Prognostic Significance of Autoantibodies to Laminin in the Sera of Breast Cancer Patients: A Preliminary Report
| العنوان: | Prognostic Significance of Autoantibodies to Laminin in the Sera of Breast Cancer Patients: A Preliminary Report |
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| المؤلفون: | L. Piana, Romain S, Martin Pm, Avrameas S, Barbouche Mr |
| المصدر: | cclm. 32:511-514 |
| بيانات النشر: | Walter de Gruyter GmbH, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Adult, Clinical Biochemistry, Mammary gland, Breast Neoplasms, Breast cancer, Antigen, Laminin, Humans, Medicine, Aged, Autoantibodies, Retrospective Studies, biology, medicine.diagnostic_test, business.industry, Incidence, Biochemistry (medical), Autoantibody, General Medicine, Middle Aged, Prognosis, medicine.disease, Survival Analysis, Immunoglobulin A, medicine.anatomical_structure, Immunoglobulin M, Immunoglobulin G, Immunoassay, Immunology, Cancer cell, biology.protein, Population study, Female, Menopause, business |
| الوصف: | Interactions between cancer cells and laminin play an important role in the metastatic cascade. The aim of this retrospective study was to evaluate the presence and the prognostic significance of autoantibodies to laminin in sera of patients with breast cancer. Our study population consisted of 71 high-risk primary breast cancer patients (median follow-up, 6 years). IgG, IgA and IgM were analysed at the time of surgery and before any treatment was given. Concentrations were measured by enzyme immunoassay with a highly purified antigen. IgG, IgA and IgM anti-laminin median values were, respectively 117%, 130% and 97% of normal absorbance. Higher concentrations of IgM to laminin were found in pre-menopausal patients as compared with post-menopausal patients (p < 0.001). Patients with high concentrations of IgG to laminin had lower disease-free (p = 0.003) and overall survival rates (p = 0.003). In breast cancer, assay of IgG to laminin could thus provide a cheap and easy prognostic index available for all patients. |
| تدمد: | 1437-4331 1434-6621 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7017e1cee59ab92076aabeca35ed1224Test https://doi.org/10.1515/cclm.1994.32.7.511Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7017e1cee59ab92076aabeca35ed1224 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14374331 14346621 |
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