المؤلفون: Daniel Brigger, Pascal Guntern, Theodore S. Jardetzky, Pascal Gasser, Alexander Eggel, Luke F. Pennington

المصدر: J Allergy Clin Immunol

مصطلحات موضوعية: 0301 basic medicine, Allergy, Ovalbumin, Recombinant Fusion Proteins, Immunology, Mice, Transgenic, Yeast display, Immunoglobulin E, Article, Affinity maturation, 03 medical and health sciences, 0302 clinical medicine, Immunology and Allergy, Medicine, Animals, Humans, 610 Medicine & health, Receptor, Anaphylaxis, biology, Molecular Structure, business.industry, Receptors, IgE, Allergens, medicine.disease, Basophils, 030104 developmental biology, 030228 respiratory system, DARPin, Drug Design, biology.protein, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d4146795d788ed6fb76b6035e78caaTest
https://europepmc.org/articles/PMC8502201Test/

المؤلفون: Giovanni Staurenghi, Francisco J. López, Kimmie Kim, Hohman Thomas C, Derek Y Kunimoto, David Callanan, Susan Schneider, Janet K. Cheetham, Sunil S. Patel, Sebastian Wolf, Raj K Maturi

المصدر: Journal of Ocular Pharmacology and Therapeutics
Callanan, David; Kunimoto, Derek; Maturi, Raj K; Patel, Sunil S; Staurenghi, Giovanni; Wolf, Sebastian; Cheetham, Janet K; Hohman, Thomas C; Kim, Kimmie; López, Francisco J; Schneider, Susan (2018). Double-Masked, Randomized, Phase 2 Evaluation of Abicipar Pegol (an Anti-VEGF DARPin Therapeutic) in Neovascular Age-Related Macular Degeneration. Journal of ocular pharmacology and therapeutics, 34(10), pp. 700-709. Mary Ann Liebert 10.1089/jop.2018.0062 <http://dx.doi.org/10.1089/jop.2018.0062Test>

مصطلحات موضوعية: Male, Vascular Endothelial Growth Factor A, 0301 basic medicine, genetic structures, abicipar pegol, Visual Acuity, Angiogenesis Inhibitors, Macular Degeneration, chemistry.chemical_compound, 0302 clinical medicine, Pharmacology (medical), 610 Medicine & health, Anti vegf, vascular endothelial growth factor, humanities, Vascular endothelial growth factor, Treatment Outcome, Choroidal neovascularization, DARPin, anti-VEGF, Intravitreal Injections, Female, medicine.symptom, Tomography, Optical Coherence, medicine.drug, medicine.medical_specialty, Recombinant Fusion Proteins, Abicipar Pegol, choroidal neovascularization, Retina, 03 medical and health sciences, Double-Blind Method, Ranibizumab, Ophthalmology, medicine, Humans, age-related macular degeneration, Aged, Pharmacology, optical coherence tomography, business.industry, Original Articles, Macular degeneration, medicine.disease, eye diseases, 030104 developmental biology, chemistry, 030221 ophthalmology & optometry, sense organs, business, Vascular endothelial growth factor binding

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316feb66c16cd86ddf896bd0bb94c63cTest
https://doi.org/10.1089/jop.2018.0062Test

المؤلفون: Analia Azaro, Jordi Rodon, Constanza Linossi, Richard D. Baird, Ulrike Fiedler, Simon Lord, Keith M. Dawson, Aurelius Omlin, Nicolas Leupin, Andreas Harstrick, Stefanie Fischer, Michael T. Stumpp, Christof Zitt, Mark R. Middleton, Adrian L. Harris

المصدر: Journal of Clinical Oncology

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Vascular Endothelial Growth Factor A, Cancer Research, VEGF receptors, Recombinant Fusion Proteins, Antineoplastic Agents, Cohort Studies, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Neoplasms, Tumor Microenvironment, Medicine, Humans, In patient, Clinical Trials, Molecular Targeted Therapy, Infusions, Intravenous, Aged, biology, Dose-Response Relationship, Drug, business.industry, Drug candidate, Hepatocyte Growth Factor, First in human, ORIGINAL REPORTS, Middle Aged, Phase i study, Vascular endothelial growth factor, 030104 developmental biology, Oncology, DARPin, chemistry, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Hepatocyte growth factor, Female, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16b0da7e7ca61c956dcd61166c92f95Test
https://pubmed.ncbi.nlm.nih.gov/33301375Test

