التفاصيل البيبلوغرافية
| العنوان: |
Results of mechanical circulatory support in France |
| المؤلفون: |
Mazzucotelli, Jean-Philippe1 jean-philippe.mazzucotelli@chru-strasbourg.fr, Leprince, Pascal2, Litzler, Pierre-Yves3, Vincentelli, André4, Le Guyader, Alexandre5, Kirsch, Matthias6, Camilleri, Lionel7, Flecher, Erwan8 |
| المصدر: |
European Journal of Cardio-Thoracic Surgery. Sep2011, Vol. 40 Issue 3, pe112-e117. 0p. |
| مصطلحات موضوعية: |
*CARDIOMYOPATHIES, *MEDICAL equipment, *HEART transplantation, *HEART failure, *CARDIOGENIC shock, *MORTALITY, *MEDICAL statistics |
| مصطلحات جغرافية: |
FRANCE |
| مستخلص: |
Abstract: Objective: To present the analyzed results on mechanical circulatory support (MCS) collected over a 7-year period, from 2000 to 2006, in France. Methods: A cohort of 520 patients was analyzed. Mean age was 43.7±13.6 years. The main causes of cardiac failure were ischemic cardiomyopathy (39%), idiopathic dilated cardiomyopathy (41.3%), or myocarditis (6.4%). Bridge to transplantation was indicated in 87.8% of patients, bridge to recovery in 9%, while destination therapy was proposed in 3.2% of patients. Results: For patients in cardiogenic shock or advanced heart failure undergoing device implantation as bridge to transplantation or recovery (n =458), overall mortality was 39% (n =179). The main causes of mortality under MCS were multi-organ failure (MOF) (57.4%), neurological events (14.1%), or infections (11.9%). Heart transplantation was performed in 249 (54.3%) patients. The main causes of death following heart transplantation were primary graft failure (22.4%), MOF (14.3%), neurological event (14.3%), or infection (10.2%). Long-term survival in transplanted patients was 75±2.8% at 1 year and 66±3.4% at 5 years. Conclusions: MCS is an essential therapeutic tool to save the life of young patients with cardiogenic shock or advanced cardiac failure. Early MCS implantation and the availability of a device that is adapted to the patient''s clinical status are prerequisites for reducing overall mortality rates. [Copyright &y& Elsevier] |
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