نتائج البحث - "Mammalian target of rapamycin (mTOR)"

المصدر: International Journal of Molecular Sciences
Volume 21
Issue 11
International Journal of Molecular Sciences, Vol 21, Iss 4054, p 4054 (2020)

مصطلحات موضوعية: 0301 basic medicine, sodium glucose co-transporter 2 inhibitor, obesity, Mitochondrion, Lamellar granule, lcsh:Chemistry, Kidney Tubules, Proximal, Mice, 0302 clinical medicine, lcsh:QH301-705.5, Spectroscopy, TOR Serine-Threonine Kinases, mammalian target of rapamycin (mTOR), General Medicine, Immunohistochemistry, Computer Science Applications, medicine.medical_specialty, autophagy, Normal diet, Urinary system, Sodium, chemistry.chemical_element, 030209 endocrinology & metabolism, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, Sodium-Glucose Transporter 2, Internal medicine, medicine, Empagliflozin, Animals, Physical and Theoretical Chemistry, Molecular Biology, Sodium-Glucose Transporter 2 Inhibitors, multi lamellar body, business.industry, Organic Chemistry, Autophagy, Autophagosomes, Transporter, Epithelial Cells, Lipid Metabolism, 030104 developmental biology, Endocrinology, lcsh:Biology (General), lcsh:QD1-999, chemistry, business, Lysosomes, Biomarkers

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0c369b4b4180251198e80af404feb5Test
https://pubmed.ncbi.nlm.nih.gov/32517059Test

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Effects of Early Exposure of Isoflurane on Chronic Pain via the Mammalian Target of Rapamycin Signal Pathway

المؤلفون: C. David Mintz, Qun Li, O’Rukevwe Nicole Eregha, Reilley P. Mathena

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 20, p 5102 (2019)
Volume 20
Issue 20

مصطلحات موضوعية: Pharmacology, lcsh:Chemistry, Mice, 0302 clinical medicine, 030202 anesthesiology, Medicine, lcsh:QH301-705.5, Spectroscopy, Cerebral Cortex, Neurons, Isoflurane, TOR Serine-Threonine Kinases, mammalian target of rapamycin (mTOR), Chronic pain, General Medicine, Immunohistochemistry, 3. Good health, Computer Science Applications, medicine.anatomical_structure, Neuropathic pain, Chronic Pain, insular cortex (IC), medicine.drug, Signal Transduction, Spinal Cord Dorsal Horn, Insular cortex, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, Downregulation and upregulation, Animals, Physical and Theoretical Chemistry, Molecular Biology, Anterior cingulate cortex, PI3K/AKT/mTOR pathway, anterior cingulate cortex (ACC), neuropathic pain, business.industry, Ribosomal Protein S6 Kinases, Organic Chemistry, spinal dorsal horn (SDH), medicine.disease, anesthesia neurotoxicity, lcsh:Biology (General), lcsh:QD1-999, Anesthetic, business, 030217 neurology & neurosurgery, Biomarkers

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ce7241e7d4e97cda09820e8fcde791Test
http://europepmc.org/articles/PMC6834214Test

6

MiR-99a Enhances the Radiation Sensitivity of Non-Small Cell Lung Cancer by Targeting mTOR

المؤلفون: Hongyu Ma, Siliang Zhang, Yu Zhang, Shiqi Piao, Yang Li, Qingyong Xu, Yuanyuan Qu, Hang Yin, Jianqun Ma, Xiaoyuan Wang, Lin Chen

المصدر: Cellular Physiology and Biochemistry, Vol 46, Iss 2, Pp 471-481 (2018)

