org/10.1530/erc-18-0494Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c8e6d99bda04b43056b2a385562ce650 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14796821 13510088 |
|---|