المؤلفون: Charles C. Wykoff, Christina Y. Weng, Seenu M. Hariprasad, Rehan M. Hussain, Raya A. Gandhi

المصدر: Expert opinion on biological therapy. 20(9)

مصطلحات موضوعية: 0301 basic medicine, Vascular Endothelial Growth Factor A, medicine.medical_specialty, genetic structures, VEGF receptors, medicine.medical_treatment, Recombinant Fusion Proteins, Clinical Biochemistry, Abicipar Pegol, Angiogenesis Inhibitors, 03 medical and health sciences, chemistry.chemical_compound, Macular Degeneration, 0302 clinical medicine, Ophthalmology, Age related, Drug Discovery, Choroidal neovascular membrane, medicine, Humans, Pharmacology, Inflammation, Clinical Trials as Topic, biology, business.industry, Growth factor, Macular degeneration, medicine.disease, eye diseases, Vascular endothelial growth factor, 030104 developmental biology, Treatment Outcome, chemistry, DARPin, 030220 oncology & carcinogenesis, biology.protein, sense organs, business, Half-Life, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afc5aba83a743ff1b2d99f32be29a9bTest
https://pubmed.ncbi.nlm.nih.gov/32552072Test

المؤلفون: Pierluigi Navarra, Achille P. Caputi

المصدر: Current opinion in pharmacology. 51

مصطلحات موضوعية: 0301 basic medicine, Ankyrins, Biomedical Research, Settore BIO/14 - FARMACOLOGIA, Recombinant Fusion Proteins, Pharmacology, Antibodies, Monoclonal, Humanized, 030226 pharmacology & pharmacy, Epitope, 03 medical and health sciences, 0302 clinical medicine, Basic research, Drug Discovery, medicine, Drug approval, Ankyrin, Animals, Humans, Drug Approval, chemistry.chemical_classification, Clinical Trials as Topic, biology, 030104 developmental biology, N/A, DARPin, chemistry, biology.protein, Ankyrin repeat, Ranibizumab, Antibody, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd090b82c2b2246193dd5c71bd9d5f0cTest
https://pubmed.ncbi.nlm.nih.gov/32674998Test

المؤلفون: Fereidoun Mahboudi, Fatemeh Davami, Nikta Babaee, Yeganeh Talebkhan Garoosi, Morteza Karimipoor, Hossein Safarpour, Elham Bayat, Farzaneh Barkhordari

المصدر: Molecular biology reports. 47(10)

مصطلحات موضوعية: 0301 basic medicine, Scaffold protein, Small interfering RNA, Recombinant Fusion Proteins, Flow cytometry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cancer stem cell, Genetics, medicine, Biomarkers, Tumor, Humans, RNA, Small Interfering, Molecular Biology, Drug Carriers, Expression vector, medicine.diagnostic_test, Epithelial cell adhesion molecule, General Medicine, Epithelial Cell Adhesion Molecule, Fusion protein, Cell biology, 030104 developmental biology, DARPin, chemistry, 030220 oncology & carcinogenesis, MCF-7 Cells, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026a123ebc6dbc69c4ba08238191393aTest
https://pubmed.ncbi.nlm.nih.gov/32979162Test

المؤلفون: Alexey A. Schulga, Daria Kiseleva, Sergey M. Deyev, Irina V. Balalaeva, E. A. Sokolova, O N Shilova

المصدر: International Journal of Molecular Sciences
Volume 20
Issue 10
International Journal of Molecular Sciences, Vol 20, Iss 10, p 2399 (2019)

مصطلحات موضوعية: 0301 basic medicine, Receptor, ErbB-2, medicine.medical_treatment, Muscle Proteins, immunogenicity, medicine.disease_cause, Targeted therapy, lcsh:Chemistry, Mice, 0302 clinical medicine, Ovarian carcinoma, Pseudomonas exotoxin, Molecular Targeted Therapy, lcsh:QH301-705.5, Spectroscopy, ADP Ribose Transferases, Ovarian Neoplasms, Mice, Inbred BALB C, far-red fluorescent protein, Pseudomonas exotoxin A, Immunogenicity, Immunotoxins, Nuclear Proteins, General Medicine, targeted therapy, Computer Science Applications, DARPin, Liver, 030220 oncology & carcinogenesis, Toxicity, Epitopes, B-Lymphocyte, Heterografts, Female, Cell Survival, Virulence Factors, Recombinant Fusion Proteins, Bacterial Toxins, Exotoxins, Mice, Nude, Antineoplastic Agents, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, Inhibitory Concentration 50, Cell Line, Tumor, HER2, medicine, Biomarkers, Tumor, Animals, Humans, Amino Acid Sequence, Physical and Theoretical Chemistry, Molecular Biology, business.industry, Organic Chemistry, Carcinoma, medicine.disease, Xenograft Model Antitumor Assays, ovarian carcinoma, Disease Models, Animal, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Cancer research, Ovarian cancer, business, Exotoxin, Spleen