مصطلحات موضوعية: 0301 basic medicine, Lung Neoplasms, Physiology, Cell Survival, Morpholines, Transplantation, Heterologous, Microrna-99a, non-small cell lung cancer (NSCLC), Down-Regulation, Mice, Nude, Non-small cell lung cancer (NSCLC), Biology, Radiation Tolerance, lcsh:Physiology, Radiosensitivity, lcsh:Biochemistry, 03 medical and health sciences, Mice, 0302 clinical medicine, Radiation sensitivity, Radioresistance, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, microRNA, Databases, Genetic, medicine, Animals, Humans, lcsh:QD415-436, 3' Untranslated Regions, Mammalian target of rapamycin (mTOR), PI3K/AKT/mTOR pathway, lcsh:QP1-981, TOR Serine-Threonine Kinases, Cancer, Antagomirs, Cell Cycle Checkpoints, Cell cycle, medicine.disease, MicroRNAs, 030104 developmental biology, Pyrimidines, A549 Cells, Gamma Rays, 030220 oncology & carcinogenesis, Benzamides, Cancer research, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53be94ad7e3019795f1b1f49f0cc75c1Test
https://www.karger.com/Article/FullText/488615Test

7

The preclinical assessment of XL388, a mTOR kinase inhibitor, as a promising anti-renal cell carcinoma agent

المؤلفون: Yiwen Zang, Shanwen Chen, Zuquan Xiong, Zhoujun Shen, Lujia Zou, Qiang Ding, Shenghua Liu, Zujun Fang, Yishuo Wu, Shan Zhong

المصدر: Oncotarget

مصطلحات موضوعية: Male, 0301 basic medicine, Pathology, Drug Evaluation, Preclinical, Apoptosis, mTORC1, urologic and male genital diseases, mTORC2, Mice, 0302 clinical medicine, renal cell carcinoma (RCC), Renal cell carcinoma, Sulfones, TOR Serine-Threonine Kinases, mammalian target of rapamycin (mTOR), Middle Aged, female genital diseases and pregnancy complications, Kidney Neoplasms, Temsirolimus, Oncology, 030220 oncology & carcinogenesis, Female, MEK-ERK, Research Paper, medicine.drug, medicine.medical_specialty, Cell Survival, MAP Kinase Signaling System, Antineoplastic Agents, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, neoplasms, Carcinoma, Renal Cell, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cell Proliferation, Everolimus, business.industry, RPTOR, medicine.disease, Xenograft Model Antitumor Assays, Disease Models, Animal, 030104 developmental biology, Cancer research, business, XL388

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e362e4de42fc56371da8e6456d93e9Test
https://doi.org/10.18632/oncotarget.15620Test

8

Mammalian Target of Rapamycin Inhibitors Permit Regulatory T Cell Reconstitution and Inhibit Experimental Chronic Graft-versus-Host Disease

المؤلفون: Kengo Takeuchi, Yoshinobu Maeda, Katsuji Shinagawa, Takanori Teshima, Hisakazu Nishimori, Eisei Kondo, Takehiro Tanaka, Yoshiko Yamasuji, Ken-ichi Matsuoka, Nobuharu Fujii, Mitsune Tanimoto, Haruko Sugiyama

المصدر: Biology of Blood and Marrow Transplantation. 20(2):183-191

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17a5ffedef5cac1d66d7c526e2fedd9Test
https://ousar.lib.okayama-u.ac.jp/52841Test

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Characterization of the TGF-β1 signaling abnormalities in the Gata1low mouse model of myelofibrosis

المؤلفون: Laura Sancillo, Rosa Alba Rana, Francesca Masiello, Fabrizio Martelli, Giovanni Barosi, Maria Zingariello, Judith D. Goldberg, Xiaochun Li, Fiorella Ciaffoni, Margherita Massa, Anna Rita Migliaccio, Barbara Ghinassi, Emanuela D'Amore

المساهمون: Zingariello, M, Martelli, F, Ciaffoni, F, Masiello, F, Ghinassi, B, D'Amore, E, Massa, M, Barosi, G, Sancillo, L, Li, X, Goldberg, Jd, Rana, Ra, Franco Migliaccio, Anna Rita

المصدر: Blood. 121:3345-3363

مصطلحات موضوعية: Adult, Male, Vascular Endothelial Growth Factor A, Hematopoiesis and Stem Cells, Blotting, Western, Immunology, Spleen, Biology, Real-Time Polymerase Chain Reaction, Primary myelofibrosis (PMF) is characterized by fibrosis, ineffective hematopoiesis in marrow, and hematopoiesis in extramedullary sites and is associated with abnormal megakaryocyte (MK) development and increased transforming growth factor (TGF)-β1 release. To clarify the role of TGF-β1 in the pathogenesis of this disease, the TGF-β1 signaling pathway of marrow and spleen of the Gata1(low) mouse model of myelofibrosis (MF) was profiled and the consequences of inhibition of TGF-β1 signaling on disease manifestations determined. The expression of 20 genes in marrow and 36 genes in spleen of Gata1(low) mice was altered. David-pathway analyses identified alterations of TGF-β1, Hedgehog, and p53 signaling in marrow and spleen and of mammalian target of rapamycin (mTOR) in spleen only and predicted that these alterations would induce consequences consistent with the Gata1(low) phenotype (increased apoptosis and G1 arrest both in marrow and spleen and increased osteoblast differentiation and reduced ubiquitin-mediated proteolysis in marrow only). Inhibition of TGF-β1 signaling normalized the expression of p53-related genes, restoring hematopoiesis and MK development and reducing fibrosis, neovascularization, and osteogenesis in marrow. It also normalized p53/mTOR/Hedgehog-related genes in spleen, reducing extramedullary hematopoiesis. These data identify altered expression signatures of TGF-β1 signaling that may be responsible for MF in Gata1(low) mice and may represent additional targets for therapeutic intervention in PMF, Biochemistry, Transforming Growth Factor beta1, Mice, Bone Marrow, Fibrosis, Biomarkers, Tumor, medicine, Animals, Humans, GATA1 Transcription Factor, RNA, Messenger, RNA, Small Interfering, Myelofibrosis, PI3K/AKT/mTOR pathway, Oligonucleotide Array Sequence Analysis, Ineffective Hematopoiesis, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, TOR Serine-Threonine Kinases, Cell Biology, Hematology, Middle Aged, Flow Cytometry, medicine.disease, Chemokine CXCL12, Extramedullary hematopoiesis, Disease Models, Animal, Haematopoiesis, medicine.anatomical_structure, Primary Myelofibrosis, Case-Control Studies, Cancer research, Cytokines, Bone marrow, Signal Transduction

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c708320f0f269d9717c1cd36e3eb8bcTest
https://doi.org/10.1182/blood-2012-06-439661Test

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Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo

المؤلفون: Wee Kiat Ong, Greg C. Smith, Gordon W. Rewcastle, Peter R. Shepherd, Weiping Han, Jackie D. Kendall

المصدر: Biochemical Journal

مصطلحات موضوعية: Male, Pyridines, medicine.medical_treatment, phosphoinositide 3-kinase catalytic α polypeptide (PIK3CA), LC-MS/MS, liquid chromatography tandem MS, Biochemistry, phosphoinositide 3-kinase (PI3K), BMR, basal metabolic rate, Eating, Mice, PI3KCA, PI3K catalytic α polypeptide, Enzyme Inhibitors, media_common, Phosphoinositide-3 Kinase Inhibitors, ATM, ataxia telangiectasia mutated, Sulfonamides, TOR Serine-Threonine Kinases, mammalian target of rapamycin (mTOR), Imidazoles, Isoenzymes, PIKK, phosphoinositide kinase-related kinase, KI, knockin, Quinolines, GTT, glucose tolerance test, PI3K, phosphoinositide 3-kinase, Research Article, Gene isoform, medicine.medical_specialty, insulin, Class I Phosphatidylinositol 3-Kinases, media_common.quotation_subject, glucose metabolism, mTOR, mammalian target of rapamycin, P110α, Biology, Carbohydrate metabolism, Motor Activity, In vivo, Internal medicine, medicine, Animals, Furans, Molecular Biology, PI3K/AKT/mTOR pathway, ITT, insulin tolerance test, PTT, pyruvate tolerance test, KO, knockout, Insulin, Hydrazones, Appetite, Cell Biology, Endocrinology, Glucose, Pyrimidines, P110δ

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820523a0345782a3ea5f0b2738bc7a43Test
http://europepmc.org/articles/PMC3343648Test

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