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5873f832e09f153de0037e4542245fTest

المؤلفون: Hartmut H. Niemann, Luisa Iamele, Florian Kast, Timo Meyer, Andreas Plückthun, Fabio Andres, Jakob C. Stüber, Ermanno Gherardi

المساهمون: University of Zurich, Plückthun, Andreas

المصدر: Journal of molecular biology. 431(10)

مصطلحات موضوعية: Models, Molecular, Recombinant Fusion Proteins, 610 Medicine & health, Crystallography, X-Ray, Proto-Oncogene Mas, 03 medical and health sciences, 0302 clinical medicine, 1315 Structural Biology, Downregulation and upregulation, Structural Biology, Cell Line, Tumor, Neoplasms, medicine, 10019 Department of Biochemistry, 1312 Molecular Biology, Humans, Kinase activity, Molecular Biology, Protein Kinase Inhibitors, 030304 developmental biology, Cell Proliferation, 0303 health sciences, Chemistry, Cell growth, Kinase, Proto-Oncogene Proteins c-met, Fusion protein, Ankyrin Repeat, DARPin, Cancer cell, Cancer research, 570 Life sciences, biology, Hepatocyte growth factor, 030217 neurology & neurosurgery, medicine.drug

وصف الملف: Andres_et_al._2019.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4bf078fac0e630fdf82379b8b2207cTest
https://pubmed.ncbi.nlm.nih.gov/30930049Test

المؤلفون: Tatiana A. Zdobnova, E. A. Sokolova, Anastasiya V. Ryabova, Olga M Kutova, Oleg A. Stremovskiy, G. M. Proshkina, Sergey M. Deyev, Irina V. Balalaeva, Olga A. Shilova, Alexey A. Schulga

المصدر: Journal of Controlled Release. 233:48-56

مصطلحات موضوعية: 0301 basic medicine, Cell Survival, Receptor, ErbB-2, Virulence Factors, Recombinant Fusion Proteins, medicine.medical_treatment, Bacterial Toxins, Exotoxins, Mice, Nude, Pharmaceutical Science, Antineoplastic Agents, Apoptosis, CHO Cells, Pharmacology, Biology, medicine.disease_cause, Targeted therapy, 03 medical and health sciences, Cricetulus, In vivo, Immunotoxin, Cell Line, Tumor, medicine, Animals, Humans, Cytotoxic T cell, Cytotoxicity, ADP Ribose Transferases, Immunotoxins, Mammary Neoplasms, Experimental, In vitro, Tumor Burden, 030104 developmental biology, DARPin, Female, Exotoxin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4269383d58f8ee329644d912b497aeTest
https://doi.org/10.1016/j.jconrel.2016.05.020Test

المؤلفون: Hélène Chassin, Barbara Geering, Brian M. Lang, Lina Schukur, Martin Fussenegger, David Ausländer

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications, 8 (1)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Recombinant Fusion Proteins, Science, medicine.medical_treatment, General Physics and Astronomy, Immunoglobulin E, medicine.disease_cause, Article, General Biochemistry, Genetics and Molecular Biology, Cell Line, Allergic inflammation, 03 medical and health sciences, Th2 Cells, 0302 clinical medicine, Hypersensitivity, Humans, Medicine, lcsh:Science, Interleukin 4, Interleukin-13, Multidisciplinary, biology, business.industry, General Chemistry, Immunotherapy, Allergens, 3. Good health, 030104 developmental biology, Cytokine, DARPin, Immunology, Allergic response, Interleukin 13, biology.protein, lcsh:Q, Interleukin-4, Genetic Engineering, business, Histamine, Protein Binding, 030215 immunology

وصف الملف: application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0c3de6fcd1343039870d3ee08446fcTest
https://doi.org/10.1038/s41467-017-01211-1Test